| Sequence 1: | NP_003498.1 | Gene: | FZD7 / 8324 | HGNCID: | 4045 | Length: | 574 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001300437.1 | Gene: | mom-5 / 172856 | WormBaseID: | WBGene00003397 | Length: | 570 | Species: | Caenorhabditis elegans |
| Alignment Length: | 585 | Identity: | 227/585 - (38%) |
|---|---|---|---|
| Similarity: | 320/585 - (54%) | Gaps: | 67/585 - (11%) |
- Green bases have known domain annotations that are detailed below.
|
Human 18 LVLALLGALSAGAGAQPYHGEKGISVPD----HGF-----CQPISIPLCTDIAYNQTILPNLLGH 73
Human 74 TNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKF 138
Human 139 GFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGR 203
Human 204 PAF-PFSCPRQLKVP-------PYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVW 260
Human 261 SVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYR 325
Human 326 TVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPA 390
Human 391 VKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMK 455
Human 456 HDGTKTE----KLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCK------- 509
Human 510 ---SYAV-PCPPGHFPP--MSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSS 568
Human 569 568 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FZD7 | NP_003498.1 | CRD_FZ7 | 45..169 | CDD:143575 | 70/132 (53%) |
| 7tmF_FZD7 | 243..573 | CDD:320374 | 134/343 (39%) | ||
| TM helix 1 | 253..277 | CDD:320374 | 10/23 (43%) | ||
| TM helix 2 | 286..307 | CDD:320374 | 6/20 (30%) | ||
| TM helix 3 | 337..359 | CDD:320374 | 10/21 (48%) | ||
| TM helix 4 | 380..396 | CDD:320374 | 8/15 (53%) | ||
| TM helix 5 | 418..441 | CDD:320374 | 7/22 (32%) | ||
| TM helix 6 | 472..494 | CDD:320374 | 6/21 (29%) | ||
| TM helix 7 | 523..548 | CDD:320374 | 9/24 (38%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 552..557 | 3/4 (75%) | |||
| PDZ-binding | 572..574 | ||||
| mom-5 | NP_001300437.1 | CRD_FZ1_like | 35..147 | CDD:143567 | 64/114 (56%) |
| 7tmF_Frizzled_SMO | 219..550 | CDD:320089 | 130/335 (39%) | ||
| TM helix 1 | 228..253 | CDD:320089 | 10/24 (42%) | ||
| TM helix 2 | 262..282 | CDD:320089 | 6/19 (32%) | ||
| TM helix 3 | 312..338 | CDD:320089 | 12/25 (48%) | ||
| TM helix 4 | 355..371 | CDD:320089 | 8/15 (53%) | ||
| TM helix 5 | 393..422 | CDD:320089 | 9/28 (32%) | ||
| TM helix 6 | 446..473 | CDD:320089 | 10/26 (38%) | ||
| TM helix 7 | 512..537 | CDD:320089 | 9/24 (38%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 251 | 1.000 | Domainoid score | I1282 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 401 | 1.000 | Inparanoid score | I1230 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S3599 |
| OMA | 1 | 1.010 | - | - | QHG48699 | |
| OrthoDB | 1 | 1.010 | - | - | D167933at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001848 | |
| OrthoInspector | 1 | 1.000 | - | - | otm15852 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_104642 | |
| Panther | 1 | 1.100 | - | - | O | PTHR11309 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X126 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| 14 | 13.790 | |||||