DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FZD1 and Corin

DIOPT Version :9

Sequence 1:	NP_003496.1	Gene:	FZD1 / 8321	HGNCID:	4038	Length:	647	Species:	Homo sapiens
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	211	Identity:	56/211 - (26%)
Similarity:	83/211 - (39%)	Gaps:	48/211 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   111 PDHGYCQPISIPLC--TDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMY 173
            |..|.|.||.:..|  ..|.||.|:.||.:||..|.:...::..:..||.|:|...:..|||:::
  Fly   774 PAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLF 838

Human   174 APVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTP 238
            .|.|......:|||::||....:.|....:.||...|:.|.|:.|....:.|.|||
  Fly   839 VPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVG--------- 894

Human   239 TPSLLPEF-----WTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDC-- 296
                |.|.     ..::|:..|                  |.|.:...:|.  .|...|..||
  Fly   895 ----LDEVREVMRAATHPKCDG------------------FQCDQNRCLPQ--EYVCDGHLDCMD 935

Human   297 ---GAPCE---PTKVY 306
               .|.||   |.::|
  Fly   936 QADEAKCERCGPDEIY 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FZD1	NP_003496.1	CRD_FZ1	112..238	CDD:143574	39/127 (31%)
FZD1	NP_003496.1	Frizzled	310..634	CDD:279827
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	36/115 (31%)
		LDLa	911..942	CDD:238060	9/50 (18%)
		LDLa	945..979	CDD:238060	2/7 (29%)
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810