DRSC/TRiP Functional Genomics Resources

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Protein Alignment FCRL5 and DIP-epsilon

DIOPT Version :9

Sequence 1:NP_001182317.1 Gene:FCRL5 / 83416 HGNCID:18508 Length:998 Species:Homo sapiens
Sequence 2:NP_001137799.1 Gene:DIP-epsilon / 7354433 FlyBaseID:FBgn0259714 Length:467 Species:Drosophila melanogaster


Alignment Length:360 Identity:83/360 - (23%)
Similarity:130/360 - (36%) Gaps:97/360 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   335 CERGASISFSLTTENSGNYYCTADNGLGAKPSKAVS---------LSVTVPVSHPVLNLSSPEDL 390
            |...:|::.|..|.:.||    |.|..|:..:..:|         .::|||.             
  Fly    18 CLIASSVALSTDTGSEGN----AGNVGGSTLNNVISEDPEFTDVIENITVPA------------- 65

Human   391 IFEGAKVTLHCEAQR-GSLPILYQFHHEGAALERRSANSAGGVAISF----------------SL 438
               |..|.|.|..:. ||..:.:....:.|.|...:........||.                ::
  Fly    66 ---GRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHINNV 127

Human   439 TAEHSGNYYC-----TADNGFGPQRSKAVSLSVTVPVSHPVL--TLSSAEALTFEGATVTLHCEV 496
            ..|..|.|.|     ||...:|       .:.|.||   |.:  .|:|::.:..||..|||.|:.
  Fly   128 QEEDRGRYMCQINTVTAKTQYG-------FVKVVVP---PNIDDALTSSDIIVREGDNVTLRCKA 182

Human   497 QRGSPQILYQFYHED---------MPLWSSSTPS--VGRVSFSFSLTEGHSGNYYCTADNGFGPQ 550
             :|||:...::..:|         :.:....|.|  :.|:|      ..|.|.|.|.|.||..|.
  Fly   183 -KGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERIS------RLHMGAYLCIASNGVPPS 240

Human   551 RSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSA--- 612
            .|:.:.  |:|..| |::.:........:|..:.|.|........:.||....|..:..||.   
  Fly   241 VSKRIK--VSVDFS-PMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKT 302

Human   613 ------PSGGEASFNLSLTAEHS---GNYSCEANN 638
                  || .:|:..|::|...|   |||.|.|.|
  Fly   303 ETIPGHPS-YKATMRLTITNVQSSDYGNYKCVAKN 336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FCRL5NP_001182317.1 Ig1_FcgammaR_like 23..100 CDD:143229
IG_like 29..106 CDD:214653
Ig_2 105..185 CDD:290606
IG_like 110..185 CDD:214653
Ig_3 191..262 CDD:290638
Ig_2 287..373 CDD:290606 10/46 (22%)
IG_like 300..373 CDD:214653 10/46 (22%)
Ig_2 380..466 CDD:290606 17/107 (16%)
IG_like 393..466 CDD:214653 17/94 (18%)
Ig_2 473..559 CDD:290606 26/98 (27%)
IG_like 486..561 CDD:214653 24/85 (28%)
Ig_3 565..638 CDD:290638 20/84 (24%)
IG_like 577..652 CDD:214653 20/74 (27%)
Ig_3 658..731 CDD:290638
IG_like 670..745 CDD:214653
Ig_2 754..835 CDD:290606
IG_like 759..837 CDD:214653
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 879..898
ITIM motif 1 897..902
DIP-epsilonNP_001137799.1 IG_like 59..155 CDD:214653 21/118 (18%)
Ig 69..139 CDD:143165 13/69 (19%)
IG_like 165..249 CDD:214653 25/92 (27%)
IGc2 172..237 CDD:197706 20/71 (28%)
IG_like 267..348 CDD:214653 20/71 (28%)
Ig 270..339 CDD:299845 19/68 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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