DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDC7 and Cdc7

DIOPT Version :9

Sequence 1:	NP_001127891.1	Gene:	CDC7 / 8317	HGNCID:	1745	Length:	574	Species:	Homo sapiens
Sequence 2:	NP_001101822.1	Gene:	Cdc7 / 360908	RGDID:	1308351	Length:	565	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	458/569 - (80%)
Similarity:	493/569 - (86%)	Gaps:	10/569 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     9 MDEPMAFSPQR--DRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSS 71
            |:|||||||.|  ||..|:.||||.||:.||:|:|:|||:|.||||||.:||||:||||||||||
  Rat     1 MEEPMAFSPLRGCDRCPADDSLKKYEQSVKLSGIKRDIEELCEAVPQLVSVFKIKDKIGEGTFSS 65

Human    72 VYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPY 136
            |||||||||.|.|||||||||||||||:|||||||||||||||||||||||||||||||||||||
  Rat    66 VYLATAQLQEGREEKIALKHLIPTSHPVRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPY 130

Human   137 LEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQ 201
            ||||||||||||||||||||||.|||.||||||||||||||||||||||||||||||||||||||
  Rat   131 LEHESFLDILNSLSFQEVREYMFNLFVALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQ 195

Human   202 GTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQ 266
            ||.|||||||||||||||||.||:||.|.:.|:|.|||.|.||.:||..|||.||||.|.||||.
  Rat   196 GTRDTKIELLKFVQSEAQQEDCSRNKCHGVIGHKGPLSRPAPKNVDQHITTKTSVKRSYANAQIH 260

Human   267 IKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTK 331
            ||||||||||||||||||||||||||||||||||||||.||:|||||||::||||||||.|:|||
  Rat   261 IKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAEKLIKQSKTVDIMSRKLATKKMAVSTK 325

Human   332 VMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAID 396
            .:||: ||.:|.||||:||||||.||:|||:|||||||||||||||||||||||||||:||||||
  Rat   326 AVNSS-MRDSARSCPAALTCDCYGTDRVCSVCLSRRQQVAPRAGTPGFRAPEVLTKCPDQTTAID 389

Human   397 MWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKL 461
            |||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||.|
  Rat   390 MWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGKSILCSKEVPAQDLRTL 454

Human   462 CERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTP--PGQYSGNS-FKKGDSNSCEH 523
            ||||||.||:.||...|..|:..|.||.||.|||||.   ..|  |.|:|.:| :|:|......|
  Rat   455 CERLRGPDSANPKSAVDPPGNTGHHPAASESTDHKAP---HAPASPAQHSEDSLYKRGSGGGRRH 516

Human   524 CFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM 572
            ..|. ..|.|||:.|||:||||||||||||||||||||.||:||||||:
  Rat   517 PRDR-TANPEGWDSVPDDAYDLLDKLLDLNPASRITAEAALVHPFFKDV 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDC7	NP_001127891.1	STKc_Cdc7	56..438	CDD:270921	337/381 (88%)
		PKc_like	<293..>419	CDD:328722	107/125 (86%)
		PKc_like	<358..571	CDD:328722	163/215 (76%)
Cdc7	NP_001101822.1	STKc_Cdc7	52..461	CDD:270921	364/409 (89%)
Cdc7	NP_001101822.1	PKc_like	<372..562	CDD:304357	143/193 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83692370
Domainoid	1	1.000	285	1.000	Domainoid score	I16413
eggNOG	1	0.900	-	-		E1_KOG1167
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31166
Inparanoid	1	1.050	888	1.000	Inparanoid score	I6559
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG60149
OrthoDB	1	1.010	-	-		D1361975at2759
OrthoFinder	1	1.000	-	-		FOG0003769
OrthoInspector	1	1.000	-	-		oto135436
orthoMCL	1	0.900	-	-		OOG6_103228
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2628
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310