| Sequence 1: | NP_036325.2 | Gene: | FZD4 / 8322 | HGNCID: | 4042 | Length: | 537 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_511068.2 | Gene: | fz4 / 31659 | FlyBaseID: | FBgn0027342 | Length: | 705 | Species: | Drosophila melanogaster |
| Alignment Length: | 550 | Identity: | 189/550 - (34%) |
|---|---|---|---|
| Similarity: | 279/550 - (50%) | Gaps: | 93/550 - (16%) |
- Green bases have known domain annotations that are detailed below.
|
Human 43 RRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCT 107
Human 108 EKINI-PIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVP--- 168
Human 169 --------------LPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFT 219
Human 220 DIWMAVWASLCF-ISTAFTVLTFLIDSSRFSYPE-----RPIIFLSMCYNIYSIAYIVRLTVGRE 278
Human 279 RISCDFEEAA--EPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIE 341
Human 342 MHS--SYFHI-------------------------------AAWAIPAVKTIVILIMRLVDADEL 373
Human 374 TGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKT--DKLERLMVK 436
Human 437 ----IGVFSVLYTVPATCVIACYFYEISNWALFRYSAD-DSNMAVEMLKIFMSLLVGITSGMWIW 496
Human 497 --SAKTLHTWQKCSNRLVNSGK-VKREKRG 523 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FZD4 | NP_036325.2 | CRD_FZ4 | 42..167 | CDD:143557 | 75/124 (60%) |
| 7tmF_FZD4 | 209..509 | CDD:320166 | 95/349 (27%) | ||
| TM helix 1 | 218..243 | CDD:320166 | 6/25 (24%) | ||
| TM helix 2 | 252..273 | CDD:320166 | 5/25 (20%) | ||
| TM helix 3 | 303..329 | CDD:320166 | 13/25 (52%) | ||
| TM helix 4 | 346..362 | CDD:320166 | 6/46 (13%) | ||
| TM helix 5 | 384..413 | CDD:320166 | 8/28 (29%) | ||
| TM helix 6 | 433..460 | CDD:320166 | 7/30 (23%) | ||
| TM helix 7 | 470..495 | CDD:320166 | 7/25 (28%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 499..504 | 2/4 (50%) | |||
| PDZ-binding | 535..537 | ||||
| fz4 | NP_511068.2 | CRD_FZ4 | 43..169 | CDD:143557 | 75/124 (60%) |
| 7tm_4 | 223..544 | CDD:304433 | 91/332 (27%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165160288 | |
| Domainoid | 1 | 1.000 | 148 | 1.000 | Domainoid score | I4504 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG3577 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D237456at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 1 | 0.900 | - | - | OOG6_109675 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR11309 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 7 | 6.750 | |||||