Protein Alignment AXIN1 and RGS2

DIOPT Version :10

• Sequence 1: XP_011520984.1
• Gene: AXIN1 / 8312
• HGNCID: 903
• Length: 916
• Species: Homo sapiens
• Sequence 2: NP_014750.3
• Gene: RGS2 / 854274
• SGDID: S000005633
• Length: 309
• Species: Saccharomyces cerevisiae
• Alignment Length: 276
• Identity: 56/276 - (20%)
• Similarity: 106/276 - (38%)
• Gaps: 52/276 - (18%)

Human   112 RSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKL 176
            |||.|       :.|.....::..:..|..:.....|..|..|||:..|.:.|:|:.....|.:|
Yeast    19 RSDGD-------AESSNTVLIQLRKGHHERMRSPYTIQKFYKFLKRAHCEENLEFFEKAHQFLQL 76

Human   177 EPCDS-NEEKRLKL-ARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQ--AQTE 237
            :...| :|||.|:: .:::|.|||..::......::. |:...:.|.....: ||..|.  |.:.
Yeast    77 KQNRSISEEKLLEVWNKSLYIKYIAVDSPKECNFSQD-TREIFEKCFANNEV-PADVDVLCAISH 139

Human   238 IQATMEENTYPSFLKSDIYLEYTRT----GSESPKVCSDQSSGSGTGKGISGYLPTLNEDEEWKC 298
            :...:.:. |..|:.|....:|:.|    .|.:.:...::|:.|.:..|:
Yeast   140 VMGLLMDG-YHRFVSSVNEKKYSATYAHNDSATEQDLKNESTTSFSSLGV--------------- 188

Human   299 DQDMDEDDGRDAAPPGRLPQKLLLE---------------TAAPRVSSSRRYSEGREFRYGSWR- 347
             :|:.||.......|.......:::               |:.|..|||...:....::..|.|
Yeast   189 -EDISEDRNSYLKKPDINGLSTIIQETSANTTNESQCSDRTSRPSESSSSLNTTSSTYKNTSTRN 252

Human   348 --EPVNPYYVNAGYAL 361
              :|.|...:|:|..|
Yeast   253 LQKPQNTGILNSGKGL 268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AXIN1	XP_011520984.1	Axin_TNKS_binding	60..129	CDD:211424	5/16 (31%)
		RGS_Axin	138..258	CDD:188662	29/123 (24%)
		Axin_b-cat_bind	519..550	CDD:462616
		DIX	836..912	CDD:459936
RGS2	NP_014750.3	RGS	42..154	CDD:188659	27/114 (24%)