DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CARS1 and CysRS

DIOPT Version :9

Sequence 1:	XP_024304469.1	Gene:	CARS1 / 833	HGNCID:	1493	Length:	867	Species:	Homo sapiens
Sequence 2:	NP_611087.1	Gene:	CysRS / 36784	FlyBaseID:	FBgn0027091	Length:	741	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	439/774 - (56%)
Similarity:	530/774 - (68%)	Gaps:	51/774 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    95 RRVQPQWSPPAGTQPCRLHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDI 159
            :|.||.|..|......:|.|:|||||.||.|:|.||..||||.||||||||||||||||||||||
  Fly     3 KRGQPAWQAPEAVDRPKLKLFNSLTRQKEDFVPLDGNNVTWYSCGPTVYDASHMGHARSYISFDI 67

Human   160 LRRVLKDYFKFDVFYCMNITDIDDKIIKRARQNHLFEQY---REKRPEAAQLLEDVQAALKPFSV 221
            |||:|.|||.:::.|.|||||||||||:||||||||::|   .:|.| ..:||...:..|:.|..
  Fly    68 LRRILSDYFGYNIHYVMNITDIDDKIIRRARQNHLFDEYAAEAQKLP-LDELLGQQKEVLQRFQD 131

Human   222 KLNETTDPDKKQMLERIQHAVQLATEPLEKAVQSRLTGEEVNSCVEVLLEEAKDLLSDWLDSTLG 286
            ...:.||||||.||::....:..|.|.|.||| .:....|::....:.|.||||.:||||||..|
  Fly   132 TCAKNTDPDKKIMLDKTLQRMNDAVEALTKAV-GKGDEREISEKRLLYLNEAKDPISDWLDSLKG 195

Human   287 CDVTDNSIFSKLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSV 351
            ..:.||::|..||::||..||.||::||:||||||||||||||:||.|:|||:|||..|.:|.||
  Fly   196 AQINDNAVFEALPRYWEDQFHNDMKSLNILPPDVLTRVSEYVPQIVTFIQKIIDNGLAYAANNSV 260

Human   352 YFDTAKFASSEKHSYGKLVPEAVGDQKALQEGEGDLSISADRLSEKRSPNDFALWKASKPGEPSW 416
            |||...|...|||.|.||||||.||.|:||||||||||:.||||||||.||||||||||.|||.|
  Fly   261 YFDVNGFDKREKHHYAKLVPEAYGDTKSLQEGEGDLSIAEDRLSEKRSANDFALWKASKAGEPWW 325

Human   417 PCPWGKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTG 481
            ..|||||||||||||||||..:.|.:.|||.||.||:|||||||||||||.|....||:||||||
  Fly   326 DSPWGKGRPGWHIECSAMASDIFGPTFDIHTGGVDLKFPHHDNELAQSEAAFNESEWVKYFLHTG 390

Human   482 HLTIAGCKMSKSLKNFITIKDALKKHSGIHWLLPQTPQPPSHTCVMAVALGRIRALAVLCPPTAR 546
            ||||||||||||||||:||::||||||                                    |.
  Fly   391 HLTIAGCKMSKSLKNFVTIQEALKKHS------------------------------------AT 419

Human   547 QLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDILRAPV--DITGQFEKWGEEEAEL 609
            |||||||:||||||||||.||||.|.|||||||||||||||:.|..:  :...||:.|.|.||.|
  Fly   420 QLRLAFLLHSWKDTLDYSENTMEMATQYEKFLNEFFLNVKDLTRHVLSEEPRRQFDAWTEVEAAL 484

Human   610 NKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPNQALLENIALYLTHML 674
            .|.|.:.:..:|.:||||:|||:.::.:|.|||..|:|:...|.   |.|..||.|:|.|:|.:|
  Fly   485 QKKFSNAQVQVHASLCDNIDTRSALDAIRELVSVSNVYIRDNKT---RLNSLLLRNVATYITDLL 546

Human   675 KIFGAVE-EDSSLGFPV-GGPGTSLS---LEATVMPYLQVLSEFREGVRKIAREQKVPEILQLSD 734
            .:|||:. ....:|||| ||.|...:   ||.||:||:|.|:|||..||:.|:..|..:||:|.|
  Fly   547 HVFGAISGPRGGIGFPVSGGSGAQAAGADLETTVLPYVQSLAEFRYLVREQAKTLKAFDILKLCD 611

Human   735 ALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKEREEKRRVEEEKRKKKEEAARRKQEQEAAKL 799
            .||||:||.||||.||.:.....||||||::||:|||.|...|.||..:||...:...|..|||.
  Fly   612 DLRDNVLPNLGVRLEDKDIGKYAVKLVDRDSLLREREAKLAAEAEKAAEKERKKQAAAEAAAAKE 676

Human   800 AKMKIPPSEMFLSETDKYSKFDENGLPTHDMEGKELSKGQAKKLKKLFEAQEKLYKEYL 858
            |:.::.|.||||:||:|||.||||||||||.||||:||||.|||:||.:.||:.|.|||
  Fly   677 AQRRVNPKEMFLAETEKYSAFDENGLPTHDKEGKEVSKGQIKKLQKLQQQQEQRYNEYL 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CARS1	XP_024304469.1	GST_C_CysRS_N	3..76	CDD:198343
CARS1	XP_024304469.1	PTZ00399	91..858	CDD:240402	437/772 (57%)
CysRS	NP_611087.1	PTZ00399	2..737	CDD:240402	439/774 (57%)
CysRS	NP_611087.1	CysRS_core	21..437	CDD:173899	275/453 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146518
Domainoid	1	1.000	558	1.000	Domainoid score	I238
eggNOG	1	0.900	-	-		E1_COG0215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1328
Inparanoid	1	1.050	852	1.000	Inparanoid score	I434
Isobase	1	0.950	-	0	Normalized mean entropy	S696
OMA	1	1.010	-	-		QHG54140
OrthoDB	1	1.010	-	-		D480663at33208
OrthoFinder	1	1.000	-	-		FOG0000992
OrthoInspector	1	1.000	-	-		oto89596
orthoMCL	1	0.900	-	-		OOG6_100332
Panther	1	1.100	-	-	LDO	PTHR10890
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1431
SonicParanoid	1	1.000	-	-		X4186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750