DRSC/TRiP Functional Genomics Resources

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Protein Alignment AXIN1 and rgs1

DIOPT Version :10

Sequence 1:XP_011520984.1 Gene:AXIN1 / 8312 HGNCID:903 Length:916 Species:Homo sapiens
Sequence 2:NP_593029.1 Gene:rgs1 / 2541764 PomBaseID:SPAC22F3.12C Length:481 Species:Schizosaccharomyces pombe


Alignment Length:200 Identity:39/200 - (19%)
Similarity:70/200 - (35%) Gaps:48/200 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    83 STDPRPASYS-----FCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLL 142
            |..|...||:     |.:|||:...|.|...:..:....:....:||.:        .|.|.::|
pombe   293 SETPLKFSYAKGVSYFLTGKGIATLGWTKNVSNNKLINKINEVEKGSTN--------KEILETIL 349

Human   143 DDQDGISLFRTFLKQEGCADLLDFWFACTGFRK-----------------------LEPC--DSN 182
            ...:..:.|..|||:..|.:...|:.....|..                       :..|  .||
pombe   350 RKPNLQTYFFEFLKKNFCDENQRFYSEVCEFNDYFSHANETNDHEAIRESFAHACGIYNCFLSSN 414

Human   183 EEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTY 247
            ....:.|...:|.|  :.|:..::.:.:|..:       ..|||...:. :|||.:...|..::.
pombe   415 APNAVNLPSDLYEK--ITNHMALAMEVEPLNE-------WLQLIHILLL-EAQTAVLDLMAGDSL 469

Human   248 PSFLK 252
            ..||:
pombe   470 LKFLE 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AXIN1XP_011520984.1 Axin_TNKS_binding 60..129 CDD:211424 12/50 (24%)
RGS_Axin 138..258 CDD:188662 26/139 (19%)
Axin_b-cat_bind 519..550 CDD:462616
DIX 836..912 CDD:459936
rgs1NP_593029.1 DEP 59..156 CDD:214489
DEP_RGS7-like 224..309 CDD:239897 4/15 (27%)
RGS_FLBA 344..480 CDD:188663 26/140 (19%)
Blue background indicates that the domain is not in the aligned region.

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