Protein Alignment AXIN1 and Axn

DIOPT Version :9

• Sequence 1: XP_011520984.1
• Gene: AXIN1 / 8312
• HGNCID: 903
• Length: 916
• Species: Homo sapiens
• Sequence 2: NP_733336.1
• Gene: Axn / 43565
• FlyBaseID: FBgn0026597
• Length: 745
• Species: Drosophila melanogaster
• Alignment Length: 987
• Identity: 226/987 - (22%)
• Similarity: 356/987 - (36%)
• Gaps: 400/987 - (40%)

Human    70 PRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKW 134
            |||||||||..:....           :||.                     :.|.:.:|.||.|
  Fly    19 PRPPVPGEESRVKKMT-----------EGVA---------------------DTSKNSSPSYLNW 51

Human   135 AESLHSLLDDQDGISLFRTFLKQEGCA--DLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKY 197
            |.:|:.||:|:||:.||:.::::|..|  |.|:|:|||.|.::    .::.||..::..|||| :
  Fly    52 ARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQ----QTDPEKIKQIIGAIYR-F 111

Human   198 ILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRT 262
            :..:...:|...:...|:......:.  :.|.:||..|..::.|:.:|.||:||.|::|:.|.:.
  Fly   112 LRKSQLSISDDLRAQIKAIKTNPEIP--LSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQ 174

Human   263 GSESPKVCSDQ---------SSGSG---------------TGK------------------GISG 285
            .|...:.|:..         |||||               :||                  .:||
  Fly   175 MSAQQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQLVPPGAFINLPVSSVSG 239

Human   286 -----------------------------------YLPTLNEDEEWK-CDQ----DMDEDDGR-- 308
                                               .||||:||.... ||.    .|.|..|.
  Fly   240 PPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLG 304

Human   309 -------DAAP--PGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPA 364
                   ..||  |.||.:.||:.|...|:......:.|..:         ||...|..|.   .
  Fly   305 SGSVGAGARAPDYPIRLTRDLLIATQKRRLEIRPPGAHGYVY---------NPSTTNTSYV---P 357

Human   365 TSANDSEQQSLSS----DADTLSLTDSSVDGIPPYRIRKQH----RREMQESVQVNGRVPLPHIP 421
            .|..|||:.|:||    |:||:|::..|:|| .|| |:::|    .:.:::|...|
  Fly   358 NSRVDSERASVSSGGRTDSDTMSISSCSMDG-RPY-IQRRHSSTESKAIRQSAMAN--------- 411

Human   422 SCPSQRTYRV-PKEVRV---EPQKFAEE-----LIHRLEAVQRTREAEEKLEERLKRVRM--EEE 475
              ....|::| |:..|:   |.:...||     ||.:||.|:|.|:.||:..||.....:  .|.
  Fly   412 --KETNTFQVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAALLTNER 474

Human   476 GEDGDPSSGPPGPCHKLPPAPAWHHFPPRCVDMGCAGLRD---AHEENPESILDEHVQRVL---- 533
            ....|.:.                          ...:|:   ..|:|.:.|||:||.||.
  Fly   475 SSASDRAF--------------------------AEAIREKFALDEDNDQDILDQHVSRVWKDQT 513

Human   534 --RTPGRQSPGPGHRS------PDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLHHHRHVH 590
              |:||..||.|...|      .|||.|:...::|.|.:..|.|.:|.
  Fly   514 PHRSPGTMSPCPPIPSRRRTATHDSGMVSDGAMSLSGHSMKHSKSMPD----------------- 561

Human   591 HHVHHSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVA 655
               |.|.:|       :.|.:      |                   .:.|...|::
  Fly   562 ---HSSCSR-------KLTNK------W-------------------PSMNTDSGIS-------- 583

Human   656 CKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQPHENSR 720
             ..:|......|.||:                              |:|..::
  Fly   584 -MFSADTVTKYKDASS------------------------------RSGSSTA------------ 605

Human   721 PLSLEHPWAGPQLRTSVQPSHLFIQDPTMPPHPAPNPLTQLEEARRRLEEEEKRASRAPSKQRYV 785
                                                  ::||||:||||:|.:|:      :||.
  Fly   606 --------------------------------------SKLEEAKRRLEDEPRRS------RRYA 626

Human   786 QEVMRRGRACVRPACAPVLHVVPAVSDMELSETETRSQRKVGGGS-----------AQPCDSIVV 839
            |              .|:.|    :|...|:...:.|    .|||           |:|.::|||
  Fly   627 Q--------------PPMQH----LSQQPLASFSSSS----SGGSISLPHQPPPLPAKPPETIVV 669

Human   840 AYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVF 904
             :.||.||:|||..:.|...||.|||:.|.::|.:|::||...::.|..|:.||:..|..:||:|
  Fly   670 -FSFCEEPVPYRIKIPGTQPTLRQFKDYLPRRGHFRFFFKTHCEDPDSPVIQEEIVNDSDILPLF 733

Human   905 EEKIIGKVEKVD 916
            .:|.:|.|:..|
  Fly   734 GDKAMGLVKPSD 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AXIN1	XP_011520984.1	Axin_TNKS_binding	60..129	CDD:211424	12/58 (21%)
		RGS_Axin	138..258	CDD:188662	37/121 (31%)
		Axin_b-cat_bind	518..574	CDD:285982	25/67 (37%)
		DIX	836..911	CDD:279160	30/74 (41%)
Axn	NP_733336.1	RGS	55..170	CDD:295367	37/121 (31%)
		Axin_b-cat_bind	494..543	CDD:285982	20/48 (42%)
		DIX	665..739	CDD:279160	30/74 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9652
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4120
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50119
OrthoDB	1	1.010	-	-		D1481971at2759
OrthoFinder	1	1.000	-	-		FOG0003472
OrthoInspector	1	1.000	-	-		otm41491
orthoMCL	1	0.900	-	-		OOG6_105312
Panther	1	1.100	-	-	O	PTHR46102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4975
SonicParanoid	1	1.000	-	-		X2363
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870