Protein Alignment ARID1A and arid1ab

DIOPT Version :10

• Sequence 1: NP_006006.3
• Gene: ARID1A / 8289
• HGNCID: 11110
• Length: 2285
• Species: Homo sapiens
• Sequence 2: XP_021323975.1
• Gene: arid1ab / 568161
• ZFINID: ZDB-GENE-030131-5725
• Length: 2261
• Species: Danio rerio
• Alignment Length: 2436
• Identity: 1487/2436 - (61%)
• Similarity: 1670/2436 - (68%)
• Gaps: 326/2436 - (13%)

Human     1 MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGP 65
            ||||||....|        ||:||||.|::.::|          :..||.:    |||:.|....
Zfish     1 MAAQVATLNTS--------PPAELKKPEREPQDE----------SVIGEKQ----QESKEPRADG 43

Human    66 PQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSD 130
            ..|..|||||||:.....|||||      |.:||:||.|||  |....|||.....||..|.|..
Zfish    44 GSPGQKELQDGADVGNAAGGGGA------GGDPDMKNGNGN--PSRVNNNNSQNDSGGPEGNSHP 100

Human   131 GVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPY 195
            |: ||.|  ..|.|||.|.:.|.|.|:|          || |||||||||:|     |...::||
Zfish   101 GM-APHH--PGAFPPPPYSYNQHYNRAP----------FH-QHGGQQSPGMA-----GPAVMDPY 146

Human   196 AGPQQNSHDHGFPNHQYNSY--YPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKP---PPSS 255
               ..|||:||:||| :|:|  :|||:.| .....|.::|||...|     .|||.:|   ||:.
Zfish   147 ---PPNSHEHGYPNH-FNNYSPFPNRTPY-HQGQGYGMNSPRNSQP-----PAAGGQPGKQPPTG 201

Human   256 SASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGP 320
            ..:..::::|:..||:..           |.||||:|||||||||||||.|.||.||..:|.|
Zfish   202 GTTPLATAASYNNQRYNM-----------GNPQPTSTPTLNQLLTSPSSTRSYQNYPASEYGG-- 253

Human   321 QDGGAGKGPADMASQCWGAAAAAAAAAAASGGA----QQRSHH-APMSPGSSGGGGQPLARTPQP 380
             ..||.|||.||.|            ::..||.    |||||| .|||||::|     .|...||
Zfish   254 -QEGAAKGPGDMGS------------SSQYGGGHPAWQQRSHHPPPMSPGNTG-----QANRTQP 300

Human   381 SSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGL 445
            ..||||:||:|.|.||..||||||||||...|||..||||.||...||||||.||||....:.|:
Zfish   301 PGPMDQVGKIRGQHYGAGNPYSQQQGPPPSSQQGPPYPGQGYGPPGPQRYPMGMQGRTSGNLSGI 365

Human   446 SYTQQIPPYGQQGPSGYGQQGQTPYYNQQ--SPH--------PQQ------QQPPYSQQPPSQTP 494
            .|.||: .|||.||.||| |.|..||.||  |||        |||      .||||||| ||.||
Zfish   366 QYGQQM-GYGQHGPGGYG-QNQAGYYGQQGPSPHGGPQQSSYPQQPSTGPGSQPPYSQQ-PSGTP 427

Human   495 HAQ--PSYQQQPQSQPPQLQSSQPPYSQQP----SQPPHQQSPAPYPSQ-QSTTQQHPQSQPPYS 552
            |.|  .|| .|||. |......||||||.|    .|.|..||..|..|| .|..||..||||.|:
Zfish   428 HGQSGTSY-GQPQG-PHVPNQGQPPYSQTPQSQSGQSPFPQSQGPTQSQGPSQGQQGSQSQPGYT 490

Human   553 QP--------QAQSPYQQQQ--PQQPAPSTLSQQAAYPQPQSQ---QSQQTAYSQ---------- 594
            .|        |.|.|.||||  ||...||     :|.|||..|   |.|.:.|||
Zfish   491 HPPSGSGQPAQQQGPSQQQQGPPQSQTPS-----SAPPQPSQQTSGQGQPSPYSQTPPLQTQQQQ 550

Human   595 --------QRF-PPPQELSQDSFGSQASSAPS----MTSSKGGQEDMNLSLQSRPSSLPDLSGSI 646
                    ||| |||||||||||.|| |||||    :.|||.||:|   ::|.||||||||||||
Zfish   551 QQQQQSPFQRFPPPPQELSQDSFSSQ-SSAPSSNQPIVSSKSGQDD---TMQGRPSSLPDLSGSI 611

Human   647 DDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRS 711
            ||||.||||||||||||||:|||||||||||||||||||||||.|||||||||||||||...||:
Zfish   612 DDLPTGTEGALSPGVSTSGVSSSQGEQSNPAQSPFSPHTSPHLSGIRGPSPSPVGSPASGPASRT 676

Human   712 GPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYSSPQPGSALSPRQP 776
            |||||..:|||||||||.|.|||.::|     ||:.|||.|| |||||| |.|||.||.|||||.
Zfish   677 GPLSPGTMPGNQMPPRPSSVQSDGMLH-----SSMGQDRVYM-RNPQMP-YGSPQSGSTLSPRQT 734

Human   777 SGGQIHTGMGSY-QQNSMGSYGPQGGQYGPQGGYPRQPNYNALPNANYPSA-GMAGGINPMGAGG 839
            ||.|:|.||||| |.||||:||||.|||||| ||||.|.|..:||||||.. ||.|.:|||.
Zfish   735 SGSQMHAGMGSYPQNNSMGNYGPQSGQYGPQ-GYPRPPGYGGMPNANYPGGPGMGGSMNPMA--- 795

Human   840 QMHGQPGIPPYGTLPPGRMSHASMGNRPY----GPNMANMPPQVGSGMCPPPGGMNRKTQETAVA 900
               ||.|..|||.:|||||....||.|||    ||||..|||||.||||||| |||||.|:.|.|
Zfish   796 ---GQGGGGPYGGMPPGRMGPGQMGTRPYGPGMGPNMGGMPPQVASGMCPPP-GMNRKPQDPAAA 856

Human   901 --MHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYSMGGTMANNSAGMAA 963
              .|..:||| :|||||||||| ||||.|.||...:|||.||:|..| .|.|.|.|:|||||||.
Zfish   857 GMHHGPSNSI-HRPPGYPNMNQ-GMMGAGSPYAPPMNSMQGMMNQAG-QYPMPGNMSNNSAGMAP 918

Human   964 SPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYL 1028
            |||   .|..||..:.|:|||.||||||||| ||||||||||||||:|||||.|||||:||||||
Zfish   919 SPE---FGMDKLNQSQKLNNKVDGTPKTESK-KKSSSSTTTNEKITRLYELGPEPERKLWVDRYL 979

Human  1029 AFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLK 1093
            ||.|||||||:||||||||||||:|||||||||||||||||||||||||||||||||||||||||
Zfish   980 AFAEEKAMGMSNLPAVGRKPLDLFRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLK 1044

Human  1094 KQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGG 1158
            |||||||||||||||||||||||.| ..|.||:|.|:||||||||||:|||||||||||||||||
Zfish  1045 KQYIQCLYAFECKIERGEDPPPDFF-NNDPKKNQAKVQPPSPAGSGSLQGPQTPQSTSSSMAEGG 1108

Human  1159 DLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFNDGSDSTFQKRNSMTPNPGYQPSMNTSDMMGR 1223
            ||||||||||||||:||:|| :|| ||.:||.|.||.|..|.:|||:|||.||||.|...|||||
Zfish  1109 DLKPPTPASTPHSQMPPMPG-ARS-SVNLQDPFADGGDPAFSRRNSVTPNSGYQPGMGGPDMMGR 1171

Human  1224 MS-YEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGNVAMGPRQHYPYGGPYDR 1287
            |. :||||||:|.||||  .:.||:.|||||.|||:.|:||:...:||:.||.||.||||..|||
Zfish  1172 MGPFEPNKDPFGGMRKA--GEQFMNPGQGPNSGMGEQYNRASQGPMGNMQMGQRQQYPYGPGYDR 1234

Human  1288 VRTEPGIGPEGNMSTGAPQPNLMPSNPDSGMYSPSRYPPQQQQQQQQRHDSYGNQFSTQGTPSGS 1352
             |.:..:||:|||   .||||:|||..|:|||||:| ||     ||||||||.||::.||.|...
Zfish  1235 -RPDSSMGPDGNM---GPQPNMMPSGADAGMYSPNR-PP-----QQQRHDSYSNQYAGQGAPPSG 1289

Human  1353 PFPSQQTTMYQQQQQNY--KRPMDGTYGPPAKRHEGEMYSVPYSTGQGQPQQQQLPPAQPQPASQ 1415
            |:|:||:.||.|||.||  |||:||.||||||||||:||  |:|   ||.|..|.|.|
Zfish  1290 PYPNQQSGMYPQQQPNYTQKRPVDGVYGPPAKRHEGDMY--PFS---GQQQGPQAPGA------- 1342

Human  1416 QQAAQPSPQQDVYNQYGNAYPATATAATERRPAGGPQNQFPFQFGRDRVSAPPGTNAQQNMPPQM 1480
                 |..|.|:|||| |.||     .:||||. |||:||||.|||||.....|.|:|.:|||||
Zfish  1343 -----PQSQSDMYNQY-NTYP-----GSERRPP-GPQSQFPFGFGRDRGPNVGGPNSQPSMPPQM 1395

Human  1481 MGGPIQA---SAEVAQQGTMWQGRNDMTY-NYANRQSTGSAP-QGPAYHGVNRTDEMLHTDQRAN 1540
            ||..:..   |.....||.||.|||:|.| ||.|||.....| |...|||:||:::|:.:|||.|
Zfish  1396 MGSSMSGTMPSVPDGPQGPMWPGRNEMNYPNYHNRQGPPGVPSQSQVYHGMNRSEDMMPSDQRMN 1460

Human  1541 HEGSWPSH-GTRQPPYGPSAPVPPMTRPPPSNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKS 1604
            .||.||.| ..|||||||.|..|||:||...|||   |.||||||||||||:||||||||||:||
Zfish  1461 QEGPWPGHVNQRQPPYGPVASGPPMSRPLQPNYQ---SSQNHIPQVSSPAPMPRPMENRTSPNKS 1522

Human  1605 PFLHSGMKMQKAGPPVPASHIAPAPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEA 1669
            |::|.|||:|||||||||||||..|||||||||||.|||||:||:||:||.||||||||||||||
Zfish  1523 PYMHPGMKIQKAGPPVPASHIAQPPVQPPMIRRDIAFPPGSIEASQPILKPRRRLTMKDIGTPEA 1587

Human  1670 WRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEY 1734
            ||||||||||||||||||||||||||||||||..|||:||||.|||:||||||||||||||||||
Zfish  1588 WRVMMSLKSGLLAESTWALDTINILLYDDNSISNFNLNQLPGFLELVVEYFRRCLIEIFGILKEY 1652

Human  1735 EVGDPGQRTLLDPGRFSKVSSPAPMEGGEEEEELLGPKLEEEEEEEVVEND-------------E 1786
            ||||||||||:||.......|.   |.|.|.|::   :.::|::||.:||:             |
Zfish  1653 EVGDPGQRTLIDPEAIDPEMSD---EEGPEAEQM---EEDDEDDEEDLENNTVQTSQVQIKQEKE 1711

Human  1787 EIAFSGK--------DKPASENS-------------------EEKLISKFDKLPVKIVQKNDPFV 1824
            |...|.|        |:...:||                   ..|..|||||||:||::|.||||
Zfish  1712 ESMESPKSNDKNELEDREGEDNSCKDHLRSSTPLQDTSASQERPKQASKFDKLPIKIMRKKDPFV 1776

Human  1825 VDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKTELLPSRPHAPCPPAPRKHVT------ 1883
            :..:.||||.|.|||||:||.:||||||||||||||||.|||..|...|....|||.|:
Zfish  1777 IGHTSKLGRRQAFDSGLIHWSVGGGDTTEHIQTHFESKMELLKHRKRVPVNVEPRKKVSQILETV 1841

Human  1884 TAEGTPGTTDQEGP-------PPDGP-----------PEKRITATMDDMLSTRSSTLTEDGAK-S 1929
            |.|.....|: |||       ..|.|           ....||||:||:||.|..:.||:..: :
Zfish  1842 TGEAEKVQTN-EGPQQVQVLASKDQPSLEGKSTTTSSTSTSITATIDDVLSARRGSATEEAVRGN 1905

Human  1930 SEAIKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFV 1994
            .::.||.:.|.|||..||..|||||||||||||||||||||.||||:||:||:||||.:|||||:
Zfish  1906 QDSDKEKNTFLFGIDLAQQSRNIKILEDEPHSKDETPLCTLSDWQDALARRCICVSNIVRSLSFI 1970

Human  1995 PGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCNKVEWWWDCLEMLREN 2059
            ||||.||||||||||:||:|:||||.||||||||:|||||||:|:||||.:.||||||||:||||
Zfish  1971 PGNDLEMSKHPGLLLLLGRLVLLHHWHPERKQAPVTYEKEEEEDEGVSCERDEWWWDCLEVLREN 2035

Human  2060 TLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSK 2124
            .||||||||||||||.||||||||:|||||||||||||||.|||.|||.|..|||||||||||||
Zfish  2036 CLVTLANISGQLDLSIYPESICLPLLDGLLHWAVCPSAEAIDPFPTLGLNGTLSPQRLVLETLSK 2100

Human  2125 LSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQK 2189
            ||||||||||||||||||||||||.::||.:.|||..|||||||||||||||||::|||||||||
Zfish  2101 LSIQDNNVDLILATPPFSRLEKLYGSLVRMVGDRKVTVCREMAVVLLANLAQGDTVAARAIAVQK 2165

Human  2190 GSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLY 2254
            ||:||||||||||||||||||||.||||:|..|||||||||||||||||.|||||:|||||||||
Zfish  2166 GSVGNLLGFLEDSLAATQFQQSQGSLLHLQGSPFEPTSVDMMRRAARALHALAKVEENHSEFTLY 2230

Human  2255 ESRLLDISVSPLMNSLVSQVICDVLFLIGQS 2285
            ||||||||||||||||||.||||||||||||
Zfish  2231 ESRLLDISVSPLMNSLVSHVICDVLFLIGQS 2261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARID1A	NP_006006.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..820		453/888 (51%)
		LXXLL	295..299		3/3 (100%)
		PABP-1234	<372..469	CDD:130689	56/96 (58%)
		PRK07764	<598..729	CDD:236090	108/134 (81%)
		Med15	713..>947	CDD:312941	152/241 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	978..1005		21/26 (81%)
		ARID_ARID1A	1018..1110	CDD:350640	87/91 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1113..1483		226/372 (61%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:26614907	1368..1387		16/20 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1539..1603		45/64 (70%)
		LXXLL	1709..1713		3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1747..1774		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1859..1907		21/71 (30%)
		LXXLL	1967..1971		3/3 (100%)
		BAF250_C	1976..2231	CDD:463439	213/254 (84%)
		LXXLL	2085..2089		3/3 (100%)
arid1ab	XP_021323975.1	Glutenin_hmw	155..774	CDD:367362	369/678 (54%)
		PABP-1234	<352..468	CDD:130689	58/120 (48%)
		ARID	969..1061	CDD:355778	87/91 (96%)
		Med15	1069..>1512	CDD:312941	285/484 (59%)
		BAF250_C	1952..2207	CDD:463439	213/254 (84%)