Protein Alignment AXIN2 and rgs1

DIOPT Version :10

• Sequence 1: NP_004646.3
• Gene: AXIN2 / 8313
• HGNCID: 904
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_593029.1
• Gene: rgs1 / 2541764
• PomBaseID: SPAC22F3.12C
• Length: 481
• Species: Schizosaccharomyces pombe
• Alignment Length: 110
• Identity: 25/110 - (22%)
• Similarity: 40/110 - (36%)
• Gaps: 22/110 - (20%)

Human   725 NHSATVQTGATPFSNPSLAPEDHK-----EPKKLAGVHALQASE--LVVTYFFCGEEIPYRRMLK 782
            ||||.|....:.||:.....:|..     ..:.|..||.:..|:  |:|..:......|
pombe   183 NHSAPVIVSISRFSSTDQILKDSSFCEMLLVRMLGSVHEIGKSKNPLLVPVYSVSSPSP------ 241

Human   783 AQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETV 827
                     |:.|||...|:.:....::...|..:..:..|.|||
pombe   242 ---------KDSLSKVTKYQMFGIDIAEWLMCNTMLLDWSEMETV 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AXIN2	NP_004646.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75
		AXIN1_TNKS_BD	10..75	CDD:465215
		Tankyrase-binding motif	21..30
		RGS_Axin	82..198	CDD:188662
		Interaction with GSK3B. /evidence=ECO:0000250	327..413
		Interaction with SIAH1 and SIAH2. /evidence=ECO:0000269|PubMed:28546513	334..393
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..435
		Interaction with beta-catenin. /evidence=ECO:0000250	413..476
		Axin_b-cat_bind	433..468	CDD:462616
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..494
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..674
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..748		8/22 (36%)
		DAX	761..843	CDD:197474	14/69 (20%)
rgs1	NP_593029.1	DEP	59..156	CDD:214489
		DEP_RGS7-like	224..309	CDD:239897	14/69 (20%)
		RGS_FLBA	344..480	CDD:188663