DRSC/TRiP Functional Genomics Resources

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Protein Alignment FCRL5 and Lac

DIOPT Version :9

Sequence 1:NP_001182317.1 Gene:FCRL5 / 83416 HGNCID:18508 Length:998 Species:Homo sapiens
Sequence 2:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster


Alignment Length:308 Identity:79/308 - (25%)
Similarity:124/308 - (40%) Gaps:52/308 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   280 VQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLR-----TLYRFYHEGVPLRHKSVRCERGA 339
            ||....:.||.|..:....|..|..||..:....|||     :.|:       |:.|.::     
  Fly    52 VQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDPNSSTYK-------LQIKDIQ----- 104

Human   340 SISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLI-FEGAKVTLHCEA 403
                   ..::|.|.|........|.|..|.|||..|   ||::.:|.:.:: .||::|.:.|.|
  Fly   105 -------ETDAGTYTCQVVISTVHKVSAEVKLSVRRP---PVISDNSTQSVVASEGSEVQMECYA 159

Human   404 QRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTV 468
            .....|.:.......|.|...||...|......|:..|..|.|||.||||.    ||....::.|
  Fly   160 SGYPTPTITWRRENNAILPTDSATYVGNTLRIKSVKKEDRGTYYCVADNGV----SKGDRRNINV 220

Human   469 PVSH-PVLTLSS---AEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSF 529
            .|.. ||:|:..   .:||.::   :.|.|.::...|..:. :..:|:.|.::...|:...:.:.
  Fly   221 EVEFAPVITVPRPRLGQALQYD---MDLECHIEAYPPPAIV-WTKDDIQLANNQHYSISHFATAD 281

Human   530 SLTEG----------HSGNYYCTADNGFGPQRSEVVSLFVT-VPVSRP 566
            ..|:.          ..|:|.|.|.|.||...:. |:||.| :||..|
  Fly   282 EYTDSTLRVITVEKRQYGDYVCKATNRFGEAEAR-VNLFETIIPVCPP 328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FCRL5NP_001182317.1 Ig1_FcgammaR_like 23..100 CDD:143229
IG_like 29..106 CDD:214653
Ig_2 105..185 CDD:290606
IG_like 110..185 CDD:214653
Ig_3 191..262 CDD:290638
Ig_2 287..373 CDD:290606 20/90 (22%)
IG_like 300..373 CDD:214653 16/77 (21%)
Ig_2 380..466 CDD:290606 26/86 (30%)
IG_like 393..466 CDD:214653 23/72 (32%)
Ig_2 473..559 CDD:290606 21/98 (21%)
IG_like 486..561 CDD:214653 18/85 (21%)
Ig_3 565..638 CDD:290638 1/2 (50%)
IG_like 577..652 CDD:214653
Ig_3 658..731 CDD:290638
IG_like 670..745 CDD:214653
Ig_2 754..835 CDD:290606
IG_like 759..837 CDD:214653
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 879..898
ITIM motif 1 897..902
LacNP_523713.2 IG_like 36..131 CDD:214653 22/97 (23%)
FR1 37..50 CDD:409353
Ig strand A' 37..42 CDD:409353
Ig strand B 44..51 CDD:409353
CDR1 51..59 CDD:409353 2/6 (33%)
Ig strand C 59..63 CDD:409353 2/3 (67%)
FR2 60..63 CDD:409353 2/2 (100%)
CDR2 67..81 CDD:409353 4/13 (31%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 9/49 (18%)
Ig strand D 84..90 CDD:409353 3/5 (60%)
Ig strand E 94..102 CDD:409353 2/14 (14%)
Ig strand F 108..115 CDD:409353 3/6 (50%)
CDR3 116..124 CDD:409353 1/7 (14%)
FR4 124..130 CDD:409353 2/5 (40%)
Ig strand G 124..130 CDD:409353 2/5 (40%)
Ig_3 134..208 CDD:404760 22/76 (29%)
Ig strand B 153..157 CDD:409353 1/3 (33%)
Ig strand C 166..170 CDD:409353 0/3 (0%)
Ig strand E 187..191 CDD:409353 0/3 (0%)
Ig strand F 201..206 CDD:409353 3/4 (75%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 19/95 (20%)
Ig strand C 256..260 CDD:409353 0/4 (0%)
Ig strand E 286..290 CDD:409353 0/3 (0%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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