DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FCRL5 and Fcrl5

DIOPT Version :9

Sequence 1:	NP_001182317.1	Gene:	FCRL5 / 83416	HGNCID:	18508	Length:	998	Species:	Homo sapiens
Sequence 2:	NP_899045.3	Gene:	Fcrl5 / 329693	MGIID:	3053558	Length:	596	Species:	Mus musculus

Alignment Length:	944	Identity:	277/944 - (29%)
Similarity:	368/944 - (38%)	Gaps:	393/944 - (41%)

- Green bases have known domain annotations that are detailed below.

Human     3 LWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEIL 67
            :|:.|||:.||:||.....:.::.|||||||.|:||.|||||..|.|..|||||||.:   ::.:
Mouse    14 MWLTLLVVTPVNGQHEAAQQSVVSLQPPWTTFFRGEVVTLTCYRFGFSVPQKTKWYQK---RKTV 75

Human    68 RETPD------NILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAK 126
            ::||.      :.|:|.|||||.|||.....|..|:::||...|:||||.:|||||||||||.||
Mouse    76 KQTPGALVIKAHTLKVHESGEYWCQADSLLPSMHVNVEFSEDFLVLQAPPAVFEGDSVVLRCYAK 140

Human   127 AEVTLNN-TIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESC--CPVSSNTVKIQVQEP 188
            ..:.... |.||:...|....:.::|:|..|.|||||.|:||..|:..  ...:||||.:||||.
Mouse   141 KGIEAETLTFYKDGKALTLHPQSSEFYIHRANLKDNGQYKCTSKKKWSFGSLYTSNTVVVQVQEL 205

Human   189 FTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSK 253
            |.||||||....||.|:||||||:||||.::||..|:|.|||:.|.||.|.|.|..|.|.|:|::
Mouse   206 FPRPVLRARPSHPIDGSPVTLTCQTQLSAQKSDARLQFCFFRNLQLLGSGCSRSSEFHIPAIWTE 270

Human   254 DSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTL 318
            :|..|.|||.|: .|.:|....::|
Mouse   271 ESKRYQCKAETV-NSQVSKQSTAFI---------------------------------------- 294

Human   319 YRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLN 383
                   :|::..|.|
Mouse   295 -------IPVQRASAR------------------------------------------------- 303

Human   384 LSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYC 448
                                        :|.|
Mouse   304 ----------------------------FQTH--------------------------------- 307

Human   449 TADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMP 513
                              .:|          |..|.|||..:.|:|.|
Mouse   308 ------------------IIP----------ASKLVFEGQLLLLNCSV----------------- 327

Human   514 LWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAV 578

Mouse   328 ----------------------------------------------------------------- 327

Human   579 VGDLLELHCEAPRGSP-PILYWFYHEDVTLGSSSAPSGGEASFNLS-LTAEHSGNYSCEANNGLV 641
                        :|.| |:.:.:|.:|:....:.......|.|.:| :....:|.|.|||||
Mouse   328 ------------KGVPGPLKFSWYKKDMLNKETKILKSSNAEFKISQVNISDAGEYYCEANN--- 377

Human   642 AQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAP 706
                           ||
Mouse   378 ---------------SR------------------------------------------------ 379

Human   707 SGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLEL 771
                .||                     ..|:..:|:|  ||||:|||||....|.|..|||:.|
Mouse   380 ----RSF---------------------VSRAFPITIK--VPVSQPVLTLSTGKTQALEGDLMTL 417

Human   772 HCEALRGSPLILYRFFHEDVTLGNRSSPS-GGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTL 835
            ||::.||||.|||.||:|:|:|||.|..| |||..|.|::.|.||||.|.||||||||.||.:.:
Mouse   418 HCQSQRGSPCILYEFFYENVSLGNSSILSGGGAYFNFSMSTERSGNYYCTADNGLGAQCSEAIRI 482

Human   836 YITGLTANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYH 900
            .|..:|.|||.|.|.|:..|||.   :|.|..|.|||.|||||.||.||.:|:||||:.|||||:
Mouse   483 SIFDMTKNRSVPMAAGITVGLLI---MAVGVFLFYCWFSRKAGGKPTSDDSRNPSDSEPQEPTYY 544

Human   901 NVPAWEELQPVYTN--EEKMWFTQKYGSSKRKRN 932
            ||||..||||||:|  ||.:.:|:...:..|:::
Mouse   545 NVPACIELQPVYSNEPEENVIYTEVRRTQPRQKH 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRL5	NP_001182317.1	Ig1_FcgammaR_like	23..100	CDD:143229	38/82 (46%)
		IG_like	29..106	CDD:214653	38/82 (46%)
		Ig_2	105..185	CDD:290606	38/82 (46%)
		IG_like	110..185	CDD:214653	34/77 (44%)
		Ig_3	191..262	CDD:290638	39/70 (56%)
		Ig_2	287..373	CDD:290606	3/85 (4%)
		IG_like	300..373	CDD:214653	3/72 (4%)
		Ig_2	380..466	CDD:290606	2/85 (2%)
		IG_like	393..466	CDD:214653	2/72 (3%)
		Ig_2	473..559	CDD:290606	8/85 (9%)
		IG_like	486..561	CDD:214653	5/74 (7%)
		Ig_3	565..638	CDD:290638	13/74 (18%)
		IG_like	577..652	CDD:214653	15/76 (20%)
		Ig_3	658..731	CDD:290638	3/72 (4%)
		IG_like	670..745	CDD:214653	4/74 (5%)
		Ig_2	754..835	CDD:290606	48/81 (59%)
		IG_like	759..837	CDD:214653	45/78 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..898		11/18 (61%)
		ITIM motif 1	897..902		3/4 (75%)
Fcrl5	NP_899045.3	Ig	34..112	CDD:299845	38/80 (48%)
		IG_like	40..101	CDD:214653	32/63 (51%)
		Ig	119..202	CDD:299845	38/82 (46%)
		IG_like	127..200	CDD:214653	33/72 (46%)
		Ig_2	209..297	CDD:290606	44/135 (33%)
		Ig_2	308..391	CDD:290606	29/277 (10%)
		IG_like	310..393	CDD:214653	31/279 (11%)
		Ig_2	398..484	CDD:290606	50/85 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..544		14/21 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..596		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83955692
Domainoid	1	1.000	112	1.000	Domainoid score	I42517
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H137404
Inparanoid	1	1.050	369	1.000	Inparanoid score	I14126
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208751at32523
OrthoFinder	1	1.000	-	-		FOG0005273
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104580
Panther	1	1.100	-	-	LDO	PTHR11481
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R12642
SonicParanoid	1	1.000	-	-		X79
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.430