DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FCRL5 and Fcrl5

DIOPT Version :9

Sequence 1:	NP_001182317.1	Gene:	FCRL5 / 83416	HGNCID:	18508	Length:	998	Species:	Homo sapiens
Sequence 2:	XP_017446788.2	Gene:	Fcrl5 / 680697	RGDID:	1589379	Length:	594	Species:	Rattus norvegicus

Alignment Length:	923	Identity:	269/923 - (29%)
Similarity:	356/923 - (38%)	Gaps:	387/923 - (41%)

- Green bases have known domain annotations that are detailed below.

Human     3 LWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEIL 67
            ||:.|||:.||:||.....:.:::|||||||.||||:|||.|.||.||.|||||||.:...:..|
  Rat    14 LWLTLLVVTPVNGQHEAVLQSVVYLQPPWTTFFQGEKVTLFCYGFGFYLPQKTKWYRKNKTQRQL 78

Human    68 RETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAKAEVTLN 132
            |.|  :.|||:|||||.|||.....|..|||||...||:||||.:|||||||||||..:.::...
  Rat    79 RST--STLEVRESGEYWCQADNFLPSMHVHLDFRQDSLVLQAPPAVFEGDSVVLRCHTREDIAAE 141

Human   133 N-TIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKE---SCCPVSSNTVKIQVQEPFTRPV 193
            : ..|||...|......::.||.||..:|||.|.|||.|.   ...|  ||||::||||...|||
  Rat   142 SLKFYKNGKALELSGPSSELHIHHANREDNGQYTCTGRKNWHLKYTP--SNTVRVQVQELLPRPV 204

Human   194 LRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFY 258
            |.|:..|||.|:||||||:.||..:||:|.|:|.|.::.|.|..|.|.|..|.|.|:|:::|.:|
  Rat   205 LMATPSQPIDGSPVTLTCQIQLPAQRSNVQLQFCFLKNLQALESGCSNSSEFHIPAIWTEESTWY 269

Human   259 WCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYH 323
            .|:|.                                         |::.:|::.
  Rat   270 QCRAE-----------------------------------------TVNSQTEKQ---------- 283

Human   324 EGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPE 388
                                                          |:::.:||
  Rat   284 ----------------------------------------------SIALKIPV----------- 291

Human   389 DLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNG 453

  Rat   292 ----------------------------------------------------------------- 291

Human   454 FGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSS 518
               ||:.|...:..:|          |..|.:||.::.|:|.|
  Rat   292 ---QRALADFQTYIMP----------ASKLVYEGQSLLLNCSV---------------------- 321

Human   519 TPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLL 583

  Rat   322 ----------------------------------------------------------------- 321

Human   584 ELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTI 648
                                                                  ||
  Rat   322 ------------------------------------------------------NG--------- 323

Human   649 SLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASF 713
                 ||                               .|:.:.:|..|:...|.:.|...||..
  Rat   324 -----VP-------------------------------GPLKFSWYKRDMLNKKANIPKSSGAEV 352

Human   714 NLS-LTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALR 777
            .:| :....:|.|.|||.|......|..|.:.:.||||:|||||.:..|.|..|||:.|||::.|
  Rat   353 KISKVNVSDAGEYYCEAKNSRRRFVSRAVPITIKVPVSQPVLTLSSGKTQALEGDLMTLHCKSQR 417

Human   778 GSPLILYRFFHEDVTLGNRSSPS---GGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITG 839
            |||.|||.|:||:|:|||.|:.|   ||||.|.|::.|.||||.|.||||||||.||.:.:.:..
  Rat   418 GSPYILYEFYHENVSLGNSSTLSGEGGGASFNFSMSTERSGNYHCTADNGLGAQNSEAIWISVAE 482

Human   840 LTANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPA 904
            :|.|||.|...|:..|||.   .|.|..|.|||.||:||.|||||.:|||||::.|||||:|:||
  Rat   483 MTNNRSAPVIAGITVGLLI---TAVGVFLSYCWFSRQAGGKPASDESRSPSDAEPQEPTYYNMPA 544

Human   905 WEELQPVYTNEEK 917
            ..||||||:|:.|
  Rat   545 CIELQPVYSNDPK 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRL5	NP_001182317.1	Ig1_FcgammaR_like	23..100	CDD:143229	44/76 (58%)
		IG_like	29..106	CDD:214653	45/76 (59%)
		Ig_2	105..185	CDD:290606	37/83 (45%)
		IG_like	110..185	CDD:214653	33/78 (42%)
		Ig_3	191..262	CDD:290638	35/70 (50%)
		Ig_2	287..373	CDD:290606	3/85 (4%)
		IG_like	300..373	CDD:214653	3/72 (4%)
		Ig_2	380..466	CDD:290606	3/85 (4%)
		IG_like	393..466	CDD:214653	3/72 (4%)
		Ig_2	473..559	CDD:290606	7/85 (8%)
		IG_like	486..561	CDD:214653	5/74 (7%)
		Ig_3	565..638	CDD:290638	0/72 (0%)
		IG_like	577..652	CDD:214653	2/74 (3%)
		Ig_3	658..731	CDD:290638	13/73 (18%)
		IG_like	670..745	CDD:214653	16/75 (21%)
		Ig_2	754..835	CDD:290606	49/83 (59%)
		IG_like	759..837	CDD:214653	46/80 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..898		12/18 (67%)
		ITIM motif 1	897..902		3/4 (75%)
Fcrl5	XP_017446788.2	Ig	34..109	CDD:416386	44/76 (58%)
		Ig strand A	35..38	CDD:409353	0/2 (0%)
		Ig strand A'	43..46	CDD:409353	2/2 (100%)
		Ig strand B	50..56	CDD:409353	3/5 (60%)
		Ig strand C	66..71	CDD:409353	4/4 (100%)
		Ig strand E	77..82	CDD:409353	3/6 (50%)
		Ig strand F	90..95	CDD:409353	3/4 (75%)
		Ig strand G	103..109	CDD:409353	3/5 (60%)
		Ig	114..196	CDD:416386	37/83 (45%)
		Ig strand A	114..117	CDD:409353	1/2 (50%)
		Ig strand B	127..134	CDD:409353	6/6 (100%)
		Ig strand C	141..147	CDD:409353	0/5 (0%)
		Ig strand C'	150..155	CDD:409353	1/4 (25%)
		Ig strand E	159..163	CDD:409353	0/3 (0%)
		Ig strand F	173..178	CDD:409353	2/4 (50%)
		Ig strand G	186..196	CDD:409353	5/11 (45%)
		Ig_2	202..284	CDD:404734	38/178 (21%)
		Ig strand A	203..207	CDD:409353	3/3 (100%)
		Ig strand A'	211..214	CDD:409353	2/2 (100%)
		Ig strand B	216..223	CDD:409353	5/6 (83%)
		Ig strand C	230..239	CDD:409353	5/8 (63%)
		Ig strand E	254..259	CDD:409353	1/4 (25%)
		IGc2	311..372	CDD:197706	22/246 (9%)
		Ig strand B	315..319	CDD:409353	1/3 (33%)
		Ig strand C	329..333	CDD:409353	0/3 (0%)
		Ig strand E	350..354	CDD:409353	1/3 (33%)
		Ig strand F	364..369	CDD:409353	2/4 (50%)
		Ig strand G	378..381	CDD:409353	1/2 (50%)
		Ig_3	392..466	CDD:404760	42/73 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83681229
Domainoid	1	1.000	96	1.000	Domainoid score	I43556
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H137404
Inparanoid	1	1.050	351	1.000	Inparanoid score	I13931
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123429at40674
OrthoFinder	1	1.000	-	-		FOG0005273
OrthoInspector	1	1.000	-	-		otm52433
orthoMCL	1	0.900	-	-		OOG6_104580
Panther	1	1.100	-	-	LDO	PTHR11481
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X79
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.400