| Sequence 1: | NP_003499.1 | Gene: | FZD9 / 8326 | HGNCID: | 4047 | Length: | 591 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001262037.1 | Gene: | fz2 / 40090 | FlyBaseID: | FBgn0016797 | Length: | 806 | Species: | Drosophila melanogaster |
| Alignment Length: | 609 | Identity: | 255/609 - (41%) |
|---|---|---|---|
| Similarity: | 338/609 - (55%) | Gaps: | 98/609 - (16%) |
- Green bases have known domain annotations that are detailed below.
|
Human 16 LAAGGAALEIGRFDPERGRGA--------APCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAE 72
Human 73 LAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSL 137
Human 138 DCARLPTRNDPHALCMEAPENATAGP-----AEPHKGLGMLPVAPRPARPPGDLGPGAGGSG--- 194
Human 195 -----------TCENP--EKFQYVEKSRSC----------------------------------- 211
Human 212 ----APRCG-PGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLS 271
Human 272 MCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTG---CTLVFLLLYYFGMASSLWWVV 333
Human 334 LTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAAL 398
Human 399 TGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKT-----GGTNTEKLEKLMVKIGVFSILYTVP 458
Human 459 ATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGIT 523
Human 524 SGVWVWSSKTFQTWQSLCYRKIAA 547 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FZD9 | NP_003499.1 | TM helix 1 | 230..255 | CDD:320164 | 14/24 (58%) |
| TM helix 2 | 264..285 | CDD:320164 | 10/20 (50%) | ||
| TM helix 3 | 314..340 | CDD:320164 | 19/25 (76%) | ||
| TM helix 4 | 357..373 | CDD:320164 | 7/15 (47%) | ||
| TM helix 5 | 395..425 | CDD:320164 | 15/29 (52%) | ||
| TM helix 6 | 444..471 | CDD:320164 | 19/26 (73%) | ||
| TM helix 7 | 503..528 | CDD:320164 | 15/24 (63%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 532..537 | 2/4 (50%) | |||
| Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 | 554..591 | ||||
| CRD_FZ | 35..161 | CDD:321937 | 61/133 (46%) | ||
| Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 | 58..172 | 51/118 (43%) | |||
| 7tmF_FZD9 | 221..542 | CDD:320164 | 162/328 (49%) | ||
| fz2 | NP_001262037.1 | CRD_FZ5_like | 63..182 | CDD:143565 | 59/118 (50%) |
| Frizzled | 308..618 | CDD:279827 | 162/327 (50%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D237456at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X126 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.820 | |||||