Protein Alignment CDC45 and Cdc45

DIOPT Version :10

• Sequence 1: NP_001171481.1
• Gene: CDC45 / 8318
• HGNCID: 1739
• Length: 598
• Species: Homo sapiens
• Sequence 2: NP_569880.1
• Gene: Cdc45 / 31052
• FlyBaseID: FBgn0026143
• Length: 575
• Species: Drosophila melanogaster
• Alignment Length: 617
• Identity: 234/617 - (37%)
• Similarity: 371/617 - (60%)
• Gaps: 61/617 - (9%)

Human     1 MFVSDFRKEFYEVVQSQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAFLEH 65
            |||.|.|.:||..:..:|:|:.|..|:||:||.:||||||:.||:.||:||:.|...|:.|:.||
  Fly     1 MFVQDLRNDFYRQLVGKRILIVVNYDIDAICASRILQALFKYDHMLYTVVPIMGVTGLKRAYGEH 65

Human    66 KEQFHYFILINCGANVDLLDILQPDEDTIFFVCDTHRPVNVVNVYNDTQIKLLIKQDDDLE--VP 128
            :....|.:|:|||..||::::|||.:|..||:||:|||::|.|:|:|.|:.:|  .|..||  :|
  Fly    66 QGDVKYVVLVNCGGCVDIVELLQPSDDVTFFICDSHRPLDVCNIYSDRQVCIL--GDASLEENIP 128

Human   129 AYEDIFRD---EEEDEEHSG-------------NDSDGSEP-SEKRTRLEEEIVEQTMRRRQRRE 176
            |:|.||.|   |:|||:.|.             :|.:...| |.|.:|||.. .::.:::|.||:
  Fly   129 AFETIFYDSEGEDEDEDESSDTEQQHDDSGAGESDQEDQAPRSRKLSRLERH-EQRILKQRARRQ 192

Human   177 WEARSGSGSEPVAAALEKSSRLFAGPMSDRTAPRSPRRDILFDYEQYEYHGTSSAMVMFELAWML 241
            ||                                |.|..|:|:|.|:.|:|.|:|:::|||||.|
  Fly   193 WE--------------------------------SERDRIMFEYTQFSYYGRSAALMVFELAWKL 225

Human   242 SKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRHNHRNEDEENTLSVDCTRISFEY 306
            |||..|:|||||||:|:|.:..||....|..::..:|.||||..::..| :||:|  .::|:||.
  Fly   226 SKDNMDLLWWAIVGITEQLLLGKIESGAYTLELEQIQSHVSRLTNKTND-QNTMS--ASKITFEN 287

Human   307 DLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDISLKEN 371
            ||.||||:||.:.:|:..:.|::.:.|||::.|:|||.|.|.:|||||...:|.:.|||:.|::.
  Fly   288 DLHLVLYRHWPVTESMRYSRYSSCQLKLWTLRGEKRLHELLLEMGLPLVHARQTYGAMDLVLRKE 352

Human   372 LREMIEESANKFGMKDMRVQTFSIHFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSL 436
            ...|:|..|.|:.:.|:...||::.:|::.::.|:|.|:|.:::|||.:|..:..|.|::|.|:|
  Fly   353 FFSMVERLAEKYDIADIVYGTFTLSYGYRSRYAAADYVYALLAIMESVKKHKTPEDCFLEASDAL 417

Human   437 SRSNLDKLYHGLELAKKQLRATQQTIASCLCTNLVISQGPFLYCSLMEGTPDVMLFSRPASLSLL 501
            ||.:...|..|::.||....|..:.:.|.|....|.|.|.|.|..|.|   :...||.|.:|.||
  Fly   418 SRQHKQLLSAGIDQAKLLHAAVFRQVQSSLEARQVHSAGSFFYYVLQE---EHAFFSYPYALGLL 479

Human   502 SKHLLKSFVCSTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTS 566
            ::.||:..|.:::.|:...|||:.:.||:...|...:|||.|..:.|.| ||||:|||:||:.:.
  Fly   480 ARFLLRGHVATSRARQASDLPLIASCPLNASEGMCLLVGIVPVREDSPR-NFFGKAFEQAAQKSG 543

Human   567 SRMLHNHFDLSVIELKAEDRSKFLDALISLLS 598
            ..:|.:.|:.:|::|:..|.::|||:|..||:
  Fly   544 VALLQDFFEPAVVQLRQSDLTRFLDSLTVLLA 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDC45	NP_001171481.1	CDC45	19..593	CDD:460663	223/592 (38%)
Cdc45	NP_569880.1	CDC45	19..570	CDD:460663	223/592 (38%)