DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASP1 and Drice

DIOPT Version :9

Sequence 1:	NP_001244047.1	Gene:	CASP1 / 834	HGNCID:	1499	Length:	404	Species:	Homo sapiens
Sequence 2:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster

Alignment Length:	348	Identity:	93/348 - (26%)
Similarity:	142/348 - (40%)	Gaps:	69/348 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    88 GLSADQTS---GNYLNMQDSQGVLSSFPAPQA----VQDNPAMPTSSGSEG-------------- 131
            |.||||..   ||.....|....|.|..:..|    :....:.|..||:.|
  Fly     7 GESADQVGIRVGNPEQPNDHTDALGSVGSGGAGSSGLVAGSSHPYGSGAIGQLANGYSSPSSSYR 71

Human   132 -NVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFD--SIPRRTGAEVDITGMTMLL 193
             ||       |:.:..:.:|| |.:..|:  ..:|||..:|.|:  ::..|.|..||...:|.:|
  Fly    72 KNV-------AKMVTDRHAAE-YNMRHKN--RGMALIFNHEHFEVPTLKSRAGTNVDCENLTRVL 126

Human   194 QNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQL 258
            :.|.:.|.|.|:....|:...:| :|....|..||...:..:||| ..|....|.::     .:|
  Fly   127 KQLDFEVTVYKDCRYKDILRTIE-YAASQNHSDSDCILVAILSHG-EMGYIYAKDTQ-----YKL 184

Human   259 NAIFNMLNTKNCPSLKDKPKVIIIQACRGD--SPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKA 321
            :.|::.....:||||..|||:..||||:||  ..||...:......|:.|:.          .|.
  Fly   185 DNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGGVTMQRSQTETDGDSSMS----------YKI 239

Human   322 HIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFEQ--P 380
            .:..||:...|:.|...|||:.|.||.|:..|...:.......|:..:.    ::|...||.  |
  Fly   240 PVHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKRLDILTLLTFVCQRVAVDFESCTP 304

Human   381 D-----GRAQMP--TTERVTLTR 396
            |     .:.|:|  ||   .|||
  Fly   305 DTPEMHQQKQIPCITT---MLTR 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASP1	NP_001244047.1	CARD_CASP1-like	5..87	CDD:260036
CASP1	NP_001244047.1	CASc	153..402	CDD:214521	73/261 (28%)
Drice	NP_524551.2	CASc	86..330	CDD:214521	73/261 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910