DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FZD9 and Corin

DIOPT Version :10

Sequence 1:NP_003499.1 Gene:FZD9 / 8326 HGNCID:4047 Length:591 Species:Homo sapiens
Sequence 2:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster


Alignment Length:304 Identity:70/304 - (23%)
Similarity:103/304 - (33%) Gaps:97/304 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    33 GRGAAP--CQAVEIPMCRG--IGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLC 93
            |:..||  |..:.:..|:|  |.||.|..||.:||..|.|...:|..:..||...|:..:..|||
  Fly   771 GKNPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLC 835

Human    94 SLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCAR----------------- 141
            :|:.|.| .|....:|.|:.:|.:...||....:.|....|:.|:|..                 
  Fly   836 TLFVPKC-GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVR 899

Human   142 ---------------------LPTRN--DPHALCMEAPENA---TAGPAEPHKGLGMLPVAPRPA 180
                                 ||...  |.|..||:..:.|   ..||.|.:.|....       
  Fly   900 EVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQC------- 957

Human   181 RPPGDLGPGAGGSGTCENPEKFQYVEKSRSC---APR---CGPGV-EVF--------------WS 224
                     .|....|:......|.:..|:|   :.|   .|.|| ||:              |.
  Fly   958 ---------IGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWD 1013

Human   225 RRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPII 268
            |.....|:..:..:||:    .|.:|||        |...||::
  Fly  1014 RAVSPSAVCSILGYSAV----NATSVLT--------QLTHRPLL 1045

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FZD9NP_003499.1 CRD_FZ 35..161 CDD:470581 42/172 (24%)
Required for Wnt-activated receptor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 58..172 37/156 (24%)
7tmF_FZD9 221..542 CDD:320164 13/62 (21%)
TM helix 1 230..255 CDD:320164 7/24 (29%)
TM helix 2 264..285 CDD:320164 2/5 (40%)
TM helix 3 314..340 CDD:320164
TM helix 4 357..373 CDD:320164
TM helix 5 395..425 CDD:320164
TM helix 6 444..471 CDD:320164
TM helix 7 503..528 CDD:320164
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 532..537
Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250|UniProtKB:Q8K4C8 554..591
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 33/116 (28%)
LDLa 911..942 CDD:238060 7/30 (23%)
LDLa 945..979 CDD:238060 8/49 (16%)
SR 980..>1034 CDD:214555 12/57 (21%)
Tryp_SPc 1104..1346 CDD:238113
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.