DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CARS1 and eEF1delta

DIOPT Version :9

Sequence 1:	XP_024304469.1	Gene:	CARS1 / 833	HGNCID:	1493	Length:	867	Species:	Homo sapiens
Sequence 2:	NP_609361.1	Gene:	eEF1delta / 34363	FlyBaseID:	FBgn0032198	Length:	256	Species:	Drosophila melanogaster

Alignment Length:	166	Identity:	36/166 - (21%)
Similarity:	60/166 - (36%)	Gaps:	46/166 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   706 YLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDR------- 763
            |..::||..:....|....:..:.:.|.|.|...:...|.....:|:.|.|.|.|::.
  Fly    36 YSPLVSEIAKAREHIQNSLEKIDGVTLDDGLNSELAKRLAQLEGEHKELKTQVSLLNELLTATVK 100

Human   764 ---------NTLLKEREEKRRVEE-------------EKRKKKEEAARRKQEQEAAKLAKMK--- 803
                     |.:.||.|.:.:..|             :..::..||||.::|:.||..||..
  Fly   101 RLETQLKLTNGVSKEPEVEAKKPEANDDDDDVDLFGSDSEEEDGEAARIREERLAAYAAKKAKKV 165

Human   804 --IPPSEMFL------SETD------KYSKFDENGL 825
              |..|.:.|      .|||      :..|..::||
  Fly   166 QIIAKSNIILDVKPWDDETDLKVMETEIRKITQDGL 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CARS1	XP_024304469.1	GST_C_CysRS_N	3..76	CDD:198343
CARS1	XP_024304469.1	PTZ00399	91..858	CDD:240402	36/166 (22%)
eEF1delta	NP_609361.1	EF-1_beta_acid	134..>156	CDD:287546	5/21 (24%)
eEF1delta	NP_609361.1	EF1B	168..256	CDD:238181	9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2092
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900