Protein Alignment EPX and Irc

DIOPT Version :10

• Sequence 1: NP_000493.1
• Gene: EPX / 8288
• HGNCID: 3423
• Length: 715
• Species: Homo sapiens
• Sequence 2: NP_650584.1
• Gene: Irc / 42049
• FlyBaseID: FBgn0038465
• Length: 697
• Species: Drosophila melanogaster
• Alignment Length: 736
• Identity: 184/736 - (25%)
• Similarity: 298/736 - (40%)
• Gaps: 132/736 - (17%)

Human    25 PASPGA--VETSVLRDCIAEAKLLVDAAYNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVV 87
            |||...  |||::  |.:...|.|.|   |.....|  .:::||.|...||...  |..|::...
  Fly    38 PASKWLQYVETAL--DSVNRQKRLED---NLLGSDI--TVKNGSLSHAQLLDTL--PSLASKKDN 93

Human    88 RAADYMHVALGLLEEKLQPQRSG--PFNVTDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITG 150
            :      :||.:|:..|....|.  |.|:........|.......|.:||.:.|      .::.|
  Fly    94 K------LALKILKSSLLVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLRTECE------NSLKG 146

Human   151 RCNNKR-----RPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFP 210
               |:.     |.|||:|:          |.:|....|  ..|.||.  .:|...::|.::.. |
  Fly   147 ---NREGHYAFRRLLGSSH----------YRNGFYQMF--PNSGRRE--TVPAAWSISKELYE-P 193

Human   211 -----NERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVD---CERTCAQL------P 261
                 :::.|.:....|...||.||::|||    ..|...:.:.|..   |.|....|      |
  Fly   194 DHIQISKQQTFESNSNLALPQWAQFVEHDL----SKPVSQSMSNGAPIECCSRDQINLQPRHHHP 254

Human   262 PCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLR 326
            .|.||...|...  .:...|:.:.|||.:..........|:|..|..:|.|.:||...:...:||
  Fly   255 ACAPILYQPGGK--YDVPSCLNYVRSALAVADCNFGGAEQLNQATGSLDLSQLYGFTAAAERKLR 317

Human   327 NRTNYLGLLAINQRFQ-DNGRALLPFDNLHDDPCLLTNRSARI---PCFLAGDTRSTETPKLAAM 387
            ....  |||....|.: ||  ||||.....:.|.....  |.|   .||.|||:|...:|....:
  Fly   318 VLEG--GLLRSTPRGEFDN--ALLPIATDTEGPSFCAR--ATIGDGTCFAAGDSRVNSSPFSILI 376

Human   388 HTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGHYR 452
            :|:|||.||::|.||::.||||:.:||:..|:.:...:.:.:...::||.|||    ::.....|
  Fly   377 YTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLG----QKMSSEIR 437

Human   453 GYCSNVDPRVANVFTL-AFRFGHTMLQPFMFRLDSQ---YRASAPNSHVPLSSA-----FFASWR 508
            ....|....|:|.|.: |.||..:||...:..|...   |.....|.:|.:|..     .|....
  Fly   438 RKQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKE 502

Human   509 IVYEGGIDPILRGLMATPAKLN-------RQDAMLVDELRDR---LFRQVRRIGLDLAALNMQRS 563
            .:|:       ..|..|..|||       .|:.|.:|.....   ..:..:....|:.|.::||.
  Fly   503 EIYK-------PKLQYTSQKLNNILESLLNQETMKMDAAYSGGVVWHKDTKPTHADILAFDIQRG 560

Human   564 RDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGAR 628
            |||||..|..:...|.||:|....:........|:..|...:|.:..::|:.:|.|:|..:.|:
  Fly   561 RDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVLDKLKTIYASWADVDLIVGGISENPVHGS- 624

Human   629 VGPLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSR----------ISLSRIICDNTGITT 683
            :||..:|:...||..             |..:.|:||:.:          .:.::::|.|:|::.
  Fly   625 IGPTFSCIISEQFVH-------------VLKQNQQKAVQKHTELVEQYRHFNGTKLLCLNSGLSA 676

Human   684 VSRDIFRANIYPRGFVNCSRI 704
            |.::||:........|:|..:
  Fly   677 VPQNIFQLPSARNQMVSCEDV 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPX	NP_000493.1	myeloperoxidase_like	289..699	CDD:188656	112/442 (25%)
Irc	NP_650584.1	An_peroxidase	151..682	CDD:460804	147/582 (25%)