Protein Alignment AXIN2 and axin2

DIOPT Version :10

• Sequence 1: NP_004646.3
• Gene: AXIN2 / 8313
• HGNCID: 904
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_571636.1
• Gene: axin2 / 58080
• ZFINID: ZDB-GENE-000403-2
• Length: 812
• Species: Danio rerio
• Alignment Length: 858
• Identity: 544/858 - (63%)
• Similarity: 632/858 - (73%)
• Gaps: 74/858 - (8%)

Human    10 LPDPS-SSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPM-PVS--------SNTRRNEDGLGE 64
            |.||. ||||||.||||||||||||....|  .|..:.:|. ||.        |..||:||||||
Zfish     5 LTDPMVSSFREDDPRPPVPGEEGETTCHHP--SKLAMMRPKDPVKTIMADLRCSTARRDEDGLGE 67

Human    65 PEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLR 129
            |||.|||||||.|||||||.||||||||.|||.:||||||||||||||||||||||:||||||.|
Zfish    68 PEGSASPDSPLARWTKSLHFLLGDQDGAQLFRAYLEREKCVDTLDFWFACNGFRQMDLKDTKTHR 132

Human   130 VAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSD 194
            ||||||||||||||||:|||||||||:|||.||:|||||.||||||.|||:.|||||||||||||
Zfish   133 VAKAIYKRYIENNSIVAKQLKPATKTFIRDNIKRQQIDSAMFDQAQMEIQTAMEENAYQMFLTSD 197

Human   195 IYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFKCKLSPTVVGLSSKTLRATA 259
            |||||||:|.||.::::..|||.||:||||||||||||||:|.|||.|...||||||:|||| :.
Zfish   198 IYLEYVRTGCENPSHVNPNGLGGLKLVCGYLPTLNEEEEWSCNDFKAKALATVVGLSAKTLR-SP 261

Human   260 SVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPP 324
            .:|:.|.::.||||::||||.||....|||.|||||||||||:||||||||||||||||||.|||
Zfish   262 PLRAVEALEKGYRSYRRSDPGNPNRFTSGYSFAPATSANDSEVSSDALTDDSMSMTDSSVDAIPP 326

Human   325 YRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRH 389
            |::||||||||||.|:::.|||||||.||||.|.||||||||||.|||:||:|||:||.|.|:..
Zfish   327 YKLGSKKQLQREMQRNMRMNGQVSLPPFPRTRRPPKEMTPVEPAAFAAQLIARLERLKREQETMS 391

Human   390 SLEERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQS 454
            |||||||||:|:|||:.||::.:|     ..|.|.|||.|:.|||||.|||:|||||||||||||
Zfish   392 SLEERLQQIQEEEERDESEMSSSS-----ASHSLPLLPPGTCEEDPQAILDEHLSRVLKTPGCQS 451

Human   455 PGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYI 519
            ||:.|:|||||||:...         ||.|| |...:.|......:..|.|:::|:|||:|||||
Zfish   452 PGLLRHSPRSRSPEQRP---------LPRGG-LSTRSQSSSMNGYVPAKTFISRQSTKHIHHHYI 506

Human   520 HHHAVPKTKEEIEAEATQRVHCFCPGGSEYYC----YSKCKSHSKAPETMPSEQFGGSRGSTLPK 580
            ||||.||:||:||.||||||.|.|.|.||  |    |.:.:|..:.....|:|...| ..|||.|
Zfish   507 HHHAGPKSKEQIEVEATQRVQCLCHGTSE--CCTAPYIRSRSLGRDQCASPAEVALG-HSSTLSK 568

Human   581 R--------NGKGTEPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSA 637
            |        |.:|.|..|               ||||.:..||||:||||:|||:||:|.||||.
Zfish   569 RLCKSGEEVNMEGLENSL---------------LQLPADSTDRSQNVWQWILESDRQTKHKPHST 618

Human   638 QSTKKAYPLESARSSPGERASRHHLW--GGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEA 700
            |:.||::.||..|:         |.|  ||:|||.|....||.|.||||||||.|||||||||||
Zfish   619 QNVKKSHSLEPTRT---------HTWGGGGSSGHLRAHQPAHPFVQDPAMPPLPPPNTLAQLEEA 674

Human   701 CRRLAEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELV 765
            .|||.|||||.|||...:|.|||::|...||.|::.|     ..::.|:|||::|.|:...||.|
Zfish   675 RRRLEEVSKPSKQRHSTSSLQRDKSHPVPVQNGSSAF-----PMDERKDPKKMSGCHSSLGSETV 734

Human   766 VTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPM 830
            |||||||||||||||:|..|||||||||||.|||||||:||:|||||.|||||||:|:|.|||||
Zfish   735 VTYFFCGEEIPYRRMMKTHSLTLGHFKEQLRKKGNYRYFFKRASDEFECGAVFEEVWDDCTVLPM 799

Human   831 YEGRILGKVERID 843
            |||:|||||:|:|
Zfish   800 YEGKILGKVDRMD 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AXIN2	NP_004646.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		43/74 (58%)
		AXIN1_TNKS_BD	10..75	CDD:465215	43/74 (58%)
		Tankyrase-binding motif	21..30		7/8 (88%)
		RGS_Axin	82..198	CDD:188662	101/115 (88%)
		Interaction with GSK3B. /evidence=ECO:0000250	327..413		60/85 (71%)
		Interaction with SIAH1 and SIAH2. /evidence=ECO:0000269|PubMed:28546513	334..393		41/58 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..435		18/38 (47%)
		Interaction with beta-catenin. /evidence=ECO:0000250	413..476		38/62 (61%)
		Axin_b-cat_bind	433..468	CDD:462616	29/34 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..494		23/46 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..674		48/122 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..748		9/29 (31%)
		DAX	761..843	CDD:197474	67/81 (83%)
axin2	NP_571636.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		23/39 (59%)
		Axin_TNKS_binding	7..76	CDD:211424	40/70 (57%)
		RGS_Axin	85..201	CDD:188662	101/115 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	275..326		40/50 (80%)
		Interaction with GSK3B. /evidence=ECO:0000250	329..415		60/85 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..430		23/46 (50%)
		Interaction with beta-catenin. /evidence=ECO:0000250	415..467		38/56 (68%)
		Axin_b-cat_bind	430..465	CDD:462616	29/34 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..484		22/47 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	609..726		68/130 (52%)
		DIX	732..808	CDD:459936	63/75 (84%)