Protein Alignment CDC7 and cdc-7

DIOPT Version :9

• Sequence 1: NP_001127891.1
• Gene: CDC7 / 8317
• HGNCID: 1745
• Length: 574
• Species: Homo sapiens
• Sequence 2: NP_491705.1
• Gene: cdc-7 / 172260
• WormBaseID: WBGene00016421
• Length: 411
• Species: Caenorhabditis elegans
• Alignment Length: 546
• Identity: 123/546 - (22%)
• Similarity: 201/546 - (36%)
• Gaps: 181/546 - (33%)

Human    40 VKKDIEKLYEA-VPQLSNV-----FKIEDK-IGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSH 97
            :|....|::|. .|.||:.     :::::. ||||:|.:|..||.:.   .:||.|:|.:.....
 Worm     3 IKSSRLKIWEENCPVLSDAKFQRKYQLQENIIGEGSFGTVISATCRT---TQEKRAIKAIRRIEK 64

Human    98 PIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDIL----NSLSFQEVREYM 158
            ...::.||:.|:..||..|::.:...|..|..|.|.:.:..|.:..::|    ..|||  ...|.
 Worm    65 MSMLSIELELLSELGGHFNIVKLFEFFHFNGSVAIVLEHFPHCTATELLFHSKRDLSF--ALSYF 127

Human   159 LNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERC 223
            .||..|:..:|..|.||||:|.|||||:.:.:::.|||||||              ..:..:..|
 Worm   128 RNLLYAVAYLHHNGYVHRDIKLSNFLYSPQTQRFRLVDFGLA--------------TVDRSKNEC 178

Human   224 SQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFG 288
            |  :||
 Worm   179 S--RSH----------------------------------------------------------- 182

Human   289 ERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDC 353
                           ||..|::.                               ..|     |.|
 Worm   183 ---------------AVAAMERD-------------------------------PEC-----CSC 196

Human   354 YATDKVCSICLSR-RQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKA 417
            ..|...|..|..: :::.....||||.||||:|........:||::|.|::.|||:|.::||:..
 Worm   197 KGTSSPCMFCRGKPKRENYNVVGTPGVRAPELLFGIGLCHPSIDIFSCGIVLLSLVSVKHPFFMP 261

Human   418 SDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLR-GMDSSTPKLTSDIQG 481
            .|:...:..:..:.||....:.|.:.|..:..|:::|..|...|...|| |.|        .::.
 Worm   262 KDETENIMHLAFLLGSETIEKMAHSEGLRVTLSEKLPPADYYHLILCLRFGFD--------HVRR 318

Human   482 H--ASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCF--DEYNTNL--EGWN--EV 538
            |  :|.||           |.:          ..|:..:||...||  ..|.|::  .|.|  |:
 Worm   319 HCSSSRQP-----------CTI----------CQKRSFNNSMGVCFCRKNYETDMFSTGGNETEL 362

Human   539 PDEAYDLLDKLLDLNPASRITAEEAL 564
            .....|||.:.|:.:...|..|::.|
 Worm   363 MTIYVDLLYRTLEADRFKRYNADQLL 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDC7	NP_001127891.1	STKc_Cdc7	56..438	CDD:270921	85/392 (22%)
		PKc_like	<293..>419	CDD:328722	28/126 (22%)
		PKc_like	<358..571	CDD:328722	56/217 (26%)
cdc-7	NP_491705.1	PKc_like	34..277	CDD:389743	83/373 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161470922
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1167
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1361975at2759
OrthoFinder	1	1.000	-	-		FOG0003769
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103228
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.700