| Sequence 1: | NP_004646.3 | Gene: | AXIN2 / 8313 | HGNCID: | 904 | Length: | 843 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001040672.1 | Gene: | axl-1 / 186869 | WormBaseID: | WBGene00010497 | Length: | 400 | Species: | Caenorhabditis elegans |
| Alignment Length: | 230 | Identity: | 49/230 - (21%) |
|---|---|---|---|
| Similarity: | 90/230 - (39%) | Gaps: | 61/230 - (26%) |
- Green bases have known domain annotations that are detailed below.
|
Human 635 HSAQSTKKAYPLESARSSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPP-LTPPNTLAQLE 698
Human 699 EACRRLAEVSKPPKQRCCVASQQRDR---NHSATVQTGATPF--------SNPSLAPEDHK---- 748
Human 749 --------EPKKLAGVHALQASELVVTYFFCGEEIPYRRMLK---AQSLTLGHFKE--QLSKKGN 800
Human 801 YRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRI 835 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| AXIN2 | NP_004646.3 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..75 | ||
| AXIN1_TNKS_BD | 10..75 | CDD:465215 | |||
| Tankyrase-binding motif | 21..30 | ||||
| RGS_Axin | 82..198 | CDD:188662 | |||
| Interaction with GSK3B. /evidence=ECO:0000250 | 327..413 | ||||
| Interaction with SIAH1 and SIAH2. /evidence=ECO:0000269|PubMed:28546513 | 334..393 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 396..435 | ||||
| Interaction with beta-catenin. /evidence=ECO:0000250 | 413..476 | ||||
| Axin_b-cat_bind | 433..468 | CDD:462616 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 447..494 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 561..674 | 8/38 (21%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 718..748 | 6/40 (15%) | |||
| DAX | 761..843 | CDD:197474 | 19/80 (24%) | ||
| axl-1 | NP_001040672.1 | DIX | 318..386 | CDD:470574 | 17/67 (25%) |
| Blue background indicates that the domain is not in the aligned region. | |||||