| Sequence 1: | NP_036325.2 | Gene: | FZD4 / 8322 | HGNCID: | 4042 | Length: | 537 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_503965.2 | Gene: | cfz-2 / 178768 | WormBaseID: | WBGene00000478 | Length: | 578 | Species: | Caenorhabditis elegans |
| Alignment Length: | 539 | Identity: | 191/539 - (35%) |
|---|---|---|---|
| Similarity: | 291/539 - (53%) | Gaps: | 78/539 - (14%) |
- Green bases have known domain annotations that are detailed below.
|
Human 27 LLLLLGPARG-FGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGC 90
Human 91 SSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQND-- 153
Human 154 -------------------HNH------------MCMEGPG------DEEVPLPHKTPIQPGEEC 181
Human 182 HSVGTNSDQYIWVKRS-----LNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTF 241
Human 242 LIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTG--CAI 304
Human 305 IFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVD 369
Human 370 ADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTD---KLE 431
Human 432 RLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYS----------ADDSNMAVEMLKIFMSLL 486
Human 487 VGITSGMWIWSAKTLHTWQ 505 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FZD4 | NP_036325.2 | CRD_FZ4 | 42..167 | CDD:143557 | 51/163 (31%) |
| 7tmF_FZD4 | 209..509 | CDD:320166 | 122/312 (39%) | ||
| TM helix 1 | 218..243 | CDD:320166 | 10/24 (42%) | ||
| TM helix 2 | 252..273 | CDD:320166 | 6/20 (30%) | ||
| TM helix 3 | 303..329 | CDD:320166 | 18/25 (72%) | ||
| TM helix 4 | 346..362 | CDD:320166 | 6/15 (40%) | ||
| TM helix 5 | 384..413 | CDD:320166 | 10/28 (36%) | ||
| TM helix 6 | 433..460 | CDD:320166 | 15/26 (58%) | ||
| TM helix 7 | 470..495 | CDD:320166 | 7/24 (29%) | ||
| Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 | 499..504 | 3/4 (75%) | |||
| PDZ-binding | 535..537 | ||||
| cfz-2 | NP_503965.2 | CRD_FZ5_like | 24..146 | CDD:143565 | 46/121 (38%) |
| Frizzled | 230..532 | CDD:279827 | 121/308 (39%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D237456at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 1 | 1.000 | - | - | otm14824 | |
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.920 | |||||