Protein Alignment KDM5D and kdm5c

DIOPT Version :10

• Sequence 1: NP_001140177.1
• Gene: KDM5D / 8284
• HGNCID: 11115
• Length: 1570
• Species: Homo sapiens
• Sequence 2: NP_001072719.1
• Gene: kdm5c / 780176
• XenbaseID: XB-GENE-1033025
• Length: 1506
• Species: Xenopus tropicalis
• Alignment Length: 1557
• Identity: 1010/1557 - (64%)
• Similarity: 1193/1557 - (76%)
• Gaps: 108/1557 - (6%)

Human     6 DEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRVQ 70
            ::|:||.|||||||:|.||:||||||||||||||||||||||||.|||||||||||||.||||:|
 Frog     7 EDFVPPAECPVFEPTWEEFKDPLGYIAKIRPIAEKSGICKIRPPVDWQPPFAVEVDNFHFTPRIQ 71

Human    71 RLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICKDRRWA 135
            |||||||:|||||||||||||||||||||||||||||:|||||||:|||.||||||.||::||||
 Frog    72 RLNELEAETRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLNKIVQEEGGYEPICRERRWA 136

Human   136 RVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHP-FDNEVKDKEYKPHSIPLRQ 199
            |||||:.||.|||:||||||||||||||:.|:|||||.|.....| :|||.||||||||||||||
 Frog   137 RVAQRMGYPSGKNLGSLLRSHYERIIYPFHMYQSGANMVDYRERPRYDNEEKDKEYKPHSIPLRQ 201

Human   200 SVQPSKFSSYSRRAKRL----------------QPD------PEPTEEDIEKHPELKKLQIYGPG 242
            ||||||.:||.||||||                ||.      ||||.|||||:||||||||||.|
 Frog   202 SVQPSKITSYGRRAKRLTQEDPENSDPAAQSSSQPTETSPSWPEPTVEDIEKNPELKKLQIYGAG 266

Human   243 PKMMGLGLMAKDKDKTVHKKVT----CPPTVTVKDEQSGGGNVSSTLLKQH------LSLEPCTK 297
            |||||||||||:|:  :.||.:    ||||:.:|:|....|......::.|      ||.|||||
 Frog   267 PKMMGLGLMAKNKN--LRKKDSDIPECPPTLVIKEEVPVEGRGEPGEVQVHVKQERSLSPEPCTK 329

Human   298 TTMQLRKN--HSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPK 360
            .||:||:|  .:|.||:|||||::|||||:||:||.|||||||||.|||||||||.|:|||.|||
 Frog   330 MTMRLRRNTITNSNQFVDSYICRICSRGDDDDRLLLCDGCDDNYHTFCLLPPLPEPPKGIWHCPK 394

Human   361 CILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEED 425
            |::||||:|||||||||||:|::|||||||||:||:|||||||||||||||||||||||:|||||
 Frog   395 CVMAECKRPPEAFGFEQATREFTLQSFGEMADAFKADYFNMPVHMVPTELVEKEFWRLVNSIEED 459

Human   426 VTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKRQSLTVLTRLISSFWAQAVLPPWPPKVLGLQEY 490
            |||:|||||||||||||||:.:.|..||||||                               .|
 Frog   460 VTVQYGADIHSKEFGSGFPMLDGKTELSPEEK-------------------------------AY 493

Human   491 ATSGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTW 555
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   494 ATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTW 558

Human   556 YGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPR 620
            |||||.|||.||:|||.||||||:|||||||||||||||||||:|||||||||||||||||||||
 Frog   559 YGVPSSAAEQLEDVMKKLTPELFESQPDLLHQLVTLMNPNTLMAHGVPVVRTNQCAGEFVITFPR 623

Human   621 AYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAV 685
            ||||||||||||||||||||||||||||:|||||||||||||||||||||||||.||.||::||.
 Frog   624 AYHSGFNQGYNFAEAVNFCTADWLPAGRKCIEHYRRLRRYCVFSHEELICKMAACPERLDMSLAA 688

Human   686 AVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLV 750
            |||||||::|||||||||.|||:||||||||||||||||||||.|||||||||||||||||.|||
 Frog   689 AVHKEMFLLVQEERRLRKTLLEQGVTEAEREAFELLPDDERQCQKCKTTCFLSALACYDCPQGLV 753

Human   751 CLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEEL 815
            ||.||.|||:|..|||||||||||||||.||||||.||||||||:||||:|:|::...|:...||
 Frog   754 CLYHIEDLCQCPPSRQYLRYRYTLDELPAMLHKLKGRAESFDTWSNKVRLAIELDGKTKKELVEL 818

Human   816 RALESEARERRFPNSELLQRLKNCLSEVEACIAQ---VLGLVSGQVARMDTPQLTLTELRVLLEQ 877
            :.||:||.|::|..:|.||.|:..:.|||:|||:   |||.  .|..|..:..::|..|..|:::
 Frog   819 KTLEAEAFEKKFVENEHLQLLRGSIQEVESCIAEAKKVLGF--SQANRSHSTVISLEGLIKLVKR 881

Human   878 MGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQQ 942
            :.|:||.:.|:..::.:.|:.|..|.||:::|.||.:|...||.:|||.|.|.||||...|:::.
 Frog   882 IQSVPCVVPQLSQLQCLQEEAETLQEEAQKSLLTLSNSTSQLREVLERCQALTVEVPAVRQIERH 946

Human   943 VEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAELQELLTIAERWEEKAHF 1007
            :.|.:||:.|:.||: |...|:|..|:.||....::|.||:|:|||:|||||::||.||||||..
 Frog   947 LRQGEWLERVRTALS-SGRSGTLQEMRSLLKEAEEVAESPAVEKARSELQELISIALRWEEKAQM 1010

Human  1008 CLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGL 1072
            |||||:|||||.|||||:|.|:|||.|||..:|||||.||:||.|||:|||:|||||||||||||
 Frog  1011 CLEARKKHPPAMLEAIIKEAEHIPVQLPNTLSLKEALCKARAWSADVEEIQSGDHYPCLDDLEGL 1075

Human  1073 VAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRW- 1136
            |||||||||.:|||.|||:||..|||||||||||||||||||||||||||.||..||:.|||||
 Frog  1076 VAVGRDLPVKMEELHQLEVQVAAAHSWREKASKTFLKKNSCYTLLEVLCPSADVCSDTGKRSRWK 1140

Human  1137 MEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASS 1201
            .||..|||:.|.|.||||||||||||.:::||||||||||.|||:||..||        ||...
 Frog  1141 KEKEQGLYRSDIESLGLSAQDLRDPGCIVLAFKEGEQKEKAGILRLRAMNS--------SLERG- 1196

Human  1202 PTSICVCGQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCM 1266
              .:||||:.|..: :|:|:||||.|||.||..|.|  |......:.|.|.|||||::|||.||:
 Frog  1197 --CVCVCGEPPDEL-MLRCELCQDLFHGLCVPSPRL--SNHRGAHTMPSLIWWEWDSRFLCSLCV 1256

Human  1267 RSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQ 1331
            |||||||:|||:||||||:||||||||||||||||||:.||||||:.||:.::::....|||.||
 Frog  1257 RSRRPRLQTILSLLVALQKLPVRLPEGEALQCLTERAMSWQDRARRVLATPEISSAATALAERRQ 1321

Human  1332 QLQAKPRPEEASVYTSATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLL 1396
            ::|...:..:|...|:....:|:.:             ||||..|.....|.   .||:.:::||
 Frog  1322 KMQQHCKDPQALRETTRNEQNPVPQ-------------ENGDCHTENGTCAM---PDLDAMAALL 1370

Human  1397 PQL-TGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEH 1460
            |:| ...:|||....||.||:||:|||||||:|:|..|||:||.|.|.|.::|:|||:|:|:.|.
 Frog  1371 PRLEKTAILELSLGSRALLEDLMLEGDLLEVSLEEEASIWRLLLASQVPCIERLRTLIEIERCER 1435

Human  1461 QGSRTRSRALE-RRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRE 1521
            :.:|.:.:..| |::||.:...|.:...|.::||..||.||. |.:|....::....|...|
 Frog  1436 RLARQKGKDPEKRKKRRSERGDGYSPPILPKEELGPKRCRSD-IRAQETLSDKESPRKGGSE 1496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM5D	NP_001140177.1	JmjN	13..54	CDD:128818	36/40 (90%)
		ARID_KDM5C_5D	79..170	CDD:350639	77/90 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	192..228		30/57 (53%)
		PHD1_KDM5C_5D	316..361	CDD:277077	35/44 (80%)
		JmjC	522..638	CDD:396791	109/115 (95%)
		zf-C5HC2	728..780	CDD:460750	44/51 (86%)
		PLU-1	793..1118	CDD:462475	181/327 (55%)
		PHD2_KDM5C_5D	1205..1265	CDD:277081	29/59 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1460..1552		17/63 (27%)
kdm5c	NP_001072719.1	JmjN	14..55	CDD:128818	36/40 (90%)
		ARID_KDM5C_5D	80..171	CDD:350639	77/90 (86%)
		PHD_SF	350..395	CDD:473978	35/44 (80%)
		JmjC	525..641	CDD:396791	109/115 (95%)
		zf-C5HC2	731..783	CDD:460750	44/51 (86%)
		PLU-1	796..1121	CDD:462475	181/327 (55%)
		PHD2_KDM5C_5D	1198..1255	CDD:277081	29/59 (49%)