Protein Alignment FZD4 and Fzd4

DIOPT Version :10

• Sequence 1: NP_036325.2
• Gene: FZD4 / 8322
• HGNCID: 4042
• Length: 537
• Species: Homo sapiens
• Sequence 2: NP_072145.1
• Gene: Fzd4 / 64558
• RGDID: 71017
• Length: 538
• Species: Rattus norvegicus
• Alignment Length: 538
• Identity: 523/538 - (97%)
• Similarity: 528/538 - (98%)
• Gaps: 1/538 - (0%)

Human     1 MAWRGAGPSVPGAPGGVGLSLG-LLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMP 64
            |||:|.||||.|.||||.|.|| ||||||||..||.|||||||||||||||:|||||||||||||
  Rat     1 MAWQGTGPSVRGMPGGVRLRLGLLLLQLLLLQRPALGFGDEEERRCDPIRIAMCQNLGYNVTKMP 65

Human    65 NLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCE 129
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 NLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCE 130

Human   130 PVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWV 194
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 PVLKEFGFAWPDSLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWV 195

Human   195 KRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLS 259
            ||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
  Rat   196 KRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSRFSYPERPIIFLS 260

Human   260 MCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILT 324
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 MCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILT 325

Human   325 LTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTG 389
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
  Rat   326 LTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQSLDALTG 390

Human   390 FVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIAC 454
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 FVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIAC 455

Human   455 YFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKR 519
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 YFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKR 520

Human   520 EKRGNGWVKPGKGSETVV 537
            |||||||||||||:||||
  Rat   521 EKRGNGWVKPGKGNETVV 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FZD4	NP_036325.2	CRD_FZ4	42..167	CDD:143557	122/124 (98%)
		7tmF_FZD4	209..509	CDD:320166	297/299 (99%)
		TM helix 1	218..243	CDD:320166	23/24 (96%)
		TM helix 2	252..273	CDD:320166	20/20 (100%)
		TM helix 3	303..329	CDD:320166	25/25 (100%)
		TM helix 4	346..362	CDD:320166	15/15 (100%)
		TM helix 5	384..413	CDD:320166	28/28 (100%)
		TM helix 6	433..460	CDD:320166	26/26 (100%)
		TM helix 7	470..495	CDD:320166	24/24 (100%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	499..504		4/4 (100%)
		PDZ-binding	535..537		1/1 (100%)
Fzd4	NP_072145.1	CRD_FZ4	43..168	CDD:143557	122/124 (98%)
		7tmF_FZD4	210..510	CDD:320166	297/299 (99%)
		TM helix 1	219..244	CDD:320166	23/24 (96%)
		TM helix 2	253..274	CDD:320166	20/20 (100%)
		TM helix 3	304..330	CDD:320166	25/25 (100%)
		TM helix 4	347..363	CDD:320166	15/15 (100%)
		TM helix 5	385..414	CDD:320166	28/28 (100%)
		TM helix 6	434..461	CDD:320166	26/26 (100%)
		TM helix 7	471..496	CDD:320166	24/24 (100%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	500..505		4/4 (100%)
		PDZ-binding	536..538		1/1 (100%)