Protein Alignment FZD1 and fz2

DIOPT Version :9

• Sequence 1: NP_003496.1
• Gene: FZD1 / 8321
• HGNCID: 4038
• Length: 647
• Species: Homo sapiens
• Sequence 2: NP_001262037.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 806
• Species: Drosophila melanogaster
• Alignment Length: 643
• Identity: 273/643 - (42%)
• Similarity: 350/643 - (54%)
• Gaps: 143/643 - (22%)

Human    76 GQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGH 140
            |.|....|.||...|..|:....                .|:.|:||:|..|.||.|..||.:.|
  Fly    40 GHGLDASPAPGYGVPVIPKDPNL----------------RCEEITIPMCRGIGYNMTSFPNEMNH 88

Human   141 TNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLE---QALPPCRSLCERARQGCEALM 202
            ..|::||||||||:|||:::||.:|||||||||.|:|  ||   :.||.|||:|||||.||..:|
  Fly    89 ETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC--LEDYHKPLPVCRSVCERARSGCAPIM 151

Human   203 NKFGFQWPDTLKCEKFPVHG-AGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPG-- 264
            .::.|:||:.:.||..|:|| ...||:.|                 .|..:.|.||..||..|
  Fly   152 QQYSFEWPERMACEHLPLHGDPDNLCMEQ-----------------PSYTEAGSGGSSGGSGGSG 199

Human   265 -------------------GAGASE--------RGKFS---------------CPRALKVPS--- 284
                               |||.|.        ||:.|               |..:.:.|.
  Fly   200 SGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRSPLIFL 264

Human   285 ---------------------YLN---YHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGI 325
                                 |:|   ....|..:||.||:..      :|..:|..|:..||.:
  Fly   265 GKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAGVPNCGIPCKGP------FFSNDEKDFAGLWIAL 323

Human   326 WSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIA-GFLLEDRVVCNDKFAEDG 389
            ||.||..|||.|:.|:::|..||.||||||:|||.||..|||.|:: .||..:.:.|      ||
  Fly   324 WSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIAC------DG 382

Human   390 ARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAV 454
            .......|....||::|::.|||.|||||||||||.|||||||:|||:|||..:|||||||||.:
  Fly   383 LLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHLAAWLI 447

Human   455 PAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTI 519
            |.::::.:|.|..||||.:.|:|:||..|.|.|:.||||||||||.|||:||:||||||||||::
  Fly   448 PTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLFRIRSV 512

Human   520 MKHD-----GTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAI 579
            :|..     |.|.:||||||:|||:|||||||||||||.||.||.|:.:.|.:          |:
  Fly   513 IKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDWIK----------AL 567

Human   580 PCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRL 637
            .||..|..|     |...|.::|.|:||.|.|.||||||.||||||||.|||:|:.||
  Fly   568 ACPCAQVKG-----PGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRL 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FZD1	NP_003496.1	CRD_FZ1	112..238	CDD:143574	63/129 (49%)
		Frizzled	310..634	CDD:279827	177/329 (54%)
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	63/137 (46%)
		Frizzled	308..618	CDD:279827	178/330 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810