DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FZD8 and smo

DIOPT Version :9

Sequence 1:	NP_114072.1	Gene:	FZD8 / 8325	HGNCID:	4046	Length:	694	Species:	Homo sapiens
Sequence 2:	NP_523443.1	Gene:	smo / 33196	FlyBaseID:	FBgn0003444	Length:	1036	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	135/597 - (22%)
Similarity:	218/597 - (36%)	Gaps:	180/597 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    61 TQDEAGLEVHQFWPLVEI-QCSPDLKFFLCSMYTPIC----------LEDYKK---PLPPCRSVC 111
            |:.|...:::.::.|..: :|...::.|||:::.|.|          |..|:.   .:.|||
  Fly   119 TEKELNDKLNDYYALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLPSYEMCRITMEPCR--- 180

Human   112 ERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQP 176
                     ::....| :|..:||                |.|...|...:
  Fly   181 ---------ILYNTTF-FPKFLRC----------------NETLFPTKCTN-------------- 205

Human   177 PSGSGHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMV-- 239
                      |||     |.:..|.|                              ||.:|:|
  Fly   206 ----------GAR-----GMKFNGTG------------------------------QCLSPLVPT 225

Human   240 SVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDME 304
            ..|:..:|        .|..|.:.|.:|.::.||.......||....:|.:|....||||.||.:
  Fly   226 DTSASYYP--------GIEGCGVRCKDPLYTDDEHRQIHKLIGWAGSICLLSNLFVVSTFFIDWK 282

Human   305 RF-KYPERPIIFLSACYLFVSVGYLVRLVAG-HEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGA 367
            .. |||...:.:::.|:|...||:|::..:| .|.:.|.
  Fly   283 NANKYPAVIVFYINLCFLIACVGWLLQFTSGSREDIVCR-------------------------- 321

Human   368 GGPGGRGEYEELGAVEQHVRYETTGPAL-CTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGN 431
              ..|...:.|          .|.|..| |.|:|:|||:|..|..:|:|.|:..|...| |....
  Fly   322 --KDGTLRHSE----------PTAGENLSCIVIFVLVYYFLTAGMVWFVFLTYAWHWRA-MGHVQ 373

Human   432 EAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIG 496
            :.|.....||||.||.:|.|.:|..:|.|.|||:.:.|||:||..:.....|.:|.||...:.||
  Fly   374 DRIDKKGSYFHLVAWSLPLVLTITTMAFSEVDGNSIVGICFVGYINHSMRAGLLLGPLCGVILIG 438

Human   497 TMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRW 561
            ..|:..|.|.||.::.........:.::|:..:::|:|:..:|..|...|.:||...|..:...|
  Fly   439 GYFITRGMVMLFGLKHFANDIKSTSASNKIHLIIMRMGVCALLTLVFILVAIACHVTEFRHADEW 503

Human   562 ----------------EATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLV-VGITSGVWVWSGKT 609
                            |...:|..        ..||...|..| :.:||. .||....|.|:..:
  Fly   504 AQSFRQFIICKISSVFEEKSSCRI--------ENRPSVGVLQL-HLLCLFSSGIVMSTWCWTPSS 559

Human   610 LESWRSLCTRCC 621
            :|:|:....:.|
  Fly   560 IETWKRYIRKKC 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FZD8	NP_114072.1	CRD_FZ8	31..155	CDD:143570	19/107 (18%)
		Palmitate-binding groove. /evidence=ECO:0000250	71..78		1/6 (17%)
		Wnt-binding. /evidence=ECO:0000250	95..100		2/14 (14%)
		Wnt-binding. /evidence=ECO:0000250	147..152		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..226		7/70 (10%)
		7tmF_FZD8	267..618	CDD:320378	98/370 (26%)
		TM helix 1	277..301	CDD:320378	8/23 (35%)
		TM helix 2	310..331	CDD:320378	5/20 (25%)
		TM helix 3	397..419	CDD:320378	10/21 (48%)
		TM helix 4	440..456	CDD:320378	9/15 (60%)
		TM helix 5	478..501	CDD:320378	7/22 (32%)
		TM helix 6	534..556	CDD:320378	7/21 (33%)
		TM helix 7	579..604	CDD:320378	8/25 (32%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	608..613		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	648..668
		PDZ-binding	692..694
smo	NP_523443.1	CRD_SMO	86..221	CDD:143560	29/189 (15%)
smo	NP_523443.1	Frizzled	246..568	CDD:279827	97/369 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D509772at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820