Protein Alignment AXIN1 and axl-1

DIOPT Version :10

• Sequence 1: XP_011520984.1
• Gene: AXIN1 / 8312
• HGNCID: 903
• Length: 916
• Species: Homo sapiens
• Sequence 2: NP_001040672.1
• Gene: axl-1 / 186869
• WormBaseID: WBGene00010497
• Length: 400
• Species: Caenorhabditis elegans
• Alignment Length: 290
• Identity: 62/290 - (21%)
• Similarity: 110/290 - (37%)
• Gaps: 70/290 - (24%)

Human   131 YLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYR 195
            :.||.:...|  .:.|.|:|:.:.|..|.               ||: ..|.....|||||.|:|
 Worm    18 FAKWCQKEES--RNADSITLYTSILDFES---------------KLK-TGSPSLSLLKLARHIHR 64

Human   196 KYILDNNGIV-----SRQTKPATKSFIKGCIMKQLID--PAMFDQAQTEIQATMEENTYPSF--L 251
            ||:..|.|..     |.:||.:|:       :.:::|  |...|        ..:....|.|  |
 Worm    65 KYVSLNTGTCHVIGDSIRTKISTR-------VHEVLDGKPPYID--------LFDPLKQPLFQHL 114

Human   252 KSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRL 316
            :| ::.|::.|.::......|.||.|.:.||.:.:   .|||   ..|:....:.|:........
 Worm   115 RS-MHTEFSTTTADVNTTWEDASSTSSSNKGATIW---FNED---AIDKSSRHEIGQSTVTHESE 172

Human   317 PQKL-LLETAAPRVSS---SRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSS 377
            ..:. .......|::|   ::..||..|......:|..:..|...|:|..|.           |:
 Worm   173 DDRFSFFNAVCTRLNSLQETKNSSETEEHAESPRKEKSSTPYGTDGFAPPPR-----------ST 226

Human   378 DADTLSLTDSSVDGIPPYRIRKQHRREMQE 407
            ..:||.:::.      |.|....::::.|:
 Worm   227 QTNTLKVSNL------PKRFESLYKKKRQQ 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AXIN1	XP_011520984.1	Axin_TNKS_binding	60..129	CDD:211424
		RGS_Axin	138..258	CDD:188662	31/128 (24%)
		Axin_b-cat_bind	519..550	CDD:462616
		DIX	836..912	CDD:459936
axl-1	NP_001040672.1	DIX	318..386	CDD:470574