DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIN2 and hrd1

DIOPT Version :9

Sequence 1:	NP_001328533.1	Gene:	RIN2 / 828626	AraportID:	AT4G25230	Length:	578	Species:	Arabidopsis thaliana
Sequence 2:	NP_596376.1	Gene:	hrd1 / 2539900	PomBaseID:	SPBC17D11.02c	Length:	677	Species:	Schizosaccharomyces pombe

Alignment Length:	642	Identity:	137/642 - (21%)
Similarity:	228/642 - (35%)	Gaps:	205/642 - (31%)

- Green bases have known domain annotations that are detailed below.

plant    57 YFTIALLTNFVLNVYILLVLSLKTLFFGDLYDVETKKLVERLANYIIYKGTFLPLVIPPTIFQGV 121
            :.||.|  |..|.::..:..:||||.||.|...|.:.|.|:.  :|    |...:::..|:|:..
pombe    41 HITIGL--NVCLCLFFAIANALKTLLFGSLQTFELELLYEQF--WI----TLTEIMLAITVFREA 97

plant   122 LWTVWLTVLCTL---KMFQALARDRLERLNASPSSTPWTYFRVYSVLFLVLSVDMFWIKLSLMTY 183
            :...:..:|.||   ::|.::...|.|||....:...:..|...:..:.|||:
pombe    98 ISISFFMLLSTLMFARVFHSICSFRTERLQIQLTDQRFHIFSRLTCAYFVLSI------------ 150

plant   184 NTIGSAVYLLLLFEPCSIAFETLQALLIHGFQLLDMWINHLAVKNSDCQRSKFIDSMTAGSLLEW 248
             ...|.:||....|                         ||..|::   |..|:        .|:
pombe   151 -LDASLIYLCFTSE-------------------------HLGDKST---RMLFV--------CEF 178

plant   249 KGLLNRNLGFFLDMATLVMAL---GHYLHIW---------------WLHGIAFHLV-------DA 288
            ..||   |...::.:.|.:.|   .|...:|               .|..:|:.|:       .:
pombe   179 SVLL---LNLTIEASKLCIYLYEARHLDQVWDEKSTYLFRLEVCRDGLRLLAYSLLFMYQFPYVS 240

plant   289 VLFLNIRALLS---AILKRIKGYIKLRIALGALHAALPDATSEELRAYDDECAICREPM------ 344
            |...:||.:.:   ::.:||:.:.:.|.|...::|..|.||.|:|...|..|.||||.|
pombe   241 VPIYSIRQMYTCFYSLFRRIREHARFRQATRDMNAMYPTATEEQLTNSDRTCTICREEMFHPDHP 305

plant   345 ---------------AKAKRLHCNHLFHLGCLRSWLDQGLNEVYSCPTCRKPLFVGRTENEVNPR 394
                           ...|||.|.|:.|..|||:||::    ..:||.||:.: :|   |:.:|.
pombe   306 PENTDEMEPLPRGLDMTPKRLPCGHILHFHCLRNWLER----QQTCPICRRSV-IG---NQSSPT 362

plant   395 TVEVSSD---EQLARQLER-QNNPVHALATGL------------------------FPAEVPDSV 431
            .:..|.:   .|:|.|:.. ||.|......|:                        |.|...| :
pombe   363 GIPASPNVRATQIATQVPNPQNTPTTTAVPGITNSSNQGDPQASTFNGVPNANSSGFAAHTQD-L 426

plant   432 ENDTSRNLGLDPSW----------LQTWSSQGSDVAGPSTTSRT--------------VGLGRVQ 472
            .:...|.:.|...|          :.|: ||.:....||.|..|              ...|...
pombe   427 SSVIPRRIALRDGWTMLPIPGTRRIPTY-SQSTSTTNPSATPTTGDPSNSTYGGPQTFPNSGNNP 490

plant   473 MMMRHLASV-------GESYAQTALDDAAWSLWPMNPSQA----STSSTTVPPGNGGRTGGLHLR 526
            ...|.:|.:       ..|..|:...::|.:....|.|.|    .:|...|.|.:.|.|   ...
pombe   491 NFNRGIAGIVPPGWRLVSSNTQSLSTNSAMTSLYQNASSADNNLGSSLPNVVPLSRGLT---QSN 552

plant   527 TVSNTTNESLTNILAMAETVREVMPHVPDEIIFQDLQRT--------NSVAVTVNNL 575
            ..|||...:.:||   :..:||:...:      .:|:.|        ||:..::|.|
pombe   553 ETSNTFPAASSNI---SSQLRELHTKI------DELRETVSNFRADYNSIRTSLNQL 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIN2	NP_001328533.1	None
hrd1	NP_596376.1	HRD1	1..514	CDD:227568	115/542 (21%)
hrd1	NP_596376.1	zf-RING_2	291..351	CDD:290367	19/63 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810