DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FZD9 and Corin

DIOPT Version :9

Sequence 1:	NP_003499.1	Gene:	FZD9 / 8326	HGNCID:	4047	Length:	591	Species:	Homo sapiens
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	304	Identity:	70/304 - (23%)
Similarity:	103/304 - (33%)	Gaps:	97/304 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    33 GRGAAP--CQAVEIPMCRG--IGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLC 93
            |:..||  |..:.:..|:|  |.||.|..||.:||..|.|...:|..:..||...|:..:..|||
  Fly   771 GKNPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLC 835

Human    94 SLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCAR----------------- 141
            :|:.|.| .|....:|.|:.:|.:...||....:.|....|:.|:|..
  Fly   836 TLFVPKC-GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVR 899

Human   142 ---------------------LPTRN--DPHALCMEAPENA---TAGPAEPHKGLGMLPVAPRPA 180
                                 ||...  |.|..||:..:.|   ..||.|.:.|....
  Fly   900 EVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQC------- 957

Human   181 RPPGDLGPGAGGSGTCENPEKFQYVEKSRSC---APR---CGPGV-EVF--------------WS 224
                     .|....|:......|.:..|:|   :.|   .|.|| ||:              |.
  Fly   958 ---------IGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWD 1013

Human   225 RRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPII 268
            |.....|:..:..:||:    .|.:|||        |...||::
  Fly  1014 RAVSPSAVCSILGYSAV----NATSVLT--------QLTHRPLL 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FZD9	NP_003499.1	TM helix 1	230..255	CDD:320164	7/24 (29%)
		TM helix 2	264..285	CDD:320164	2/5 (40%)
		TM helix 3	314..340	CDD:320164
		TM helix 4	357..373	CDD:320164
		TM helix 5	395..425	CDD:320164
		TM helix 6	444..471	CDD:320164
		TM helix 7	503..528	CDD:320164
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	532..537
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250\|UniProtKB:Q8K4C8	554..591
		CRD_FZ	35..161	CDD:321937	42/172 (24%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000250\|UniProtKB:Q8K4C8	58..172		37/156 (24%)
		7tmF_FZD9	221..542	CDD:320164	13/62 (21%)
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	33/116 (28%)
		LDLa	911..942	CDD:238060	7/30 (23%)
		LDLa	945..979	CDD:238060	8/49 (16%)
		SR	980..>1034	CDD:214555	12/57 (21%)
		SRCR	992..1086	CDD:278931	16/66 (24%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810