DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDC45 and Cdc45

DIOPT Version :9

Sequence 1:	NP_001171481.1	Gene:	CDC45 / 8318	HGNCID:	1739	Length:	598	Species:	Homo sapiens
Sequence 2:	NP_569880.1	Gene:	Cdc45 / 31052	FlyBaseID:	FBgn0026143	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	617	Identity:	234/617 - (37%)
Similarity:	371/617 - (60%)	Gaps:	61/617 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFVSDFRKEFYEVVQSQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAFLEH 65
            |||.|.|.:||..:..:|:|:.|..|:||:||.:||||||:.||:.||:||:.|...|:.|:.||
  Fly     1 MFVQDLRNDFYRQLVGKRILIVVNYDIDAICASRILQALFKYDHMLYTVVPIMGVTGLKRAYGEH 65

Human    66 KEQFHYFILINCGANVDLLDILQPDEDTIFFVCDTHRPVNVVNVYNDTQIKLLIKQDDDLE--VP 128
            :....|.:|:|||..||::::|||.:|..||:||:|||::|.|:|:|.|:.:|  .|..||  :|
  Fly    66 QGDVKYVVLVNCGGCVDIVELLQPSDDVTFFICDSHRPLDVCNIYSDRQVCIL--GDASLEENIP 128

Human   129 AYEDIFRD---EEEDEEHSG-------------NDSDGSEP-SEKRTRLEEEIVEQTMRRRQRRE 176
            |:|.||.|   |:|||:.|.             :|.:...| |.|.:|||.. .::.:::|.||:
  Fly   129 AFETIFYDSEGEDEDEDESSDTEQQHDDSGAGESDQEDQAPRSRKLSRLERH-EQRILKQRARRQ 192

Human   177 WEARSGSGSEPVAAALEKSSRLFAGPMSDRTAPRSPRRDILFDYEQYEYHGTSSAMVMFELAWML 241
            ||                                |.|..|:|:|.|:.|:|.|:|:::|||||.|
  Fly   193 WE--------------------------------SERDRIMFEYTQFSYYGRSAALMVFELAWKL 225

Human   242 SKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRHNHRNEDEENTLSVDCTRISFEY 306
            |||..|:|||||||:|:|.:..||....|..::..:|.||||..::..| :||:|  .::|:||.
  Fly   226 SKDNMDLLWWAIVGITEQLLLGKIESGAYTLELEQIQSHVSRLTNKTND-QNTMS--ASKITFEN 287

Human   307 DLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDISLKEN 371
            ||.||||:||.:.:|:..:.|::.:.|||::.|:|||.|.|.:|||||...:|.:.|||:.|::.
  Fly   288 DLHLVLYRHWPVTESMRYSRYSSCQLKLWTLRGEKRLHELLLEMGLPLVHARQTYGAMDLVLRKE 352

Human   372 LREMIEESANKFGMKDMRVQTFSIHFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSL 436
            ...|:|..|.|:.:.|:...||::.:|::.::.|:|.|:|.:::|||.:|..:..|.|::|.|:|
  Fly   353 FFSMVERLAEKYDIADIVYGTFTLSYGYRSRYAAADYVYALLAIMESVKKHKTPEDCFLEASDAL 417

Human   437 SRSNLDKLYHGLELAKKQLRATQQTIASCLCTNLVISQGPFLYCSLMEGTPDVMLFSRPASLSLL 501
            ||.:...|..|::.||....|..:.:.|.|....|.|.|.|.|..|.|   :...||.|.:|.||
  Fly   418 SRQHKQLLSAGIDQAKLLHAAVFRQVQSSLEARQVHSAGSFFYYVLQE---EHAFFSYPYALGLL 479

Human   502 SKHLLKSFVCSTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTS 566
            ::.||:..|.:::.|:...|||:.:.||:...|...:|||.|..:.|.| ||||:|||:||:.:.
  Fly   480 ARFLLRGHVATSRARQASDLPLIASCPLNASEGMCLLVGIVPVREDSPR-NFFGKAFEQAAQKSG 543

Human   567 SRMLHNHFDLSVIELKAEDRSKFLDALISLLS 598
            ..:|.:.|:.:|::|:..|.::|||:|..||:
  Fly   544 VALLQDFFEPAVVQLRQSDLTRFLDSLTVLLA 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDC45	NP_001171481.1	CDC45	19..593	CDD:280821	223/592 (38%)
Cdc45	NP_569880.1	CDC45	19..571	CDD:367156	223/593 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151429
Domainoid	1	1.000	417	1.000	Domainoid score	I649
eggNOG	1	0.900	-	-		E1_KOG2475
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2616
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1694
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53772
OrthoDB	1	1.010	-	-		D1309031at2759
OrthoFinder	1	1.000	-	-		FOG0004931
OrthoInspector	1	1.000	-	-		oto88439
orthoMCL	1	0.900	-	-		OOG6_102930
Panther	1	1.100	-	-	LDO	PTHR10507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4027
SonicParanoid	1	1.000	-	-		X4597
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800