DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASP1 and Strica

DIOPT Version :9

Sequence 1:	NP_001244047.1	Gene:	CASP1 / 834	HGNCID:	1499	Length:	404	Species:	Homo sapiens
Sequence 2:	NP_001260718.1	Gene:	Strica / 35528	FlyBaseID:	FBgn0033051	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	317	Identity:	74/317 - (23%)
Similarity:	128/317 - (40%)	Gaps:	56/317 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    89 LSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIY 153
            ||:..|...::::..|.|......|....||  |..|.|.|.| :...||.:.    |.|.|.:|
  Fly   259 LSSTATPKPFISLGSSGGTKPKVTAVAQSQD--AQGTISTSLG-ISKSSLTKN----KLKPARVY 316

Human   154 PIMDKSSRTRLALIICNEEFDSIPR-RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTT--EL 215
                         |..:|.||:... |.|:..|:..:....:.|...|:|   :|.:.:.|  :.
  Fly   317 -------------IFNHERFDNKNEFRKGSAQDVKVLRATFEQLKCKVEV---ITDATLVTIKKT 365

Human   216 EAFAHRPEHKTSDSTFLVFMSHGIR-EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKV 279
            .......:.:...:..||.:|||.| :.|..|.....:.|    :.:|.:|..:   :||||||:
  Fly   366 VRMLQTKDFEDKSALVLVILSHGTRHDQIAAKDDDYSLDD----DVVFPILRNR---TLKDKPKL 423

Human   280 IIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPT 344
            |.:|||:||.....:..|:...:|:         .::.:|.....:.|::|  .|.|
  Fly   424 IFVQACKGDCQLGGFMTDAAQPNGS---------PNEILKCYSTYEGFVSF--RTED-------- 469

Human   345 MGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLF 401
             |:.||..|.|.:.....:.|::.|...||...:......|:|:......::  |:|
  Fly   470 -GTPFIQTLCEALNRSGKTSDIDTIMMNVRQVVKMQSKDRQIPSVTSTLTSK--YVF 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASP1	NP_001244047.1	CARD_CASP1-like	5..87	CDD:260036
CASP1	NP_001244047.1	CASc	153..402	CDD:214521	56/253 (22%)
Strica	NP_001260718.1	CASc	311..523	CDD:294037	57/256 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810