DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FCRL5 and Dscam3

DIOPT Version :9

Sequence 1:	NP_001182317.1	Gene:	FCRL5 / 83416	HGNCID:	18508	Length:	998	Species:	Homo sapiens
Sequence 2:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster

Alignment Length:	983	Identity:	210/983 - (21%)
Similarity:	359/983 - (36%)	Gaps:	244/983 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVF---QGERVTLTCKGFRFYSPQKTKWYHR-- 60
            :||.|:...|...||...    |...|:|....:|   .|.:||.|..|   ..|....|..|
  Fly    20 LLLAVLATPLLATSGLRV----PTFLLEPAPRLLFGNDTGAQVTCTAHG---SPPPLVTWVLRDG 77

Human    61 YLGKEI--LRETPDN-------------ILEVQESGEYRCQAQ---GSPLSSPV----------H 97
            .|..::  ||:...|             ..:|.|: .|||:|.   |:.||..|          |
  Fly    78 SLATQVPGLRKISGNGTLHFPPFLAQYYRTDVHEA-TYRCRASNEAGTVLSRNVQVHAVVRRQFH 141

Human    98 LDFSSASLILQAPLSVFEGDSVVLRC------RAKAEVTLNNTIYKNDNVL-----------AFL 145
            :...:.        .|:.|:|.:::|      |....|.   :.::.:.:|           ..|
  Fly   142 VHVENT--------EVYLGNSALIKCAIPEYVRPYVRVA---SWHRGEEILLPDLSDVAGRYVVL 195

Human   146 NKRTDFHIPHACLKDNGAYRCTGYKESCCPVS---------SNTVKIQVQEPFTRPVLRASSFQP 201
            ....|.::.....:|       |..:..|.|:         |:.|.:||:| .::.:...::.:|
  Fly   196 AASGDLYVRSVRSED-------GLMKFSCLVTNTLNGERQRSDAVMLQVKE-LSKNLAPRTTQKP 252

Human   202 I------SGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQ----------ITAM 250
            :      .||.|.|.|    :::.:..|: |.::|...:..| :.: |:.|          |...
  Fly   253 VMEIHVERGNDVHLPC----NIQGNPFPI-FTWYRVSDSAAL-YPI-PSSQRVILSRTLLLIKNA 310

Human   251 WSKDSGFYWCKAATM---PYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQE 312
            ..:|:|.:.|:|:..   ....|..|..|::.|.|        |...:.:|..|| ...:|.|..
  Fly   311 DERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHI--------LPQVQIVNSGGT-ANFNCTTTG 366

Human   313 DSLRTLYRFYHEGVPLRHKSVRCERGASISF----SLTTENSGN-----YYCTADNGLGAKPSKA 368
            .::..: .:.|.|.||:..:.......:|.|    ||..:|.|.     |.|..:|...:..:.|
  Fly   367 SAIDAI-DWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMA 430

Human   369 -VSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRG----------SLPIL-YQFHHEGAAL 421
             :.|..||    |.|..:..|..:..|..::|.|.|...          |.||: ...||..|.
  Fly   431 ELKLGDTV----PELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAI- 490

Human   422 ERRSANSAGGVAISFSLT---AEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEAL 483
             .:..:.:|.|....:::   .:..|.|.|.|.|..|     :|..|..:.|..|....:.....
  Fly   491 -GQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMG-----SVQHSARLNVYGPPYVRAIGPIK 549

Human   484 TFEGATVTLHCEVQRGSP--QILYQFYHEDMPLWS----SSTPSVGRVSFSFSLTEGHSGNYYCT 542
            ...|..:.:||.. .|.|  ||.::..|:::...:    :|....|::...........|.|.|.
  Fly   550 AVAGEDIIVHCPF-AGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCI 613

Human   543 ADNGFGPQRSEVVSLFVTVPVSRPIL-TLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVT 606
            ..:..|.:....:.|.|..|   |:: ..:.|: ....|...::.|....|..||.:.:..:|
  Fly   614 VRSRAGEEARRDMQLNVNSP---PVIEPFKFPK-NLQEGGRAQITCAVSSGDMPIYFSWKKDD-- 672

Human   607 LGSSSAPSG------GEASFNL----SLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPIL 661
               ||.||.      .|..::|    .::|.|||.|:|.|:|. .|:.:.|..|.|.|
  Fly   673 ---SSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNA-AAKVNYTAELQVRV------- 726

Human   662 TFRAPR-------AQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTT 719
               |||       ...::|:.:.::|||.....|.:.||..:..........|....|..|:|.|
  Fly   727 ---APRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLAT 788

Human   720 EH-SGIYSCEADNGLEAQRSEMVTLKVAVPV-----SRPVLTLRAPGTHAAVGDLLELHCEALRG 778
            :: .|.|.|:|.|.:.|...:.:.:.|..|.     :|.:.:.|        .|.:.|.|.|...
  Fly   789 DNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRR--------NDPVTLDCHAKGD 845

Human   779 SPLIL-------------YRFFHEDVTLGNRSSPSGGASLNLSLTAEH-----SGNYSCEADNGL 825
            .|:.:             :||     ::....:..|   ::..||..|     ||.|.|.|:|..
  Fly   846 EPITIGWTQNNGRIDLNNFRF-----SIAEMKTEKG---VDSQLTIGHSDRHDSGVYRCIAENPY 902

Human   826 GAQRSETV 833
            |  |:|.:
  Fly   903 G--RAEQI 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRL5	NP_001182317.1	Ig1_FcgammaR_like	23..100	CDD:143229	27/109 (25%)
		IG_like	29..106	CDD:214653	25/109 (23%)
		Ig_2	105..185	CDD:290606	15/105 (14%)
		IG_like	110..185	CDD:214653	15/100 (15%)
		Ig_3	191..262	CDD:290638	16/86 (19%)
		Ig_2	287..373	CDD:290606	21/95 (22%)
		IG_like	300..373	CDD:214653	19/82 (23%)
		Ig_2	380..466	CDD:290606	22/99 (22%)
		IG_like	393..466	CDD:214653	19/86 (22%)
		Ig_2	473..559	CDD:290606	16/91 (18%)
		IG_like	486..561	CDD:214653	16/80 (20%)
		Ig_3	565..638	CDD:290638	21/83 (25%)
		IG_like	577..652	CDD:214653	23/84 (27%)
		Ig_3	658..731	CDD:290638	19/80 (24%)
		IG_like	670..745	CDD:214653	18/75 (24%)
		Ig_2	754..835	CDD:290606	21/98 (21%)
		IG_like	759..837	CDD:214653	20/93 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..898
		ITIM motif 1	897..902
Dscam3	NP_996226.2	IG	56..133	CDD:214652	21/80 (26%)
		Ig	56..125	CDD:143165	18/72 (25%)
		I-set	246..337	CDD:254352	18/97 (19%)
		Ig	264..334	CDD:143165	14/76 (18%)
		I-set	345..433	CDD:254352	21/97 (22%)
		Ig	358..431	CDD:143165	15/73 (21%)
		Ig	456..533	CDD:143165	19/83 (23%)
		IGc2	553..619	CDD:197706	13/66 (20%)
		I-set	634..724	CDD:254352	25/96 (26%)
		ig	645..712	CDD:278476	19/71 (27%)
		IG_like	734..815	CDD:214653	18/80 (23%)
		Ig	745..815	CDD:299845	17/69 (25%)
		I-set	820..913	CDD:254352	22/107 (21%)
		Ig	838..920	CDD:299845	19/81 (23%)
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910