Protein Alignment EOMES and H15

DIOPT Version :9

• Sequence 1: NP_001265111.1
• Gene: EOMES / 8320
• HGNCID: 3372
• Length: 705
• Species: Homo sapiens
• Sequence 2: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Alignment Length: 712
• Identity: 185/712 - (25%)
• Similarity: 254/712 - (35%)
• Gaps: 237/712 - (33%)

Human    29 SGGSAGHLPSAAPSPQKLDLDKASKKFSGSLSCEAVSGEPAAASAGAPAAMLSD----------- 82
            |...|...|...|||.:      ::.|...|..:.||   |||:|.|..|..|.
  Fly     4 SNQPANTKPQQTPSPSQ------TQNFKSKLQQQIVS---AAAAAAANIANGSSHHHHHQNHHHH 59

Human    83 -------------------TDAGDAFASAAAVAKPG------PPDGRKGSP-------------- 108
                               ||    |:.||.:|:.|      .|..|..||
  Fly    60 HPLNNHHNHNHNQHNISFATD----FSIAAIMARGGNAPSSREPSERSLSPASVERYSGQDADDD 120

Human   109 -------CGEEELPSAAAAAAAAAAAAAATA---------------------------------- 132
                   |.:.|:|||.|||||||..|||.|
  Fly   121 VDVDVVDCSDSEMPSATAAAAAAATTAAAAAAALQAQQQARQALRVAQQQQQQQQQQRQQTHHHA 185

Human   133 ------RYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPHGPVYPAPNGARYPYGSML 191
                  |...:..||......:.|...:...:........||.||...|..|.|
  Fly   186 TTGKQQRQHHNHHSSNTNNSSNSGNSNTNSKSSSQRGRSAAAVGAAATPSPPPP----------- 239

Human   192 PPGGFPAAVCPPGRAQFGPGAGAGSGAGGSSGGGGGPGTYQYSQGAPLYGPYPGAAAAGSCGGLG 256
            ||...|..:     .:..|                        :.:|...|.|....:.:|..|
  Fly   240 PPSQSPEEL-----ERLSP------------------------EESPAQQPTPKIVGSCNCDDL- 274

Human   257 GLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNING----LNPTAHYNVFV 317
               .|     ...:|..:.||.|||...|||||||.||||||.:..:.:|    :.|...|.|.:
  Fly   275 ---TP-----VQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLL 331

Human   318 EVVLADPNHWR--FQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGA 380
            :||..|...:|  :....|:..|||| ....:::|.||:.|.:.....:|.:||.|:|||||:
  Fly   332 DVVPLDSRRYRYAYHRSSWLVAGKAD-PPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNE-- 393

Human   381 NNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQ-----TFTFSETQFIAVTAYQNTDI 440
             .:.:..:||.|:|:||||:|:|.::. |......|.:.|     ||.|.||.|.|||||||..|
  Fly   394 -MDKSGQVVLNSMHRYQPRIHLVRLSH-GQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLI 456

Human   441 TQLKIDHNPFAKGFRDNYDSMYTASENDRLTPSPTDSPRSHQIVPGGRYGVQSFFPEPFVNTL-P 504
            |:||||.|||||||||:    ...|:.||   .|.|:....|.:   |.....|||:|.::.| |
  Fly   457 TKLKIDSNPFAKGFRDS----SRLSDFDR---DPMDAFFFDQHM---RTAPLRFFPDPLMSQLTP 511

Human   505 Q------------ARYY---NGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPGTNKLDISS 554
            |            ||.:   .|..  |.|..||........|.||      |...|..:...:..
  Fly   512 QEADAASMALLEKARQHLQMFGRS--PYTEMLLPHLYQRSAAPPP------PPPAPHLSAFQLGM 568

Human   555 YESEYTSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGSYQRKMAAGLPWTSRTSP 616
            ::.::...|                            ||:....:.|..:|......:||.|
  Fly   569 WQQQWPQLT----------------------------AGFLASANQQAALALAAAGANRTPP 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EOMES	NP_001265111.1	TBOX	267..460	CDD:238106	86/203 (42%)
		T-box_assoc	482..703	CDD:292794	29/151 (19%)
H15	NP_608926.2	TBOX	276..475	CDD:238106	87/212 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141534
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740