| Sequence 1: | NP_003498.1 | Gene: | FZD7 / 8324 | HGNCID: | 4045 | Length: | 574 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001262037.1 | Gene: | fz2 / 40090 | FlyBaseID: | FBgn0016797 | Length: | 806 | Species: | Drosophila melanogaster |
| Alignment Length: | 649 | Identity: | 280/649 - (43%) |
|---|---|---|---|
| Similarity: | 366/649 - (56%) | Gaps: | 137/649 - (21%) |
- Green bases have known domain annotations that are detailed below.
|
Human 15 LCALVLALLGALSAGAGAQPYHGEKGISVPDHGF--------------------CQPISIPLCTD 59
Human 60 IAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIPPCRSL 123
Human 124 CERARQGCEALMNKFGFQWPERLRCENFPVHG-AGEICVGQ---------NTSDGSGGPG----- 173
Human 174 -----------GGPTAYPTAPYLPDLPFTALPPGASDG-------RGRPA--------------- 205
Human 206 FPFSC-------------PRQLKVP----PYLGY------RFLGERDCGAPCE-PGRANGLMYFK 246
Human 247 EEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVA-GFLLE 310
Human 311 DRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIE 375
Human 376 ANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFL 440
Human 441 LAGFVSLFRIRTIMKHD-----GTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWE 500
Human 501 RTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRL 564 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FZD7 | NP_003498.1 | CRD_FZ7 | 45..169 | CDD:143575 | 64/154 (42%) |
| 7tmF_FZD7 | 243..573 | CDD:320374 | 181/328 (55%) | ||
| TM helix 1 | 253..277 | CDD:320374 | 12/23 (52%) | ||
| TM helix 2 | 286..307 | CDD:320374 | 14/21 (67%) | ||
| TM helix 3 | 337..359 | CDD:320374 | 16/21 (76%) | ||
| TM helix 4 | 380..396 | CDD:320374 | 9/15 (60%) | ||
| TM helix 5 | 418..441 | CDD:320374 | 16/22 (73%) | ||
| TM helix 6 | 472..494 | CDD:320374 | 17/21 (81%) | ||
| TM helix 7 | 523..548 | CDD:320374 | 11/24 (46%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 552..557 | 3/4 (75%) | |||
| PDZ-binding | 572..574 | ||||
| fz2 | NP_001262037.1 | CRD_FZ5_like | 63..182 | CDD:143565 | 61/118 (52%) |
| Frizzled | 308..618 | CDD:279827 | 179/323 (55%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X126 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.810 | |||||