Protein Alignment TRRAP and Nipped-A

DIOPT Version :9

• Sequence 1: NP_001362453.1
• Gene: TRRAP / 8295
• HGNCID: 12347
• Length: 3873
• Species: Homo sapiens
• Sequence 2: NP_001097192.2
• Gene: Nipped-A / 35483
• FlyBaseID: FBgn0053554
• Length: 3790
• Species: Drosophila melanogaster
• Alignment Length: 3935
• Identity: 2037/3935 - (51%)
• Similarity: 2725/3935 - (69%)
• Gaps: 238/3935 - (6%)

Human    21 YLQFVAALTDVNTPDETKLKMMQEVSENFENVTSSPQYSTFLEHIIPRFLTFLQDGEVQFLQEKP 85
            :..::..|.|.::.||.|||..||:||:||.:..||.|.:||::.:..|:..|||||.||:||..
  Fly    12 FRNYLNILNDSSSKDELKLKATQELSEHFEMIMQSPAYPSFLDNSLKIFMRILQDGEPQFIQENT 76

Human    86 AQQLRKLVLEIIHRIPTNEHLRPHTKNVLSVMFRFLETENEENVLICLRIIIELHKQFRPPITQE 150
            .|.:|||:||:|||:|..|.||.|.|.::::|.:.|:|:||||||:||||||||||.|||....|
  Fly    77 MQHIRKLILEMIHRLPITESLRQHVKTIITMMLKILKTDNEENVLVCLRIIIELHKHFRPSFNSE 141

Human   151 IHHFLDFVKQIYKELPKVVNRYFE-------------NPQVIPENTVPPPEMVGMITTIAVKVNP 202
            |..||.|||:||..||..:...||             |.:|:...:.       .:.||.|:...
  Fly   142 IQLFLGFVKEIYTNLPNHLTSIFETSNDVWVTDLKDLNLEVLLSESY-------SVRTIHVEKAL 199

Human   203 EREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYKLNIHNVVAEFVPLIMNTIAIQVSAQAR 267
            : .:|:.:.::::|||.||||||.|||||||||||:||..:|..|:||:|||:.||.:|.:...|
  Fly   200 D-SNSQQQIYNLLPRGILSLKVLQELPIIVVLMYQIYKNAVHQEVSEFIPLILTTINLQPTVTRR 263

Human   268 QHKLYNKELYADFIAAQIKTLSFLAYIIRIYQELVTKYSQQMVKGMLQLLSNCPAETAHLRKELL 332
            ...  .||:|.:|:.||||||||||||:||:||:|...|..:..|||.|:.|||.|.||||||||
  Fly   264 NSP--QKEIYVEFMGAQIKTLSFLAYIVRIFQEVVIASSLSVTSGMLNLMKNCPKEAAHLRKELL 326

Human   333 IAAKHILTTELRNQFIPCMDKLFDESILIGSGYTARETLRPLAYSTLADLVHHVRQHLPLSDLSL 397
            |||:||..|:||.:|||.:::||||.:|||.|.|. :::|||||||||||.|||||.|.:..|..
  Fly   327 IAARHIFATDLRQKFIPSIEQLFDEDLLIGKGVTL-DSIRPLAYSTLADLAHHVRQSLNIDVLIK 390

Human   398 AVQLFAKNIDDESLPSSIQTMSCKLLLNLVDCIRSKSEQESGNGRDVLMRMLEVFVLKFHTIARY 462
            ||.||:||:.||||...|||||||||||||||:|..||.|....:.:|.::|:|||.||.|||:.
  Fly   391 AVNLFSKNVHDESLAVGIQTMSCKLLLNLVDCLRHHSETEPQRSKALLSKLLKVFVKKFETIAKI 455

Human   463 QLSAIFKKCKPQSELGAVEAALPGVPTAPAAPGPAPSPAPVPAPPPPPPPPPPATPVTPAPVPPF 527
            ||..|.:|||..:..||:          ..:.|.| |.:.:.||..
  Fly   456 QLPLIIQKCKGHAFSGAL----------VNSSGNA-SLSHINAPDL------------------- 490

Human   528 EKQGEKDKEDKQTFQVT-------------DCRSLVKTLVCGVKTITWGITSCKAPGEAQFIPN- 578
                   |:|....||:             :.||||||||.||||||||..:.|.......:.|
  Fly   491 -------KDDISNIQVSASGSQWIYSVNVAEFRSLVKTLVGGVKTITWGFFNSKFQLTDTKLANH 548

Human   579 -KQLQPKETQIYIKLVKYAMQALDIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMM 642
             |...|:....||.||.|||:|||||.:.:..|.|....:.:    |.||||||||||:|:|.||
  Fly   549 EKIFGPEIVCSYIDLVYYAMEALDIYTINVNPNQQRTSGLIS----RSKEEKEVLEHFSGIFLMM 609

Human   643 NPLTFKEIFQTTVPYMVERISKNYALQIVANSFLANPTTSALFATILVEYLLDRLPEMGSNVELS 707
            :...|:|||.||:.::||||.||.:||::|||||||||||.||||:||||||:::.|||||:|.|
  Fly   610 HSQNFQEIFSTTINFLVERIYKNQSLQVIANSFLANPTTSPLFATVLVEYLLNKMEEMGSNLERS 674

Human   708 NLYLKLFKLVFGSVSLFAAENEQMLKPHLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSH 772
            ||||:||||||||||||..||||||:||||||||.|||||..::|||||||||||||||||||||
  Fly   675 NLYLRLFKLVFGSVSLFPVENEQMLRPHLHKIVNRSMELALISEEPYNYFLLLRALFRSIGGGSH 739

Human   773 DLLYQEFLPLLPNLLQGLNMLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNG 837
            |||||||||||||||:|||.||||.|||||:||||||||||||||||||||||||||||||||||
  Fly   740 DLLYQEFLPLLPNLLEGLNRLQSGFHKQHMRDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNG 804

Human   838 SQTLVSQGLRTLELCVDNLQPDFLYDHIQPVRAELMQALWRTLRNPADSISHVAYRVLGKFGGSN 902
            |.||:||||||||||||||||||||||||||||.||||||:|||| .|:.:.||:||||||||.|
  Fly   805 SPTLISQGLRTLELCVDNLQPDFLYDHIQPVRAALMQALWKTLRN-QDNAALVAFRVLGKFGGGN 868

Human   903 RKMLKESQKLHYVVTEVQGPSITVEFSDCKASLQLPMEKAIETALDCLKSANTEPYYRRQAWEVI 967
            |||:.|.|.|.|::.:....||...|.:.:..:..|:::||::|...|.|.:|:.:||||:||||
  Fly   869 RKMMVEPQALSYIINDKPTISIVTYFQEYETPIDFPVDEAIKSAFRALGSNSTDQFYRRQSWEVI 933

Human   968 KCFLVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQDTPARKTFEQALTGAFMSAVIK 1032
            :|||.|.:||:|.||.|.:|..|.:|.|..|.| ..:.::||.:...|:|.:.||.|..:::..|
  Fly   934 RCFLAAFISLDDEKHMLLKLFTHVDFVENKIMN-WSTFQHKAGNETVRETHQTALIGMLVASATK 997

Human  1033 DLRPSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFHSEENGSKGMDPLVLIDAIA 1097
            |||.|..|.:|:::|||||||:|||.|||....||               .:.|:||::||||:|
  Fly   998 DLRDSVCPVMAAVVRHYTMVAIAQQAGPFPQKGYQ---------------ATHGIDPMILIDALA 1047

Human  1098 ICMAYEEKELCKIGEVALAVIFDVASIILGSKERACQLPLFSYIVERLCACCYEQAWYAKLGGVV 1162
            .||.:|||||||.|...:.:|.|.|:.|:|:|:|||:||:..|:.|::.:.||::.||:|:||..
  Fly  1048 SCMGHEEKELCKPGIACMGIILDTATNIMGNKDRACKLPIIQYLAEKMVSLCYDRPWYSKVGGCQ 1112

Human  1163 SIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSNGAVAMAKTTLEQLLMRCATPLKDEERA 1227
            :|:||.:.:.|..:.||...||||.:||:|||.|:|||||:.:.|:.::.:|..|.||:.:..:.
  Fly  1113 AIQFLCKHMSLRALFQNLFNFLKAFMFVLMDLEGDVSNGAIEITKSYMKSMLEICLTPINECYKN 1177

Human  1228 EEIVAAQEKSFHHVTHDLVREVTSPNSTVRKQAMHSLQVLAQVTGKSVTVIMEPHKEVLQDMVPP 1292
            .::...|.|:.:.|.|:|||.:||||:.||:::|..|:.:..:..|:|:.:|:|||:||.|::||
  Fly  1178 IDLKDLQAKATYEVIHELVRHITSPNTIVREESMVLLKHIGTIQSKTVSEVMDPHKDVLADIIPP 1242

Human  1293 KKHLLRHQPANAQIGLMEGNTFCTTLQPRLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYK 1357
            |||||||||||||||||:||||||||:|||||:||....||:|:.|||.|.||||:.|.||.|||
  Fly  1243 KKHLLRHQPANAQIGLMDGNTFCTTLEPRLFTIDLTNTYHKLFFHELLTLSEAEDATLAKLDCYK 1307

Human  1358 SLPSLVPLRIAALNALAACNYLPQ--SREKIIAALFKALNSTNSELQEAGEACMRKFLEGATIEV 1420
            ::|:|:|||.:||.|||||:|:..  .:||||..:||.:.|..||||.....||:.|:.|.|:|.
  Fly  1308 NVPNLIPLRTSALRALAACHYISDIGYKEKIINIIFKVMESDKSELQTTAFHCMKHFITGVTLEK 1372

Human  1421 DQIHTHMRPLLMMLGDYRSLTLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGG 1485
            :::.:.|||||:.|||:|:|::..:.||:..|::||..||:|..:|::||..|.||:.|..:|.
  Fly  1373 EKVQSAMRPLLLKLGDHRNLSIPAIKRLSYFTQIFPQMFNEKLSEQILQHCSKIMEIFVSEYKS- 1436

Human  1486 QRSDGNESISECGRCPLSPFCQFEPAMEGVE-EMKICSAIINLFHLIPAAPQTLVKPLLEVVMKT 1549
                            .||...|..:.:|.| |.||. .:|.:|..|.|:.:.:.| |.::|:||
  Fly  1437 ----------------TSPNVNFFASSKGGEYEQKIV-ILIEMFFYISASVKYIEK-LCQLVLKT 1483

Human  1550 ERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDARPLRDVL-AA 1613
            |:.::|||.||:||.|||||.|.|::||:||:.|:.:.||||:|:|:..|||:.....|.|: ::
  Fly  1484 EKNLMIEASSPYREALIKFLQRFPTETVDLFLTESLMIDPQWNRLFIYLLKHETGVSFRAVIKSS 1548

Human  1614 NPNRFITLLLPGGAQTAVRPGSPSTST-----MRLDLQFQAIKIISIIVKNDDSWLASQHSLVSQ 1673
            ..|..|..|              :|.|     ::.::|.||:.||..::::||.|:.::..:|..
  Fly  1549 RYNNLIHYL--------------NTHTEFPEALKYEIQHQAVLIIFTLMESDDQWIPTRQDIVDA 1599

Human  1674 LRRVWVSENFQERHRKENMAATNWKEPKLLAYCLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTF 1738
            |:..|  :|:......|::....|   .|:...||:|...|..|||||||||||...||:.::.|
  Fly  1600 LKNCW--QNYLSTLSSEDVLCDLW---HLIGKILLHYFSNNTNDIELLFQLLRALCFRFIPDVYF 1659

Human  1739 LKEYMEEEIPKNYSIAQKRALFFRFVD-FNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQLLG 1802
            |:::::..:.:::::..||..||.||: ||:....:|||||::..::.|.|..||:||||.:|:|
  Fly  1660 LRDFLQHTVAQSFTVNWKRNAFFYFVENFNNSFLSEELKAKIITAVIIPCFAVSFDKGEGNKLIG 1724

Human  1803 -PPNPEGDNPESITSVFITKVLDPEKQADMLDSLRIYLLQYATLLVEHAPHHIHD---NNKNRNS 1863
             ||.|..::.::|.||||.||.||:||.|  |::||.|||.|.||||.|..||||   |||.:.:
  Fly  1725 APPTPYQEDEKNIVSVFINKVFDPDKQYD--DAVRIALLQLACLLVERASQHIHDGDANNKRQGN 1787

Human  1864 KLRRLMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIVR 1928
            ||||||||||||||||:.|||..:|.|||||:||||:.||||||||||||||||.||:|||:||:
  Fly  1788 KLRRLMTFAWPCLLSKSSVDPTARYHGHLLLSHIIARLAIHKKIVLQVFHSLLKGHALEARSIVK 1852

Human  1929 QAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLVQHMV 1993
            ||:.:||||:|.|||||:.||||||:||||||||.:.||.|||.||::|:|||:||||.||||::
  Fly  1853 QALDVLTPAMPLRMEDGNTMLTHWTKKIIVEEGHAMQQLFHILQLIIRHYKVYFPVRHQLVQHLI 1917

Human  1994 SAMQRLGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVNSV-SSSIKRGL 2057
            :.||||||.|:.:||.::|||||:||:|||||.||||     |.:..:.|.....: .||:||.
  Fly  1918 NYMQRLGFPPTASIEHKKLAVDLAEVIIKWELHRIKD-----DRETKTDGTEEELIQESSVKRS- 1976

Human  2058 SVDSAQ------EVKRFRTATGAISAVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRVACQVN 2116
            .:|..:      ::.|..|..|.      .|.:.|  |.:| :.|||.:.|||:|||||:|||||
  Fly  1977 GIDLVETRKKSFDIIRETTVQGV------GSHTKP--DDIL-RSIDKSYCDTVLNFLIRLACQVN 2032

Human  2117 DNTNTAGSPGEVLSRRCVNLLKTALRPDMWPKS-ELKLQWFDKLLMTVEQPNQVNYGNICTGLEV 2180
            |......||||.||||||.|||.|:||::||:. ::||.|.||:|.|||.|:. |..|||||::.
  Fly  2033 DPQAPILSPGESLSRRCVMLLKMAMRPEIWPQPFDIKLNWLDKVLATVETPHH-NLNNICTGIDF 2096

Human  2181 LSFLLTVLQSPAILSSFKPLQRGIAACMTCGNTKVLRAVHSLLSRLMSIFPTEPSTSSVASKYEE 2245
            |:||.|:|....::|..:|:|||::.|:...||:::|.:|..|:|:|:|||  |.|.   .|:|:
  Fly  2097 LTFLTTILSPDQLVSIIRPVQRGLSLCIIHQNTRIVRLMHMFLTRIMAIFP--PDTQ---HKHED 2156

Human  2246 LECLYAAVGKVIYEGLTNYEKATNANPSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQKMVRE 2310
            |:.||.||.|:|.|.||:|||:...|.|.|||||||||:..:||.|||||::..|:|.|..:.|:
  Fly  2157 LDLLYTAVSKMIAENLTSYEKSPQPNASSLFGTLMILKACTTNNASYIDRILVQFIRVLNHLTRD 2221

Human  2311 HLNP----QAASGSTEATSGTSELVMLSLELVKTRLAVMSMEMRKNFIQAILTSLIEKSPDAKIL 2371
            |:|.    ...|.|.::.:...||::|||||:|.|:.|||:|:||.||..||.||||||.:.||:
  Fly  2222 HINTIGGNTVISQSPDSNALPLELLVLSLELIKNRIFVMSVEIRKLFIGTILVSLIEKSTEVKII 2286

Human  2372 RAVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDLELNAQFLDLVNYVYRDET 2436
            :.::|:::||:|...|....|.|::||||.||||:|..:||:|.:::|||.|||:::|::||||.
  Fly  2287 KCIIKMLDEWIKTKEPNVMTQVPSIREKSALLVKLMQNVEKKFTDEIELNIQFLEIINFIYRDEI 2351

Human  2437 LSGSELTAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVTCSQNWEAMGNHFWIKQ 2501
            |..:|||.|||.|||:|||...|.:|:||||:.|:||:||:::||||:.|||.|:.:|:|:||||
  Fly  2352 LKQTELTNKLEGAFLNGLRFQNPNVRSKFFEILDSSMRRRLHDRLLYIICSQAWDTIGSHYWIKQ 2416

Human  2502 CIELLLAVCEKSTPIGTSCQGAMLPSITNVI--NLADSHDRAAFAMVTHVKQEPRERENSESKEE 2564
            |||||:........|..|.:...:||||:||  |.:::.:.:..:.::...:.....:..:.|::
  Fly  2417 CIELLILTANTMMQIQCSNEQFKIPSITSVIPVNSSETQENSFVSFLSSHSESFDIIQTVDDKDD 2481

Human  2565 DVEIDIELAPGDQTSTPKTKELSEKDIGNQ---LHMLTNRHDKFLDTLREVKTGALLSAFVQLCH 2626
            ..:||:.   .|:      ||..::.:.|:   |..|..:..:||:..|.::|..:|.|..||||
  Fly  2482 VYDIDLN---ADR------KEDCQQILPNRRVTLVELVYKQAEFLEANRNIRTDQMLVATSQLCH 2537

Human  2627 ISTTLAEKTWVQLFPRLWKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVP 2691
            |.|.||:..|:.:|||:|.|.::.|:..:..|:.|||.||::..|:||.||.||.|||::::|.|
  Fly  2538 IDTQLAQSVWLSMFPRIWSIFTEDQRCNITKELIPFLSSGTNVNQKDCHPSTLNTFVESLTKCAP 2602

Human  2692 PIPIRPCVLKYLGKTHNLWFRSTLMLEHQAFEKGLSLQIK-----PKQTTEFYEQESITPPQQEI 2751
            ||.|.|.:|.||||:||||.|:.|:||..|..:  |:|.|     ..|.::...|:|     ..|
  Fly  2603 PIYIPPNLLAYLGKSHNLWHRAILVLEDMAVNQ--SMQSKDIDGGENQFSDLDVQQS-----NNI 2660

Human  2752 LDSLAELYSLLQEEDMWAGLWQKRCKYSETATAIAYEQHGFFEQAQESYEKAMDKAKKEHERSNA 2816
            .|||:::||.:.|||:|||||.|...|.||..|::|||.||||:||.:|:.||.|.|::......
  Fly  2661 FDSLSKMYSSMHEEDLWAGLWLKFAHYPETNIAVSYEQMGFFEEAQGAYDLAMTKFKQDLSNGVV 2725

Human  2817 SPAIFPEYQLWEDHWIRCSKELNQWEALTEYGQSKGHINPYLVLECAWRVSNWTAMKEALVQVEV 2881
            :..:..|..|||:||:||:||||||:.|.:|.|:....|.:|:||.:|||.:|..||.||.:.|.
  Fly  2726 NTYVNSELLLWENHWMRCAKELNQWDILLDYAQTNKDKNMFLILESSWRVPDWNLMKIALAKTEQ 2790

Human  2882 SCPKEMAWKVNMYRGYLAICHPEEQQLSFIERLVEMASSLAIREWRRLPHVVSHVHTPLLQAAQQ 2946
            ...|...:|:|:|:|||:|.|.||:|...|||.||:||||.||||||||::|||:|.|.|||:||
  Fly  2791 CYLKHYGFKINLYKGYLSILHQEERQTGNIERYVEIASSLCIREWRRLPNIVSHIHLPYLQASQQ 2855

Human  2947 IIELQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSIFMWRQHHYQAIVT 3011
            |:||.||:||:.||..:   |||||||||.:||||||||||:||||||||.||.|||||||.|..
  Fly  2856 IMELHEASQIHQGLAQS---RNNSLHDMKAIVKTWRNRLPIISDDLSHWSDIFTWRQHHYQIITQ 2917

Human  3012 AYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRIHTIPTVPIVDCFQKIR 3076
            ..|..|    ...:.||||||||.|||.:||||||..|..|..:.||||:|||:|||||||||||
  Fly  2918 HLEQQS----DQGSTMLGVHASAQAIISFGKIARKHNLTGVCQETLSRIYTIPSVPIVDCFQKIR 2978

Human  3077 QQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAEFYALKGMFLAQINKSEEANKAFSAA 3141
            ||||||||:....||||..:.|||||||||||||.||.||||||||:.||||.:||||.|:||.|
  Fly  2979 QQVKCYLQMPSTSGKNEINEALEVIESTNLKYFTGEMNAEFYALKGLLLAQIGRSEEAGKSFSVA 3043

Human  3142 VQMHDVLVKAWAMWGDYLENIFVKERQLHLGVSAITCYLHACRHQNESKSRKYLAKVLWLLSFDD 3206
            .|:||.|.|||||||||:|.||:|||::.|.|.|:.|||.|.|:|.|||:|||:|||||.||:|:
  Fly  3044 AQLHDGLTKAWAMWGDYMEQIFLKERKITLAVDALICYLQASRNQIESKTRKYIAKVLWFLSYDN 3108

Human  3207 DKNTLADAVDKYCIGVPPIQWLAWIPQLLTCLVGSEGKLLLNLISQVGRVYPQAVYFPIRTLYLT 3271
            :...|...::|:..|:||..||.||||||.||...||.::|||:||:||:|||||||||||||||
  Fly  3109 NTKILISTLEKHVAGIPPSYWLPWIPQLLCCLEQFEGDVILNLLSQIGRLYPQAVYFPIRTLYLT 3173

Human  3272 LKIEQRERYKSDSGQQQPSSVGN-----------QSH-SASDPGPIRATAPMWRCSRIMHMQREL 3324
            |||||||::|: :.|...||..|           .|| :.....||:||.||||||::|.:|||:
  Fly  3174 LKIEQREKHKT-AEQAVKSSCSNIDGTTLSFGRGASHGNIPSINPIKATPPMWRCSKVMQLQREV 3237

Human  3325 HPTLLSSLEGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKITPHTLNFVKKLV 3389
            |||:||||||||||||||||:|.|||||||:|||.|||::||||...|..:.||||||:|||||.
  Fly  3238 HPTILSSLEGIVDQMVWFRESWTEEVLRQLRQGLIKCYAIAFEKRDTVQHSTITPHTLHFVKKLG 3302

Human  3390 STFGVGLENV--SNVSTMFSSAASESLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLI 3452
            ||||:|:|||  |..|::.:||||||||||||.|.|||||||:|.|||.|||||.||:|||||||
  Fly  3303 STFGIGIENVPGSVTSSISNSAASESLARRAQVTFQDPVFQKMKEQFTNDFDFSKPGAMKLHNLI 3367

Human  3453 SKLKKWIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEFLMPKPTHYYIKIARFMPRV 3517
            ||||.|||:||.|.|:||..||||:|||||||||.:|||||:|||.|:|..:|||::||||||||
  Fly  3368 SKLKTWIKVLETKVKKLPTSFLIEDKCRFLSNFSQKTAEVELPGELLIPLSSHYYVRIARFMPRV 3432

Human  3518 EIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLNPCLEKRKETTKRHLF 3582
            |||||:|||||||||||.|||||||||:.|:.|.::|||||||||.|:||..|||:|||::|.|.
  Fly  3433 EIVQKNNTAARRLYIRGTNGKIYPYLVVLDSGLGDARREERVLQLKRMLNYYLEKQKETSRRFLN 3497

Human  3583 FTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQV 3647
            .||||||.:||||||.||||:|:||::|:|:.|....:::|.||.:|||||:.||||||..:|.:
  Fly  3498 ITVPRVVPISPQMRLAEDNPNSISLLKIFKKCCQSMQVDYDMPIVKYYDRLSEVQARGTPTTHTL 3562

Human  3648 LRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQI 3712
            ||:|..|:|..|||:::||.|||.||..|||:|.||||.|:||||....|..|:|.|||.:|:.:
  Fly  3563 LREIFSEIQWTMVPKTLLKHWALKTFLAATDFWHFRKMLTLQLALAFLCEHALNLTRLNADMMYL 3627

Human  3713 AQDTGKLNVAYFRFDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPN 3777
            .||:|.:|::||:||:||....|:.:||||||||||:.||:|..|::|||:|:::|.||||.|||
  Fly  3628 HQDSGLMNISYFKFDVNDDKCQLNQHRPVPFRLTPNVGEFITHFGITGPLSAAIVATARCFIQPN 3692

Human  3778 FKVDGILKTVLRDEIIAWHKKTQEDTSSPLSAAGQPENMDS---QQLVSLVQKAVTAIMTRLHNL 3839
            :|:..||:|:|||||||..||...:..  |....:....|.   :..|::|..||..||||.:.:
  Fly  3693 YKLSSILQTILRDEIIALQKKGFRECK--LIEGSEDRYSDGNCMEHSVNIVNSAVDIIMTRFNKI 3755

Human  3840 AQFEGGES-KVNTLVAAANSLDNLCRMDPAWHPWL 3873
            :.|:..|: |::.||.:|.::||||||||||||||
  Fly  3756 SYFDSIENKKISVLVQSATNIDNLCRMDPAWHPWL 3790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRRAP	NP_001362453.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..541		7/49 (14%)
		Interaction with TP53. /evidence=ECO:0000269|PubMed:12138177	2017..2395		173/389 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2030..2051		3/21 (14%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	2054..2069		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2550..2585		4/34 (12%)
		TEL1	<2552..3873	CDD:227365	756/1346 (56%)
		FAT	2868..3200	CDD:367004	214/331 (65%)
		PIKK_TRRAP	3510..3797	CDD:270707	175/286 (61%)
Nipped-A	NP_001097192.2	FRB_dom	<2568..3790	CDD:331513	726/1238 (59%)
		FAT	2767..3102	CDD:308074	220/341 (65%)
		PIKK_TRRAP	3425..3712	CDD:270707	175/286 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159482
Domainoid	1	1.000	1991	1.000	Domainoid score	I1
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39246
Inparanoid	1	1.050	3815	1.000	Inparanoid score	I8
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S3127
OMA	1	1.010	-	-		QHG55308
OrthoDB	1	1.010	-	-		D4534at33208
OrthoFinder	1	1.000	-	-		FOG0003313
OrthoInspector	1	1.000	-	-		oto89127
orthoMCL	1	0.900	-	-		OOG6_101815
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.760