Protein Alignment PCDH11Y and cdh-10

DIOPT Version :10

• Sequence 1: NP_116755.1
• Gene: PCDH11Y / 83259
• HGNCID: 15813
• Length: 1340
• Species: Homo sapiens
• Sequence 2: NP_500204.3
• Gene: cdh-10 / 183476
• WormBaseID: WBGene00000402
• Length: 1775
• Species: Caenorhabditis elegans
• Alignment Length: 1015
• Identity: 227/1015 - (22%)
• Similarity: 379/1015 - (37%)
• Gaps: 251/1015 - (24%)

Human    89 LTTTMQFKLVYKTGDVPL---IRIEEDTGEIFTTGARIDREKL--------CAGIPRDEHCFYEV 142
            ||.|: .::..|.|..||   .:|||.:|:.....|..||||.        ...:..|....|.:
 Worm   772 LTETI-VEIDVKNGQEPLENEQKIEEKSGKSRVLEATFDREKSEDFEIQLDEKNMKLDLKSMYGI 835

Human   143 E-------------------VAILPDEI--FRLV----------KIRFLIEDIND---------- 166
            :                   |.:.||.:  .||:          ||..|:..|:.
 Worm   836 DEKGQKVTLDPTSITVTSTHVQLTPDSLKSLRLIGMTLKNPDSQKINILVRLISSPEYLKNQEKL 900

Human   167 -NAPLFPATVINISIP---ENSAINSKYTLPAAVDPDVGI-NGVQNYELIKSQNIFGL-----DV 221
             ..|::|       :|   ||..|:.:.....|....||: ..|....|.:...|.||     |.
 Worm   901 AQRPIYP-------MPWTRENPVIHVELREELAQGQVVGVFPAVSQGNLSREIQISGLMSDAFDF 958

Human   222 IETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEI 286
            ..|....|:.|.|..:.||..:| |:.:.:...:.||   .|.|||.|.|||.:||.||....:.
 Worm   959 NGTTGELKIKQRIDYETLDEAQK-TFNLTLSSGENGF---KSEAILMVQVTDVDDNSPVVDVGDA 1019

Human   287 E-VSIPENAPVGTSVTQLHATDADIGENAKIHF---SFSNLVSNIARRLFHLNATTGLITI---- 343
            | :|:|||...||.:.:...||.|..|:.::..   ...|.::||..     :.||..::|
 Worm  1020 EMISLPENLSAGTKIAEFDVTDPDGSESYQVELEGDGSKNFMANITS-----SNTTATLSIFIAE 1079

Human   344 KEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPL 408
            ...:|||......|||...|......:.::.:.|.|||||.|..:     ..:.|..|: |::|.
 Worm  1080 NAKIDRETQDFIALLVKILDISGNSEKIILPIRVLDVNDNAPQFE-----QNLYDVEVM-EDLPS 1138

Human   409 NTKIALITVTDKDADHNGRVTCF--------TDHEIPFRLRPVFSNQFLLENAAYL-DYESTKEY 464
            ...|..:...|.||........:        ||..|     .|.|...:::.:..| .....:.|
 Worm  1139 GMVIHRVHAMDSDAPGAASTVNYQISNPSDVTDDVI-----SVNSTSGVVQISGSLWGMPREQPY 1198

Human   465 AIKLLAADAGKPPLNQSAMLFIKV--KDE--NDNAPVFTQSFVTVSIPENNSPGIQLMKVSAT-- 523
            ..:::|.|.|.|.||.:::|.::|  |||  .:.|..|.:....|.|.||.:|..::....|.
 Worm  1199 KFQVIAQDFGAPGLNSTSILSLRVRNKDEVVTEEAVEFEEITQEVVIQENLAPDTKIYTAKAVLR 1263

Human   524 DADSGPNAEINY----LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTS 584
            ...|....::.|    ||..:..|.|::|:.:|.:.|||.:|.|:..:|...|.|.::|...:||
 Worm  1264 GIPSKTRGKVVYTLKDLLSSEKEPIFAVDKDSGDIFVVKPIDFEERSEYTLLITAFNSGNELVTS 1328

Human   585 NVTVFVSIIDQNDNSPVFTHNEYK-FYVPENLPRHGTVGLITVTDPDYGDNSAVTLSIL------ 642
            :..:.:.:.:.:||.|.|..:... |.||:|..:...:|.:|..|.|:   |.:...:|
 Worm  1329 STLLKIRVENLDDNEPEFLPSALPIFQVPKNTSKPTAIGRLTARDADF---SPIFYHLLPNCGTP 1390

Human   643 DENDDFTIDSQTG--VIRPNISFDREKQE---------------SYTFY---------VKAE--- 678
            :.:|:|.||::.|  |..|.:....:..|               |..|:         ||.|
 Worm  1391 ESSDNFNIDAEFGEIVYEPKVDPSSKMTEAEVCFIATSQKNLDTSEVFFDANSKNFKRVKVEFVG 1455

Human   679 -------DGGRVSRSSSAKVTINVV-DVNDNKPV-------------------FIVPPYNYSYEL 716
                   :.|:::...|...:|:.| ||.|...:                   |:...|....::
 Worm  1456 DSVDSVANSGKINNGFSGNQSISSVGDVLDRVEIPMNLGAAAGAQDYEQKSLNFVPANYELGRDM 1520

Human   717 VLP------STNPGTVVFQVIAVDNDTGM-NAEVRYSIVGGNTRDLFAI--DQETGNITLMEKCD 772
            :.|      :.|.|.:|.....:|...|: .||:.....|...:.|..|  |::...:..|.:
 Worm  1521 ISPEGAVELNKNTGELVANGKILDTPQGVYTAEIGRGDGGEGVKQLHHIRNDRKLRYVLSMSR-- 1583

Human   773 VTDLG-----LHRVLVKANDLGQPDS-------------------------LFSVVIVNLFVNES 807
             .:.|     ..|.:::|  :|:.|.                         .|.:...|..::|:
 Worm  1584 -NEFGANLEKFRRQILEA--IGKDDQKAGKQLEIHFDEPKADRKNSTWTSVCFYLTRQNAILDEN 1645

Human   808 VTNATL------------INELVRKSIEAPVTPNTEIADVSSPTSDY---VKILVAAVAGTITVV 857
            ..::.:            |.::....:.||....|.....||..||.   ..||:..|...|..:
 Worm  1646 QASSIISPSNGHISKLHHIFKVQNVDMCAPKPSATSSESTSSSNSDIPLNTLILIGVVGLLIIAL 1710

Human   858 VVIFITAVVRCRQAPHLKAAQKNMQ-------NSEWATPN 890
            :.:.|......|...:||  ||..|       .|.:.:||
 Worm  1711 LALLIYVCCVSRYQRYLK--QKTDQLRCSSSAGSYYKSPN 1748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PCDH11Y	NP_116755.1	Cadherin_2	60..134	CDD:462413	16/55 (29%)
		Cadherin_repeat	175..277	CDD:206637	31/110 (28%)
		Cadherin_repeat	285..383	CDD:206637	28/105 (27%)
		CA	416..496	CDD:214520	21/92 (23%)
		Cadherin_repeat	504..598	CDD:206637	25/99 (25%)
		Cadherin_repeat	606..701	CDD:206637	29/138 (21%)
		Cadherin_repeat	713..804	CDD:206637	20/129 (16%)
		Protocadherin	807..1008	CDD:462451	22/106 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1052..1112
		FAM47	<1180..1247	CDD:405345
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1321..1340
cdh-10	NP_500204.3	Cadherin_repeat	916..1010	CDD:206637	28/97 (29%)
		Cadherin_repeat	1022..1119	CDD:206637	27/101 (27%)
		Cadherin_repeat	1128..1222	CDD:206637	22/99 (22%)
		Cadherin_repeat	1242..1342	CDD:206637	25/99 (25%)