DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FCRL5 and Dscam2

DIOPT Version :9

Sequence 1:	NP_001182317.1	Gene:	FCRL5 / 83416	HGNCID:	18508	Length:	998	Species:	Homo sapiens
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	1014	Identity:	233/1014 - (22%)
Similarity:	383/1014 - (37%)	Gaps:	230/1014 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    63 GKEILRETPDNILEVQESGEY-RCQAQGSPLSSP--VHLDFSSASLILQAPLSVFEGDSVVLRCR 124
            |...:.|.|..:.....||.: .|.|.|||..:.  ||.|.|:.:.|......:..|..|::...
  Fly    30 GPGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDWVHADGSAVTEIHGVRRVLRNGTLVLMPFA 94

Human   125 AKA-EVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEP 188
            |.| ...::||||:                   |:..|...|..........|.:...|:.|:
  Fly    95 AAAYHQDVHNTIYR-------------------CIASNSVGRIVSRDVQVRAVVAQAYKVDVE-- 138

Human   189 FTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSK 253
                ||.|:     .|....|.|.         ||.    |..:....:.|...|...|......
  Fly   139 ----VLSAA-----RGCTAILRCV---------VPT----FVKELVRVVSWVHEPAIYIYPSLQG 181

Human   254 DSGFYWCKAATMPYSVISDSPRSW---------IQVQIPASHPV-LTLSPEKA-LNFEGTKVTLH 307
            |..|:......:....:.:|..|.         :..|:..|.|. |.::..:. ::....:.|.|
  Fly   182 DGKFHLLPTGELLIHNLQESDESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAH 246

Human   308 CETQEDSLRTL-----------YR-FYHEGV-PLRHKS---VRCERGASISFSLTTENSGNYYCT 356
            .:..:|....|           |. |.|.|. ||...|   ||.........::|.|:||.|.||
  Fly   247 VQVSQDEGAVLLCVAQGCPSPEYSWFTHNGAGPLPVLSGPRVRLLGPILAIEAVTGEDSGVYKCT 311

Human   357 ADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDL-IFEGAKVTLHCEAQRGSLPILYQ---FHHE 417
            |.| :|.:.|..:.|:|..|:...:    ||..| :..|......|.......|:..|   ::.:
  Fly   312 AGN-VGGEASAELRLTVATPIQVEI----SPNVLSVHMGGTAEFRCLVTSNGSPVGMQNILWYKD 371

Human   418 GAALERRSANSAGGVAISF---SLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPV----SHPVL 475
            |     |...|:|.|..:.   .::.|:.|.|.|..      :|.:..:...|..:    :.|||
  Fly   372 G-----RQLPSSGRVEDTLVVPRVSRENRGMYQCVV------RRPEGDTFQATAELQLGDAPPVL 425

Human   476 TLSSAEALTFEGATVTLHCEVQ-RGSPQILYQFYHEDMPLWSSSTPSVGR-----------VSFS 528
            ..|..|.....|..|:|.|... ..:|||.:..  :..||.|:....:|:           |:.|
  Fly   426 LYSFIEQTLQPGPAVSLKCSAAGNPTPQISWTL--DGFPLPSNGRFMIGQYITVHGDVISHVNIS 488

Human   529 FSLTEGHSGNYYCTADNGFG-PQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRG 592
            ..:.| ..|.|.|.|:|..| .|.:..::::     ..|.:.| :|:..||.|:.|.|.|  |..
  Fly   489 HVMVE-DGGEYACIAENRAGRVQHAARLNIY-----GLPYIRL-IPKVTAVSGETLNLKC--PVA 544

Human   593 SPPI--LYWFYHEDVTLGSSSAPSG------GEASFNLSLTAEH--SGNYSCEANN--GLVAQHS 645
            ..||  ::|      ..|....|..      .:.|..:|...::  ||.|:|.|.|  |..|:.|
  Fly   545 GYPIEEIHW------ERGGRELPDDIRQRVQPDGSLTISPVQKNSDSGVYTCWARNKQGHSARRS 603

Human   646 DTISLSVIVPVSRPILT-FRAPRAQAVVGDLLELHCEALRGSSPI-LYWFYHEDVTLGKISAPSG 708
            ..:  :||||   |.|: |:....|..:||...|.|..::|..|: :.|  .:|   |:...|:.
  Fly   604 GEV--TVIVP---PKLSPFQTNILQLNMGDRASLTCSVVKGDLPLTINW--RKD---GRPIDPTQ 658

Human   709 GGA-----SFNL-----SLTTEHSGIYSCEADN-GLEAQRSEMVTLKVAVP---VSRPVLTLRAP 759
            ..:     .:|.     :|.::|:|.|||...| ..|.:.|:  .|.|.||   :..||......
  Fly   659 HMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQ--ALLVNVPPRWIVEPVDANVER 721

Human   760 GTHAAVGDLLELHCEALRG--SPLILYRFF-------HEDV-------TLGNRSSPSGGASLNLS 808
            ..|      :.|||:| :|  :|.|:::..       :|:|       .|||      |:.|...
  Fly   722 NRH------IMLHCQA-QGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGN------GSLLLQH 773

Human   809 LTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIAGLAAGALLLYCWL 873
            :..:..|.|.|:|:||:|....:.:.|.:      .|.|:.:..:..::...|..|   ||.|.:
  Fly   774 VKEDREGFYLCQANNGIGTGIGKVIQLKV------NSSPYFSSTSRSVMVKKGDTA---LLQCAV 829

Human   874 SRKAGRKPAS-----------DPARSPSDSDSQEPTYHNVPAWEELQPVYTNEEKMWF---TQKY 924
            |   |.||.:           :|:.:...|..||.|...|.|..:::.|...:...:|   :..|
  Fly   830 S---GDKPINIVWMRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLY 891

Human   925 GSSKRKRNMQW---PLTPGISGTRVPLSSTLKLRWRQPR 960
            |:.::...:|.   ||.|.:....:..|.::.::| ||:
  Fly   892 GNDQQLVQLQVQEPPLPPSVLEAAMISSRSVNIKW-QPK 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRL5	NP_001182317.1	Ig1_FcgammaR_like	23..100	CDD:143229	12/39 (31%)
		IG_like	29..106	CDD:214653	14/45 (31%)
		Ig_2	105..185	CDD:290606	14/80 (18%)
		IG_like	110..185	CDD:214653	13/75 (17%)
		Ig_3	191..262	CDD:290638	14/70 (20%)
		Ig_2	287..373	CDD:290606	27/103 (26%)
		IG_like	300..373	CDD:214653	25/88 (28%)
		Ig_2	380..466	CDD:290606	17/92 (18%)
		IG_like	393..466	CDD:214653	14/78 (18%)
		Ig_2	473..559	CDD:290606	26/98 (27%)
		IG_like	486..561	CDD:214653	21/87 (24%)
		Ig_3	565..638	CDD:290638	22/82 (27%)
		IG_like	577..652	CDD:214653	23/86 (27%)
		Ig_3	658..731	CDD:290638	21/84 (25%)
		IG_like	670..745	CDD:214653	21/86 (24%)
		Ig_2	754..835	CDD:290606	22/96 (23%)
		IG_like	759..837	CDD:214653	23/93 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..898		6/29 (21%)
		ITIM motif 1	897..902		1/4 (25%)
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845	21/94 (22%)
		Ig	138..>203	CDD:299845	15/88 (17%)
		I-set	238..327	CDD:254352	25/89 (28%)
		Ig	247..327	CDD:299845	23/80 (29%)
		I-set	332..418	CDD:254352	18/100 (18%)
		IGc2	344..407	CDD:197706	14/73 (19%)
		IG_like	432..517	CDD:214653	21/87 (24%)
		IGc2	436..507	CDD:197706	19/73 (26%)
		I-set	521..610	CDD:254352	27/99 (27%)
		IGc2	533..597	CDD:197706	18/71 (25%)
		Ig	630..699	CDD:143165	17/73 (23%)
		IG_like	714..802	CDD:214653	25/100 (25%)
		Ig	725..802	CDD:299845	22/83 (27%)
		Ig	823..894	CDD:143165	19/76 (25%)
		FN3	906..1006	CDD:238020	7/25 (28%)
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910