Protein Alignment AXIN2 and Axin2

DIOPT Version :10

• Sequence 1: NP_004646.3
• Gene: AXIN2 / 8313
• HGNCID: 904
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_077331.1
• Gene: Axin2 / 29134
• RGDID: 69259
• Length: 838
• Species: Rattus norvegicus
• Alignment Length: 843
• Identity: 760/843 - (90%)
• Similarity: 789/843 - (93%)
• Gaps: 5/843 - (0%)

Human     1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNEDGLGEP 65
            ||||:|||.|||||||||||||||||||||||||||||.|||.|.|||||||||.||||||||||
  Rat     1 MSSAVLVTLLPDPSSSFREDAPRPPVPGEEGETPPCQPSVGKVQSTKPMPVSSNARRNEDGLGEP 65

Human    66 EGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRV 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 EGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRV 130

Human   131 AKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDI 195
            |||||||||||||:||||||||||||||||||||||.|:||||||||||:||||||||:||||||
  Rat   131 AKAIYKRYIENNSVVSKQLKPATKTYIRDGIKKQQIGSVMFDQAQTEIQAVMEENAYQVFLTSDI 195

Human   196 YLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFKCKLSPTVVGLSSKTLRATAS 260
            |||||||||||||||||||||||||:|||||||||||||||||.|||||||||||||||||||||
  Rat   196 YLEYVRSGGENTAYMSNGGLGSLKVLCGYLPTLNEEEEWTCADLKCKLSPTVVGLSSKTLRATAS 260

Human   261 VRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPPY 325
            ||||||.::|:||||||:||||||:||||||||||||||||:|||||||||||||||||||||||
  Rat   261 VRSTETAENGFRSFKRSEPVNPYHVGSGYVFAPATSANDSELSSDALTDDSMSMTDSSVDGIPPY 325

Human   326 RVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHS 390
            |:|||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||
  Rat   326 RMGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPAAFAAELISRLEKLKLELESRHS 390

Human   391 LEERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSP 455
            |||||||||||||:||||..|:||:|||.||||:|||||||||||||||||||||||||||||||
  Rat   391 LEERLQQIREDEEKEGSEQALSSRDGAPVQHPLALLPSGSYEEDPQTILDDHLSRVLKTPGCQSP 455

Human   456 GVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIH 520
            |||||||||||||||||||.|.|:|||.||||||.|    ||||||||.|:||||||||||||||
  Rat   456 GVGRYSPRSRSPDHHHHHHQQCHALLPTGGKLPPEA----ACPLLGGKSFLTKQTTKHVHHHYIH 516

Human   521 HHAVPKTKEEIEAEATQRVHCFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKG 585
            |||||||||||||||||||.|.||||::||||||||||||.||.:|.|||.||||.||||||.||
  Rat   517 HHAVPKTKEEIEAEATQRVRCLCPGGTDYYCYSKCKSHSKPPEPLPGEQFCGSRGGTLPKRNTKG 581

Human   586 TEPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESAR 650
            |||||||||||||....|||.|||.|||||||||||||||||||||.||||.||.:|:|||||||
  Rat   582 TEPGLALPAREGGMSSAAGAPQLPGEEGDRSQDVWQWMLESERQSKSKPHSTQSIRKSYPLESAR 646

Human   651 SSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRC 715
            :.||||.|||||.|. |||||:..|||.||||||||||||||||||||||||||||||||.||||
  Rat   647 APPGERVSRHHLLGA-SGHPRSAARAHPFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPQKQRC 710

Human   716 CVASQQRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM 780
            |||||||||||.||.|.|.|.|||||||.|||||||:||.|||||||||:|||||||||||||||
  Rat   711 CVASQQRDRNHPATGQAGPTSFSNPSLASEDHKEPKRLASVHALQASELIVTYFFCGEEIPYRRM 775

Human   781 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVERID 843
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||
  Rat   776 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWDDETVLPMYEGRILGKVERID 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AXIN2	NP_004646.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		67/73 (92%)
		AXIN1_TNKS_BD	10..75	CDD:465215	60/64 (94%)
		Tankyrase-binding motif	21..30		8/8 (100%)
		RGS_Axin	82..198	CDD:188662	110/115 (96%)
		Interaction with GSK3B. /evidence=ECO:0000250	327..413		80/85 (94%)
		Interaction with SIAH1 and SIAH2. /evidence=ECO:0000269|PubMed:28546513	334..393		57/58 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..435		31/38 (82%)
		Interaction with beta-catenin. /evidence=ECO:0000250	413..476		59/62 (95%)
		Axin_b-cat_bind	433..468	CDD:462616	34/34 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..494		40/46 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..674		87/112 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..748		23/29 (79%)
		DAX	761..843	CDD:197474	79/81 (98%)
Axin2	NP_077331.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		67/73 (92%)
		AXIN1_TNKS_BD	10..75	CDD:465215	60/64 (94%)
		Tankyrase-binding motif	21..30		8/8 (100%)
		RGS_Axin	82..198	CDD:188662	110/115 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..333		30/32 (94%)
		Interaction with GSK3B. /evidence=ECO:0000250	327..413		80/85 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..435		29/36 (81%)
		Interaction with beta-catenin. /evidence=ECO:0000250	413..476		59/62 (95%)
		Axin_b-cat_bind	433..468	CDD:462616	34/34 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..483		29/32 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	568..682		91/114 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	712..744		25/31 (81%)
		DAX	756..838	CDD:197474	79/81 (98%)