Protein Alignment EOMES and Doc2

DIOPT Version :10

• Sequence 1: NP_001265111.1
• Gene: EOMES / 8320
• HGNCID: 3372
• Length: 705
• Species: Homo sapiens
• Sequence 2: NP_648282.1
• Gene: Doc2 / 39038
• FlyBaseID: FBgn0035956
• Length: 469
• Species: Drosophila melanogaster
• Alignment Length: 448
• Identity: 147/448 - (32%)
• Similarity: 205/448 - (45%)
• Gaps: 105/448 - (23%)

Human   260 VPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADP 324
            :||    ..:.|.|..||.:||:..|||||||.||||||.:..:::||...::|.|.:|:|....
  Fly    53 LPG----VEMTLQNDDLWKQFHQIGTEMIITKSGRRMFPSMRLSVSGLEDESNYCVLLEMVPIGD 113

Human   325 NHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIV 389
            ..::|.|.:||..|.|: .....:||:||:||.||:||..|.|.|.|:|||||   ..:|:..||
  Fly   114 CRYKFSGSQWVPAGGAE-PQSPQRMYLHPDSPATGAHWQAQPILFNKVKLTNN---TLDNSGHIV 174

Human   390 LQSLHKYQPRLHIVEVTEDGVEDLNE-P-SKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAK 452
            |.|:||||||||::...     ||.: | :..|.|.|:||:|:|||||||..||:||||:|||||
  Fly   175 LASMHKYQPRLHVIRTA-----DLAQIPWAPQQAFVFAETEFVAVTAYQNDRITKLKIDNNPFAK 234

Human   453 GFRD--------NYDSMYTASENDR---LTPSPTDSPRSHQIVPGG---RYGVQSFFPE--PFVN 501
            |||:        ...|..|..:.|:   |:.|.:.|........||   ..|..|....  |.:.
  Fly   235 GFRETGQSRCKRKMSSSPTGEDQDQSPSLSHSQSQSESDMSPTKGGGETAGGTSSIGDSDGPQIK 299

Human   502 TLPQARYYNG----------ERTVPQTNGLL--SPQQSEEVANPPQRWLVTPVQQPGTNKLDISS 554
            .|..    ||          :::||..:.|.  ||.......:.|.     |:|....:.:.:..
  Fly   300 RLRS----NGSACSLSSSLDDQSVPGASSLALGSPPPHLHSHSHPH-----PLQARSASSVFMQH 355

Human   555 YESEYTSSTLLP---------------YG--IKSLPLQTSHALGYYPDPTFPAMAGWGGRGSYQR 602
            :: :...|.|.|               ||  |::.|:        ||    ||.....|.|.:.
  Fly   356 FQ-QNMQSLLRPSLVDLACTYFGRPHEYGGAIQASPM--------YP----PAAMLQAGLGPHP- 406

Human   603 KMAAGLPWTSRTSPTVFSEDQLSKEKVKEE----IGS-------SWIETP---PSIKS 646
              ...||      |.|...|.:|.|...||    :||       |..|.|   ||.:|
  Fly   407 --GLNLP------PGVSGADLISDESGAEELELDVGSETSTLEQSTQEQPLEQPSTRS 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EOMES	NP_001265111.1	T-box_TBR2	266..456	CDD:410331	92/191 (48%)
		T-box_assoc	482..703	CDD:465042	46/213 (22%)
Doc2	NP_648282.1	T-box_Drosocross-like	56..238	CDD:410332	92/190 (48%)