DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASP1 and csp-2

DIOPT Version :9

Sequence 1:	NP_001244047.1	Gene:	CASP1 / 834	HGNCID:	1499	Length:	404	Species:	Homo sapiens
Sequence 2:	NP_001370851.1	Gene:	csp-2 / 177391	WormBaseID:	WBGene00000820	Length:	826	Species:	Caenorhabditis elegans

Alignment Length:	325	Identity:	83/325 - (25%)
Similarity:	135/325 - (41%)	Gaps:	61/325 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    94 TSGNYLNMQDSQGV--LSSFPAPQA-VQDNPAMP---TSS------------GSEGNVKLCSLEE 140
            ||.:.|....:...  .|..||||| ...:||.|   |||            |..|:....|.||
Worm   497 TSSSSLTQDPASNATGFSDVPAPQAPPTPSPADPGPTTSSSSLTQDPASNATGFSGSSPPNSFEE 561

Human   141 AQRIWKQKS-------AEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGY 198
            .:.:.:..|       ...|. .::||:.| |:||.|..|..:.:|.|::.|...::.|.:.|||
Worm   562 TRMMCEDASDGKKIDETRKYR-NNRSSKCR-AIIINNVVFCGMEKRIGSDKDKKKLSKLFERLGY 624

Human   199 SVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSH---GIREGICGKKHSEQVPDILQLNA 260
            ......||.:|::   ||......:....||..:..|||   |:..|:.|      ||  :|:..
Worm   625 QSTSYDNLKSSEI---LETVRQFTQSNHGDSLIITIMSHGDQGLLYGVDG------VP--VQMLD 678

Human   261 IFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLS-----LPTTEEFEDDAI-- 318
            |.:::.|   .||..|||.::...||||.     ...:|...|.:.     .|...:|.....
Worm   679 IIDLMCT---ASLAKKPKWLMCVCCRGDR-----IDRAVRCDGFIDNFFDRFPKFFQFMKSKFPS 735

Human   319 -KKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRL----IEHMQEYACSCDVEEIFRKVRFSFE 378
             :.:..:.|.:...|::|..:|:|..|.|:.:|..|    ||:.::...:..:.|..|:|...:|
Worm   736 HQTSSSQADLLVSFSTSPGFLSFRDETKGTWYIQELYRVIIENAKDTHLADLLMETNRRVVEKYE 800

Human 379 378
Worm 801 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASP1	NP_001244047.1	CARD_CASP1-like	5..87	CDD:260036
CASP1	NP_001244047.1	CASc	153..402	CDD:214521	62/241 (26%)
csp-2	NP_001370851.1	pneumo_PspA	239..>533	CDD:411490	12/35 (34%)
		PHA03418	<475..>563	CDD:177646	20/65 (31%)
		CASc	581..824	CDD:237997	62/241 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161461451
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740