Protein Alignment AXIN2 and axin2

DIOPT Version :10

• Sequence 1: NP_004646.3
• Gene: AXIN2 / 8313
• HGNCID: 904
• Length: 843
• Species: Homo sapiens
• Sequence 2: XP_031750071.1
• Gene: axin2 / 116406464
• XenbaseID: XB-GENE-29072348
• Length: 728
• Species: Xenopus tropicalis
• Alignment Length: 854
• Identity: 456/854 - (53%)
• Similarity: 536/854 - (62%)
• Gaps: 137/854 - (16%)

Human     1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNEDGLGEP 65
            |||::|...|...||||||||||||||||||.| |||| ..:.|.:||.|||||.||:..|||||
 Frog     1 MSSSLLGAQLSHLSSSFREDAPRPPVPGEEGHT-PCQP-PARSQRSKPAPVSSNPRRDAGGLGEP 63

Human    66 EGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRV 130
            ||.|||||||.||.|||||||||::||.|||.||||::|||||||||||||||||:..|.|||||
 Frog    64 EGSASPDSPLARWAKSLHSLLGDKEGADLFRRFLERQRCVDTLDFWFACNGFRQMDPGDAKTLRV 128

Human   131 AKAIYKRYIEN--NSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTS 193
            ||||||||||:  ...|:|||||.||:::||.:|.|::|..||||||.|:|:.||:|||::||:|
 Frog   129 AKAIYKRYIESGGGGTVAKQLKPPTKSFLRDCVKGQRLDPSMFDQAQAEVQASMEDNAYRLFLSS 193

Human   194 DIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFKCKLSPTVVGLSSKTLRAT 258
            ||||||    |||.||.|:.....|..|.||||||||||||:|.|.:.|..|:|:|||:|.||||
 Frog   194 DIYLEY----GENAAYFSSAESAGLGGVTGYLPTLNEEEEWSCVDLRQKSLPSVLGLSTKALRAT 254

Human   259 ASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIP 323
            .|:|:.|..:|||||.:|:||.||||     |||||||||:||:||||:||||:|:||||||.|.
 Frog   255 ISLRAKEPAESGYRSHRRNDPTNPYH-----VFAPATSANESEVSSDAMTDDSLSITDSSVDSIA 314

Human   324 PYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESR 388
            |||:|||||||.||.|||||||.||||.||||||||.||||:|||.||||||.||||:|..||.|
 Frog   315 PYRMGSKKQLQWEMARSVKANGLVSLPPFPRTHRLPSEMTPMEPAVFAAELIVRLEKVKENLEER 379

Human   389 HSLEERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQ 453
            .|.||   |...:||.|..|..:.....:|...||..||.|:. ::||.||||||||||||||||
 Frog   380 GSSEE---QHHTEEEEEDCETPVFLHPTSPPYQPLPSLPLGAM-KNPQAILDDHLSRVLKTPGCQ 440

Human   454 SPGVGRYS-PRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLL---GGKGFVTKQTTKHV 514
            |||:.|:: |.||                    :.||:.|.|.|...|   ..|||..|.|||||
 Frog   441 SPGMDRHTCPSSR--------------------QTPPSVAQPAAGTALRSPXAKGFANKPTTKHV 485

Human   515 HHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLP 579
            ||||||                                   :||...||.:         |.|:
 Frog   486 HHHYIH-----------------------------------QSHPPIPEEL---------GRTV- 505

Human   580 KRNGKGTEPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQSKP-----KPHSAQS 639
                             .|:|     ::|.|..                   |     .|||.|.
 Frog   506 -----------------CGSP-----VRLQRHH-------------------PFHAFLYPHSLQH 529

Human   640 TKKAYPLESARSSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRL 704
            :||..|:| .||...||...||.||..:||||:.|.:|...|:...||:..|:||||||||||||
 Frog   530 SKKNPPIE-PRSLSAERPPHHHTWGTCTGHPRSLPPSHPSAQELPAPPVPTPSTLAQLEEACRRL 593

Human   705 AEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYF 769
            ...|:.||..........:..|...|.|.....:.|...   |||||: ..|......||:||||
 Frog   594 TGASQAPKAEMFRYWATENPPHPQPVGTRTPSHTCPGAC---HKEPKR-PPVPLDPPGELMVTYF 654

Human   770 FCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGR 834
            ||.|:|||||:||:.|||||||||||||||||||||||||:||.||||||||..|:|:||.||||
 Frog   655 FCEEQIPYRRLLKSHSLTLGHFKEQLSKKGNYRYYFKKASEEFECGAVFEEIRGDDTMLPTYEGR 719

Human   835 ILGKVERID 843
            :||||||||
 Frog   720 VLGKVERID 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AXIN2	NP_004646.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		50/73 (68%)
		AXIN1_TNKS_BD	10..75	CDD:465215	46/64 (72%)
		Tankyrase-binding motif	21..30		8/8 (100%)
		RGS_Axin	82..198	CDD:188662	81/117 (69%)
		Interaction with GSK3B. /evidence=ECO:0000250	327..413		57/85 (67%)
		Interaction with SIAH1 and SIAH2. /evidence=ECO:0000269|PubMed:28546513	334..393		44/58 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..435		11/38 (29%)
		Interaction with beta-catenin. /evidence=ECO:0000250	413..476		31/63 (49%)
		Axin_b-cat_bind	433..468	CDD:462616	25/35 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..494		17/47 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..674		29/117 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	718..748		4/29 (14%)
		DAX	761..843	CDD:197474	65/81 (80%)
axin2	XP_031750071.1	Axin_TNKS_binding	12..71	CDD:211424	43/60 (72%)
		RGS_Axin	80..198	CDD:188662	81/117 (69%)
		Axin_b-cat_bind	420..458	CDD:462616	26/57 (46%)
		PHA03378	<446..>646	CDD:223065	87/310 (28%)
		DIX	651..724	CDD:459936	59/72 (82%)