| Sequence 1: | NP_003498.1 | Gene: | FZD7 / 8324 | HGNCID: | 4045 | Length: | 574 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001261836.1 | Gene: | fz / 45307 | FlyBaseID: | FBgn0001085 | Length: | 612 | Species: | Drosophila melanogaster |
| Alignment Length: | 565 | Identity: | 270/565 - (47%) |
|---|---|---|---|
| Similarity: | 347/565 - (61%) | Gaps: | 56/565 - (9%) |
- Green bases have known domain annotations that are detailed below.
|
Human 28 AGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKV 92
Human 93 QCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAG 157
Human 158 EICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGAS----------DGRGRP--AFPFSC 210
Human 211 PRQLKVPPYLGYRF-LGER---DCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFT 271
Human 272 VLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSD-------DGYRTVAQ 329
Human 330 GTKK-EGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKT 393
Human 394 ITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDG 458
Human 459 TKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCP----PGH 519
Human 520 FPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRL 564 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FZD7 | NP_003498.1 | CRD_FZ7 | 45..169 | CDD:143575 | 74/123 (60%) |
| 7tmF_FZD7 | 243..573 | CDD:320374 | 170/334 (51%) | ||
| TM helix 1 | 253..277 | CDD:320374 | 14/23 (61%) | ||
| TM helix 2 | 286..307 | CDD:320374 | 11/20 (55%) | ||
| TM helix 3 | 337..359 | CDD:320374 | 12/21 (57%) | ||
| TM helix 4 | 380..396 | CDD:320374 | 11/15 (73%) | ||
| TM helix 5 | 418..441 | CDD:320374 | 9/22 (41%) | ||
| TM helix 6 | 472..494 | CDD:320374 | 11/21 (52%) | ||
| TM helix 7 | 523..548 | CDD:320374 | 11/24 (46%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 552..557 | 2/4 (50%) | |||
| PDZ-binding | 572..574 | ||||
| fz | NP_001261836.1 | CRD_FZ1_like | 51..167 | CDD:143567 | 71/116 (61%) |
| Frizzled | 237..564 | CDD:279827 | 166/327 (51%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 158 | 1.000 | Domainoid score | I4112 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 531 | 1.000 | Inparanoid score | I1219 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S3599 |
| OMA | 1 | 1.010 | - | - | QHG48699 | |
| OrthoDB | 1 | 1.010 | - | - | D167933at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001848 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41535 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_104642 | |
| Panther | 1 | 1.100 | - | - | O | PTHR11309 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3233 |
| SonicParanoid | 1 | 1.000 | - | - | X126 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 15 | 14.820 | |||||