DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FCRL5 and dpr17

DIOPT Version :9

Sequence 1:	NP_001182317.1	Gene:	FCRL5 / 83416	HGNCID:	18508	Length:	998	Species:	Homo sapiens
Sequence 2:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster

Alignment Length:	790	Identity:	142/790 - (17%)
Similarity:	237/790 - (30%)	Gaps:	304/790 - (38%)

- Green bases have known domain annotations that are detailed below.

Human   206 PVTLTCETQLS--LERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKA--ATMP 266
            |.|||.|..::  .||:.|                                 |..||:.  .|.|
  Fly    61 PATLTTEMTVAGRAERAGV---------------------------------GAPWCRRFFHTSP 92

Human   267 YSVISDSPRSWIQVQ-----IPA----------SHPVLTLSPEKAL-------NFEGTKVTLHCE 309
            .:       ||:::.     :||          |:|.|..|....:       |.||...|....
  Fly    93 LA-------SWLRISFVLLVLPALGFGIQVVTCSNPELGASAPDPVDLTWGGKNTEGQLTTATRS 150

Human   310 TQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADN-GLGAKPSKAVSLSV 373
            |..||                             .:||:|  :...||.| ....||:.|.|.:|
  Fly   151 TLPDS-----------------------------PMTTQN--DLITTASNLATAKKPATAASEAV 184

Human   374 --------TVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAG 430
                    |.|.:....:.||                                .|:.|..:::.|
  Fly   185 VDTAETAETAPPTEATSSWSS--------------------------------TAVARGMSSADG 217

Human   431 -GVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHC 494
             |.||:.|.:|:.......|.      ::::|.:.|.....:......:||...:...||.|
  Fly   218 AGEAIATSQSAQIGLTTQATV------RQTEAQTASTATQAAAATSAATSAAIASAAAATET--- 273

Human   495 EVQRGSPQILYQFYHEDMPLWSSSTP-----SVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEV 554
                 :.::|..      .::.:||.     |:.||       ||..|.    ..|.|.|...:.
  Fly   274 -----AAEMLIS------TIYPASTETDLHNSIERV-------EGQRGK----MANAFHPGVPDS 316

Human   555 VSLFVTVPVSRP------ILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAP 613
            ::...::|...|      ...|...||.|...:..:|..||                ...:::|.
  Fly   317 LTKGFSIPTFLPPFPVFAAADLPAYRAAADAAEAAKLAAEA----------------AAQAAAAK 365

Human   614 SGGEASFNLSLTAEHSGNYSCEANNGLVAQH---SDTISLSVIVPVSRPILTFRAPRAQAVVGDL 675
            :..||   ::::.|..........:..:|.|   .|....:|...::.|:|...|.     :|:.
  Fly   366 TSSEA---VTMSPEEQRRQMFNEQHSYLAAHRDGGDGAGSAVRRNLTMPVLNITAQ-----MGNH 422

Human   676 LELHCEALRGSSPILYW------------------------FYHEDVTLGKISAPSGGGASFNLS 716
            ..:.|:..|.|...:.|                        .|.||             ..:..|
  Fly   423 AYMPCQIHRLSDKPVSWVRMRDNHIISVDETTFIADERFQSIYQED-------------HDYTWS 474

Human   717 LTTEH-----SGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEAL 776
            |..::     :|.|.|:.  ..|.:.|..|.|::..|.:.   .:.........|..:.||| .:
  Fly   475 LQIKYVEPSDAGWYECQM--ATEPKLSAKVHLQIVKPKTE---LIGDQSRFVKAGSKVALHC-IV 533

Human   777 RGS---PLIL------------------YRFFHEDV--TLGNRSSPSGGASLNLSLTAEHSGNYS 818
            ||:   |..:                  |.....::  |:|:..:..|...:.| :..|.||||:
  Fly   534 RGTLDPPKYIIWFRGQKKISDSDERTGWYTQLDRNIFGTVGDNQNTIGSLIIPL-VRKEDSGNYT 597

Human   819 CEADNGLGAQRSETVTLYI------------TGLTANRSGPFATGVAGGLLSIAGLAAGALLLYC 871
            |:..|.:    |.:|.|::            |.....:.|........|||.|.||        .
  Fly   598 CQPSNSV----SVSVDLHVLSGEYSASAIMSTAARTTKGGRSTCHSTLGLLGILGL--------L 650

Human   872 WLSRKAGRKP 881
            |..:.|...|
  Fly   651 WAMQGAMHTP 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRL5	NP_001182317.1	Ig1_FcgammaR_like	23..100	CDD:143229
		IG_like	29..106	CDD:214653
		Ig_2	105..185	CDD:290606
		IG_like	110..185	CDD:214653
		Ig_3	191..262	CDD:290638	11/57 (19%)
		Ig_2	287..373	CDD:290606	20/93 (22%)
		IG_like	300..373	CDD:214653	16/73 (22%)
		Ig_2	380..466	CDD:290606	12/86 (14%)
		IG_like	393..466	CDD:214653	10/73 (14%)
		Ig_2	473..559	CDD:290606	17/90 (19%)
		IG_like	486..561	CDD:214653	15/79 (19%)
		Ig_3	565..638	CDD:290638	12/78 (15%)
		IG_like	577..652	CDD:214653	11/77 (14%)
		Ig_3	658..731	CDD:290638	16/101 (16%)
		IG_like	670..745	CDD:214653	17/103 (17%)
		Ig_2	754..835	CDD:290606	21/103 (20%)
		IG_like	759..837	CDD:214653	22/100 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..898		1/3 (33%)
		ITIM motif 1	897..902
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	13/94 (14%)
		Ig	415..507	CDD:299845	18/111 (16%)
		IG_like	521..612	CDD:214653	22/96 (23%)
		IGc2	524..605	CDD:197706	19/86 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910