Protein Alignment PICALM and picalm

DIOPT Version :10

• Sequence 1: XP_005274379.1
• Gene: PICALM / 8301
• HGNCID: 15514
• Length: 686
• Species: Homo sapiens
• Sequence 2: XP_031751621.1
• Gene: picalm / 100327242
• XenbaseID: XB-GENE-5749321
• Length: 709
• Species: Xenopus tropicalis
• Alignment Length: 715
• Identity: 579/715 - (80%)
• Similarity: 631/715 - (88%)
• Gaps: 35/715 - (4%)

Human     1 MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFE 65
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
 Frog     1 MSGQSITDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADTLFE 65

Human    66 RTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRY 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    66 RTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRY 130

Human   131 LNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINA 195
            |||||||||||||||||||||.|||||||:|||||||:||||||||||||||||:||||||||||
 Frog   131 LNEKAVSYRQVAFDFTKVKRGTDGVMRTMSTEKLLKTMPIIQNQMDALLDFNVNANELTNGVINA 195

Human   196 AFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGID 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   196 AFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGID 260

Human   261 RGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQ 325
            ||||||||||||||||||||||||||||||||||||||||||||||||||:|.||||:|||||||
 Frog   261 RGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLATTSLSLTRVDEREKQ 325

Human   326 AALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLP 390
            |||||||||||||||||:|||:||||::.|||:||||::||.|.|..|||:|:||:|.|  |||.
 Frog   326 AALEEEQARLKALKEQRVKELSKKPHSTSTTASSPVSSTAGSINTTAAIDMFATPTSLN--SKLS 388

Human   391 NDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLS-ISSD 454
            |||||: ||||.|:|||:|...|||.:|.|||  |.:|.||:||||||||:|:|..|.|. :|:|
 Frog   389 NDLLDM-QPTFQPAVHPLSAVPQVAGSWADPF--TSEAADDSIPSLNPFLSKASEGVQLPVVSTD 450

Human   455 VSTFTTRTPTHEMFV---------------------------GFTPSPVAQPHPSAGLNVDFESV 492
            .:.:|.:||:||:|:                           |||||...||..|.||||||:||
 Frog   451 SANYTAKTPSHEIFIDSFCGPQGYPNPSHFRSEPSTVAGLYGGFTPSLAVQPQTSGGLNVDFDSV 515

Human   493 FGNKS-TNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNG 556
            ||||| ::|.|||..||:|||||||||||.|||||..|.|.:|||||||||||||||||||||||
 Frog   516 FGNKSPSSVNVDSAAFDDLGGLLKPTVASLNQNLPSCKNPQNKLVSDDLDSSLANLVGNLGIGNG 580

Human   557 TTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMNGMHFPQYAPPVMAYPATTPTGMIGYGI 621
            |||||::||||||||||||:||||||||||.||.||:|||||||||||:||||||||||::|||:
 Frog   581 TTKNDIHWSQPGEKKLTGGTNWQPKVAPTTTWNPATLNGMHFPQYAPPIMAYPATTPTGIVGYGM 645

Human   622 PPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQLSAASSPSSHSPHRASGKDPFAELSLEDFL 686
            || ||.|||:.||.|||:||||||||||||||||||.||.||||.|||||.|:|.:.:|||:|||
 Frog   646 PP-MGPVPVIQQPPLIYNQPVMRPPNPFGPVSGAQLPAAPSPSSQSPHRAPGEDRYPQLSLQDFL 709

Human   687  686
             Frog   710  709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PICALM	XP_005274379.1	ANTH	24..282	CDD:400137	252/257 (98%)
picalm	XP_031751621.1	ANTH	24..282	CDD:400137	252/257 (98%)
		PHA03378	<601..>702	CDD:223065	81/101 (80%)