DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIN2 and Amfr

DIOPT Version :9

Sequence 1:	NP_001328533.1	Gene:	RIN2 / 828626	AraportID:	AT4G25230	Length:	578	Species:	Arabidopsis thaliana
Sequence 2:	NP_035917.2	Gene:	Amfr / 23802	MGIID:	1345634	Length:	639	Species:	Mus musculus

Alignment Length:	560	Identity:	139/560 - (24%)
Similarity:	227/560 - (40%)	Gaps:	138/560 - (24%)

- Green bases have known domain annotations that are detailed below.

plant    30 RLRADGLIAKNISLGDSEHALELLLGSYFTIALLTNFVLNVYILLVLSLKTLFFGDLYDVETKKL 94
            ||.|.|..|::::        :.||.....:.:|.|....|.:|:...::.:.||.|...|.:.|
Mouse    58 RLTAGGPRARDVA--------QYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHL 114

plant    95 VERLANYIIYKGTFLPLVI-PPTIFQGVLWTVWLTVLCTLKMFQALARDRLERLNASPSSTPWTY 158
            .::..|:|.||..|:..|: ..|:.:.|:|.:|...|..|.:...|.:||.|.|:.||::...::
Mouse   115 KDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSH 179

plant   159 FRVYSVLFLVLSVDMFWIKLSLMTYNTIGSAVYLLLLFEPCSIAFETLQALLIHGFQLLDMWINH 223
            .||.|:|..:|........:..:|..|.|......:..|...:...|...:|.:...|.|  :||
Mouse   180 GRVLSLLIAMLLSCCGLAVVCCVTGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWD--LNH 242

plant   224 LAVKNSDCQRSKFIDSMTAGSLLEWKGLLNRNLGFFLDMATLVMALGHYLHIWWLHGIAFHLVDA 288
                               ....|.||.......|.:::|.|.:.|.|::|:.....|...:...
Mouse   243 -------------------EGTWEGKGTYVYYTDFVMELALLSLDLMHHIHMLLFGNIWLSMASL 288

plant   289 VLFLNIRALLSAILKRI---KGYIKLRIALGALHAALPDATSEELRAYDDECAICREPMAKAKRL 350
            |:|:.:|.|...:.:||   |.|:::   :|.:.|....||.|||...:|:||||.:.|..|::|
Mouse   289 VIFMQLRYLFHEVQRRIRRHKNYLRV---VGNMEARFAVATPEELAVNNDDCAICWDSMQAARKL 350

plant   351 HCNHLFHLGCLRSWLDQGLNEVYSCPTCRKPLFV-----GRTENE---VNPRTVEVSSDEQLARQ 407
            .|.||||..||||||:|..    ||||||..|.:     .|.:::   ::...|.|::.|...|
Mouse   351 PCGHLFHNSCLRSWLEQDT----SCPTCRMSLNIADGSRAREDHQGENLDENLVPVAAAEGRPR- 410

plant   408 LERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQ 472
            |.:.|:..|.                |.||    ..|||.::|                    |:
Mouse   411 LNQHNHFFHF----------------DGSR----IASWLPSFS--------------------VE 435

plant   473 MMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLT 537
            :|                                                 |...:...|..|.:
Mouse   436 VM-------------------------------------------------HTTNILGITQASNS 451

plant   538 NILAMAETVREVMPHVPDEIIFQDLQRTNSVAVTVNNLLQ 577
            .:.|||..::|:.|.||..::.||||.|.||.:|.:|:|:
Mouse   452 QLNAMAHQIQEMFPQVPYHLVLQDLQMTRSVEITTDNILE 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIN2	NP_001328533.1	None
Amfr	NP_035917.2	HRD1	82..>378	CDD:227568	94/323 (29%)
		zf-RING_2	335..375	CDD:290367	24/43 (56%)
		CUE_AMFR	454..494	CDD:270604	17/38 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..531
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620
		VCP/p97-interacting motif (VIM). /evidence=ECO:0000250\|UniProtKB:Q9UKV5	618..636
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I1819
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105132
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3836
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.760