Protein Alignment EOMES and bi

DIOPT Version :9

• Sequence 1: NP_001265111.1
• Gene: EOMES / 8320
• HGNCID: 3372
• Length: 705
• Species: Homo sapiens
• Sequence 2: NP_001259238.1
• Gene: bi / 31379
• FlyBaseID: FBgn0000179
• Length: 1023
• Species: Drosophila melanogaster
• Alignment Length: 643
• Identity: 185/643 - (28%)
• Similarity: 248/643 - (38%)
• Gaps: 209/643 - (32%)

Human    65 SGEPAAASAGAPAAMLSDTDAGDAFA--SAAAVAKPGPPDGRKGSPCGEEELPSAAAAAAAAAAA 127
            :|.|.....|.|.....:.::..:.:  ||:|.|.|      ...|......||..|||..|.|.
  Fly   159 AGTPPPTIVGLPPIPPPNNNSSSSSSNNSASAAAHP------SHHPTAAHHSPSTGAAAPPAGAT 217

Human   128 AAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPH-------GPVYPAPNGARY 185
            .                 |..|.|                    ||       ...:|||.
  Fly   218 G-----------------LPPPTP--------------------PHHLQQQQQQQQHPAPP---- 241

Human   186 PYGSMLPPGGFPAAVCPPGRAQFGPGAGAGSGAGGSSG---GGGGPGTYQYSQGAPLYGPYPGAA 247
                  ||..||||..         .|.|||.||...|   |||    .::....|  |.:|.|.
  Fly   242 ------PPPYFPAAAL---------AALAGSPAGPHPGLYPGGG----LRFPPHHP--GAHPHAH 285

Human   248 AAGSCGGLGGLGVPGSGFRAHVYLCNRP-----------------------LWLKFHRHQTEMII 289
            ..||........|..|.....::...||                       ||.|||:..|||:|
  Fly   286 HLGSAYTTAEDVVLASAVAHQLHPAMRPLRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVI 350

Human   290 TKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPE 354
            ||.||:|||.:.|.::||:..|.|.:.:::|.||...::|...:|:..||||..|. .:||:||:
  Fly   351 TKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYKFHNSRWMVAGKADPEMP-KRMYIHPD 414

Human   355 SPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKT 419
            ||.||..||::.:||.|||||||....:......:|.|:||||||.|:|...    :.|..|..|
  Fly   415 SPTTGEQWMQKVVSFHKLKLTNNISDKHGFVSTTILNSMHKYQPRFHLVRAN----DILKLPYST 475

Human   420 -QTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRD-------NYDSMYT--ASENDRLTPSP 474
             :|:.|.||:|||||||||..|||||||:|||||||||       ...::.:  .|::|:|.|:.
  Fly   476 FRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGFRDTGAGKREKKQALMSNRGSDSDKLNPTH 540

Human   475 TDSPRSH-QIVPGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSE-----EVANP 533
            ..|.|:. .:...||        .|.::  |.|             .||..||.:     :|..|
  Fly   541 VSSSRAPLHLGHAGR--------PPHLH--PHA-------------ALLDNQQDDDDKLLDVVGP 582

Human   534 PQRWLVTPVQQPGTNKLDISSYESEYTSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGW---- 594
            ||                          |.|||.   |..||..||..:     ..|:|.|
  Fly   583 PQ--------------------------SPLLPL---SHSLQQMHAHQH-----SAALAAWFNHL 613

Human   595 --GGRGSYQRKMAAGLPWTSRTSPTVFSEDQL--------------SKEKVKEEIGSS 636
              .|.|:.:...||        :....:||.|              |.....|.:|.|
  Fly   614 AGAGAGASEHAAAA--------AANASAEDALRRRLQADADVERDGSDSSCSESVGGS 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EOMES	NP_001265111.1	TBOX	267..460	CDD:238106	94/223 (42%)
		T-box_assoc	482..703	CDD:292794	36/180 (20%)
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	15/63 (24%)
		T-box	330..513	CDD:279278	90/187 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810