| Sequence 1: | NP_036325.2 | Gene: | FZD4 / 8322 | HGNCID: | 4042 | Length: | 537 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_072145.1 | Gene: | Fzd4 / 64558 | RGDID: | 71017 | Length: | 538 | Species: | Rattus norvegicus |
| Alignment Length: | 538 | Identity: | 523/538 - (97%) |
|---|---|---|---|
| Similarity: | 528/538 - (98%) | Gaps: | 1/538 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1 MAWRGAGPSVPGAPGGVGLSLG-LLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMP 64
Human 65 NLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCE 129
Human 130 PVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWV 194
Human 195 KRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLS 259
Human 260 MCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILT 324
Human 325 LTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTG 389
Human 390 FVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIAC 454
Human 455 YFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKR 519
Human 520 EKRGNGWVKPGKGSETVV 537 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FZD4 | NP_036325.2 | CRD_FZ4 | 42..167 | CDD:143557 | 122/124 (98%) |
| 7tmF_FZD4 | 209..509 | CDD:320166 | 297/299 (99%) | ||
| TM helix 1 | 218..243 | CDD:320166 | 23/24 (96%) | ||
| TM helix 2 | 252..273 | CDD:320166 | 20/20 (100%) | ||
| TM helix 3 | 303..329 | CDD:320166 | 25/25 (100%) | ||
| TM helix 4 | 346..362 | CDD:320166 | 15/15 (100%) | ||
| TM helix 5 | 384..413 | CDD:320166 | 28/28 (100%) | ||
| TM helix 6 | 433..460 | CDD:320166 | 26/26 (100%) | ||
| TM helix 7 | 470..495 | CDD:320166 | 24/24 (100%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 499..504 | 4/4 (100%) | |||
| PDZ-binding | 535..537 | 1/1 (100%) | |||
| Fzd4 | NP_072145.1 | CRD_FZ4 | 43..168 | CDD:143557 | 122/124 (98%) |
| Frizzled | 211..510 | CDD:279827 | 296/298 (99%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 500..505 | 4/4 (100%) | |||
| PDZ-binding | 536..538 | 1/1 (100%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C83696958 | |
| Domainoid | 1 | 1.000 | 605 | 1.000 | Domainoid score | I4757 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| HGNC | 1 | 1.500 | - | - | ||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H7325 | |
| Inparanoid | 1 | 1.050 | 1079 | 1.000 | Inparanoid score | I4853 |
| NCBI | 1 | 1.000 | - | - | ||
| OMA | 1 | 1.010 | - | - | QHG50792 | |
| OrthoDB | 1 | 1.010 | - | - | D106057at32523 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0012161 | |
| OrthoInspector | 1 | 1.000 | - | - | oto137155 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_109675 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR11309 |
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 1 | 1.000 | - | - | X10059 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| 18 | 18.270 | |||||