DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FCRL5 and LOC108648322

DIOPT Version :9

Sequence 1:	NP_001182317.1	Gene:	FCRL5 / 83416	HGNCID:	18508	Length:	998	Species:	Homo sapiens
Sequence 2:	XP_017952078.1	Gene:	LOC108648322 / 108648322	-ID:	-	Length:	623	Species:	Xenopus tropicalis

Alignment Length:	617	Identity:	144/617 - (23%)
Similarity:	241/617 - (39%)	Gaps:	116/617 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     3 LWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTC------KGFRFYSPQKTKWYHRY 61
            |.|:|.:.|..:|...|.   .:...|.|.:.|..|.|||||      :|...|.     ||
Frog     6 LLVLLFMAAENAGAAGRA---TVSFSPNWASAFTSESVTLTCNVSSSAQGEPPYF-----WY--- 59

Human    62 LGKEILR-ETPDNILEV-----QESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVV 120
              |:.:| ||......:     .:||.|:|::..|..|..|.|..|...|.|:.|..|||||::.
Frog    60 --KDGVRMETKQQKYTIFNAKKSDSGVYQCKSHSSDRSDSVTLTISDDYLSLKVPPFVFEGDNLQ 122

Human   121 LRCRAKAEVTLNNTIYKNDNVLAFLNKRT---------DFHIPHACLKDNGAYRC--------TG 168
            :.|.....       ||.|.  |.|||..         :|:.....:..:|:|.|        ..
Frog   123 VSCAGYPG-------YKADT--AKLNKGNQLIGSSPSGNFNFGRVTMATSGSYICYRAVKHHLIY 178

Human   169 YKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQ 233
            |.:      .::|.|.|:|.|:.|.::.|:.|...|:.:|:||:|:||..|....|:|.|:|:..
Frog   179 YNQ------KSSVYISVKELFSSPQIKVSTDQVTEGDRMTITCDTELSPHRETTELQFAFYRNGH 237

Human   234 TLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPV-LTLSPEKAL 297
            .: .|:|||..:.:::...:|||:|.|:.......|...|.|..||::......| :.|.|....
Frog   238 NV-QGFSLSNQYGVSSAQLEDSGYYTCEIRAQSGIVNKKSDRKSIQIRTKKLAGVRVRLEPAGGQ 301

Human   298 NFEGTKVTLHCETQEDSLRTLYRFYHEGVPL-RHKSVRCERGASISFSLTTENSGNYYCTADNGL 361
            ...|.|:.:.|..::......|.:..:...: ..|.........::.|::.:..|.|.|......
Frog   302 VIAGEKLEILCSVEKGMGLLRYSWCKQPTLICNTKEAAAPEQRFVAESVSEDYGGEYQCIITRTA 366

Human   362 GAKPSKAVSLSVTV--PVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFH------HEG 418
            ..:..::.::|::|  ||:...:.....|..:.....:.|.|...:|:.|:....|      ||.
Frog   367 TGESIRSANISISVQEPVADARITPEEDELAVKVEDNLCLTCSVAKGTNPLFLWIHNNKTIGHES 431

Human   419 AALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQR-----SKAVSLSVT----------V 468
            ...:.|   .:|.|....|...:|:|.|:|...|.....|     |..|::|::          :
Frog   432 VLYQVR---ESGKVLCIESAQLQHAGTYWCEVRNQLSSNRIFTVTSNIVTISISGNTYRYVVMGI 493

Human   469 PVSHPVLTLSSAEAL-----------------TFEGATVTLHCEVQRGSP--QILYQFY--HEDM 512
            .:|...|.|.:|..:                 |..|.:||   :.|.||.  |.:...|  ::..
Frog   494 GISLASLLLVTAIVVFKYRSTMASCFTCCHFPTSSGGSVT---KDQNGSDPRQQVANLYIPNDGK 555

Human   513 PLWSSSTPSVGRVSFSFSLTEGHSGNYYCTAD 544
            |  ....|..|.:    .:.:|....||...|
Frog   556 P--EEEQPEYGNI----VIQDGEDECYYMNYD 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRL5	NP_001182317.1	Ig1_FcgammaR_like	23..100	CDD:143229	25/88 (28%)
		IG_like	29..106	CDD:214653	26/88 (30%)
		Ig_2	105..185	CDD:290606	23/96 (24%)
		IG_like	110..185	CDD:214653	21/91 (23%)
		Ig_3	191..262	CDD:290638	24/70 (34%)
		Ig_2	287..373	CDD:290606	12/87 (14%)
		IG_like	300..373	CDD:214653	9/73 (12%)
		Ig_2	380..466	CDD:290606	20/96 (21%)
		IG_like	393..466	CDD:214653	19/83 (23%)
		Ig_2	473..559	CDD:290606	19/93 (20%)
		IG_like	486..561	CDD:214653	15/63 (24%)
		Ig_3	565..638	CDD:290638
		IG_like	577..652	CDD:214653
		Ig_3	658..731	CDD:290638
		IG_like	670..745	CDD:214653
		Ig_2	754..835	CDD:290606
		IG_like	759..837	CDD:214653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..898
		ITIM motif 1	897..902
LOC108648322	XP_017952078.1	Ig	23..102	CDD:386229	25/91 (27%)
		Ig	200..283	CDD:386229	27/83 (33%)
		Ig_3	398..462	CDD:372822	15/66 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I36893
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I11299
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208751at32523
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm10435
Panther	1	1.100	-	-	O	PTHR11481
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X79
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070