DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AXIN2 and pry-1

DIOPT Version :10

Sequence 1:NP_004646.3 Gene:AXIN2 / 8313 HGNCID:904 Length:843 Species:Homo sapiens
Sequence 2:NP_493474.2 Gene:pry-1 / 173287 WormBaseID:WBGene00004202 Length:586 Species:Caenorhabditis elegans


Alignment Length:639 Identity:129/639 - (20%)
Similarity:217/639 - (33%) Gaps:154/639 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    78 WTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNL--KDTKTLRVAKAIYKRYIE 140
            |.:||.::|.|:.....|:.:|........||.:||...:.:|.|  |..|: :::|:||.:::.
 Worm     7 WARSLEAVLSDRSALDAFQEWLIEYSSPQYLDLFFAIRAYERMALEGKPEKS-QLSKSIYSKFLS 70

Human   141 ----NNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVR 201
                |...:.|..:......:|.|   .:::..:|......:|..:... ::.|:.|:.::|...
 Worm    71 SRTGNCEAIPKHFRAPIGEKLRHG---TELEDRVFSHCSNFVQEFLRRQ-HEEFVGSEEFIEAFN 131

Human   202 SGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFKCKLSPTVVGLSSKTLRATASVRSTET 266
            .....||....||.....   .:..|:......|......::        :..|.|.|.::|...
 Worm   132 KMSSTTADQLPGGSAHHS---SHQNTMRRSSGTTSRKSAAQI--------ATQLTAEALLKSKHD 185

Human   267 VDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPP--YRVGS 329
            ..|.....|......|..  ..||....||.|||.:|             |:..|..|  :|:.|
 Worm   186 RHSKLGETKLEKMYPPTR--QPYVCNATTSHNDSAVS-------------STFSGDTPEAHRMHS 235

Human   330 KK------QLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPAT----------------FAA 372
            .:      :..||.|      |.::||.             ||.|:                ||.
 Worm   236 NRLRHIRDEQARENH------GTMTLPR-------------VEKASVDGQQWDHSSESGRRNFAM 281

Human   373 E----LISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYEE 433
            |    |:..::|:||..|    :|:|:     |:..|....|::...|......|     |..:|
 Worm   282 EITRKLLRHIDKVKLNDE----MEKRI-----DDIEECRYTTIDMVNGTEPNDDL-----GKIDE 332

Human   434 DPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACP 498
            |.:  |||:| ::..|...|.....| ||:..:.:.:.......::.|.|..:.|....:....|
 Worm   333 DEE--LDDYL-KMKMTDDSQKGSTNR-SPKGPAGEPNKSGEGSKNTTLSPTNRAPAQLHNTIRVP 393

Human   499 LLGGKGFVTKQTTKHVHHHYIHHHAVPK---------------TKEEIEAEATQRVHCFCPG--- 545
            ........|..:.|...||.|..:.:..               :::......|.||: |.||   
 Worm   394 RRKDYPRDTSASLKSHRHHQIDTNRMMSQSMCAPSYSSASSSYSRDSFAPAPTTRVN-FAPGSSK 457

Human   546 GSEYY-------------------CYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTE---- 587
            .|::|                   .|...:.|.|||......:.|.:. |.|...:..||:    
 Worm   458 SSQFYDSSGIGSMAPSAFSATSSLDYKDRRQHRKAPTPKKHSKIGKNL-SNLITISYLGTDKIPV 521

Human   588 ----PG-----LALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQSKP 632
                |.     ||...|....|.||..|....|..|.|......:::.|....|
 Worm   522 VTHVPNDGPMTLAEFKRHFALPNGAHQLFFKTECEDGSAPFQLLLIKDEHHLLP 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AXIN2NP_004646.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..75
AXIN1_TNKS_BD 10..75 CDD:465215
Tankyrase-binding motif 21..30
RGS_Axin 82..198 CDD:188662 24/121 (20%)
Interaction with GSK3B. /evidence=ECO:0000250 327..413 23/111 (21%)
Interaction with SIAH1 and SIAH2. /evidence=ECO:0000269|PubMed:28546513 334..393 17/78 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 396..435 7/38 (18%)
Interaction with beta-catenin. /evidence=ECO:0000250 413..476 14/62 (23%)
Axin_b-cat_bind 433..468 CDD:462616 11/34 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 447..494 8/46 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 561..674 20/85 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..748
DAX 761..843 CDD:197474
pry-1NP_493474.2 RGS 10..128 CDD:470619 25/122 (20%)
Blue background indicates that the domain is not in the aligned region.

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