Protein Alignment KDM5D and kdm5c

DIOPT Version :10

• Sequence 1: NP_001140177.1
• Gene: KDM5D / 8284
• HGNCID: 11115
• Length: 1570
• Species: Homo sapiens
• Sequence 2: NP_001116706.1
• Gene: kdm5c / 553406
• ZFINID: ZDB-GENE-060810-94
• Length: 1578
• Species: Danio rerio
• Alignment Length: 1599
• Identity: 947/1599 - (59%)
• Similarity: 1152/1599 - (72%)
• Gaps: 174/1599 - (10%)

Human     1 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRF 65
            |:.| :||:||||||||||||.||.||||||||||||||||||||||||.|||||||||||||.|
Zfish     2 MDVG-EEFVPPPECPVFEPSWEEFADPLGYIAKIRPIAEKSGICKIRPPPDWQPPFAVEVDNFHF 65

Human    66 TPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICK 130
            |||:||||||||:|||||||||:||||||||||||||||:||:||||:||:|||.||||:|::.|
Zfish    66 TPRIQRLNELEAETRVKLNYLDRIAKFWEIQGSSLKIPNLERRILDLFSLAKIVTEEGGFESVSK 130

Human   131 DRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSI 195
            :||||||||:|.||||||||||||||||||:||:|:|||||:........:|::..|:|||||||
Zfish   131 ERRWARVAQKLGYPPGKNIGSLLRSHYERIVYPFELFQSGASLPPRKPRQYDSDEVDREYKPHSI 195

Human   196 PLRQSVQPSKFSSYSRRAKRLQPD-------------------PEPTEEDIEKHPELKKLQIYGP 241
            ||||||.|||.|||.|||.||||:                   ||||||||||:||||||||||.
Zfish   196 PLRQSVPPSKMSSYGRRANRLQPEGPEDPTHHPLTTGSQHISSPEPTEEDIEKNPELKKLQIYGA 260

Human   242 GPKMMGLGLMAKDKDKTVHKKVTCPPTV-----TVKDEQSGGGNVSS---------TLL------ 286
            |||||||||:.:||.:   ||...|.||     .||||.:......|         .|:
Zfish   261 GPKMMGLGLVPRDKTR---KKDDLPQTVIVRDSAVKDEPAETAVTKSDPDIPPPPPNLIIKEDVD 322

Human   287 --KQHL------SLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFC 343
              |.|:      |.|||||.||:||:|.::.||:||::|::|.|||||:||:.|||||||||.||
Zfish   323 DDKSHIDKPNDPSDEPCTKMTMRLRRNLNNPQFVDSFVCRMCGRGDEDEKLMLCDGCDDNYHTFC 387

Human   344 LLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPT 408
            |:|||.:.|:|.||||||:..|||:|.|||||||||:||:|||||||||:||:||||||||||||
Zfish   388 LIPPLTDPPKGNWRCPKCVAEECKKPSEAFGFEQATREYTLQSFGEMADTFKADYFNMPVHMVPT 452

Human   409 ELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKRQSLTVLTRLISSFWA 473
            |||||||||||||||||||||||||||||||||||||:|.|:.||.||
Zfish   453 ELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVNNGKRQLSEEE----------------- 500

Human   474 QAVLPPWPPKVLGLQEYATSGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIED 538
                          :|||.|||||||||||:||:|||||||||||||||||||||||||||||||
Zfish   501 --------------EEYARSGWNLNVMPVLEQSLLCHINADISGMKVPWLYVGMVFSAFCWHIED 551

Human   539 HWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVP 603
            |||||||||||||||||||||..|||.||||||.||||||:.||||||||||:||||.|||||||
Zfish   552 HWSYSINYLHWGEPKTWYGVPCSAAEKLEEVMKKLTPELFEFQPDLLHQLVTIMNPNILMSHGVP 616

Human   604 VVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEEL 668
            ||||||||||||||||||||||||||||||||||||||||||.||.||||||:||||||||.|||
Zfish   617 VVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPTGRSCIEHYRQLRRYCVFSQEEL 681

Human   669 ICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKT 733
            .|||||.||.||||||.|.|:||||:|||||:|||:|||:|:.|||||||||||||||||.||||
Zfish   682 TCKMAACPEKLDLNLAAATHREMFIIVQEERKLRKSLLERGIKEAEREAFELLPDDERQCDKCKT 746

Human   734 TCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKV 798
            |||||||||.:||:.||||.|..|||.|.|.:.|||||||||||..|||:||:||||||:|||:|
Zfish   747 TCFLSALACSNCPERLVCLYHAQDLCSCPSEKLYLRYRYTLDELLAMLHRLKVRAESFDSWANRV 811

Human   799 RVALEVEDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVS-GQVARMD 862
            :.|||.::|.|...::|..|:.||.:::|||:||||||.....::|.|.:....|:| .|.:||
Zfish   812 KEALEQDEGNKIDIKDLEVLKEEAADKKFPNNELLQRLNTVFVDIEKCESCSTELLSNSQSSRM- 875

Human   863 TPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPS-----SP----GL 918
                ||.||:.|::.|.:|||.:.|..:|:.:|:::|.:.:.|:..:.:..|     ||    ..
Zfish   876 ----TLKELKTLVDTMQNLPCVIKQQDEVQLILQKIEEFDSRAQVLVDSTKSEWKQDSPLPVATE 936

Human   919 LRSLLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPS 983
            :::|||.|..|.|..|....|...:||.:||.||::.|.|.....:|.:::.|:..|..:..|.|
Zfish   937 IQALLEEGASLPVIAPACELLSGLLEQGRWLGEVRRTLGPEGSEVTLTVLRNLMESGCNVPQSVS 1001

Human   984 VDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQ 1048
            |:.|.|||||||||||||||||..|||.||||..:|||||:.|.:.|||.||||.:|:..|::|:
Zfish  1002 VETAMAELQELLTIAERWEEKAQICLEDRQKHHLSTLEAIVNEAQLIPVQLPNILSLQACLSRAR 1066

Human  1049 AWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSC 1113
            ||:.|::|||||:|||||||||||||:||||||.:|||:||||||.:|||||||||||||||||.
Zfish  1067 AWVTDLEEIQNGEHYPCLDDLEGLVAIGRDLPVKMEELKQLELQVASAHSWREKASKTFLKKNSQ 1131

Human  1114 YTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTE--LLGLSAQDLRDPGSVIVAFKEGEQKEK 1176
            ::||||||||.:       :|:.||....:.:.|::  :|||:||||||||::::||||||:.||
Zfish  1132 HSLLEVLCPCVE-------KSKKMEDNSMVTEADSDVNVLGLTAQDLRDPGAIVMAFKEGERLEK 1189

Human  1177 EGILQLRRTNSAKPS--------------------------PL---APSL--------MASSPTS 1204
            |.:|:|::.|.||||                          ||   :|.|        :.||.|
Zfish  1190 EALLRLQQVNLAKPSIENGVSTDQDSIKTEKKQSNSMETDVPLNSDSPVLQNGGSSHSLTSSQT- 1253

Human  1205 ICVCGQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSR 1269
            :|:||..|..: :.:|.||:|||||.|||.|.||.:....||..  |.||:|:|:||||.|.|||
Zfish  1254 VCICGGPPRPL-LHRCHLCKDWFHGGCVSFPPLLATSDTHLTKP--LCWWDWNTRFLCPRCQRSR 1315

Human  1270 RPRLETILALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQ 1334
            |||||||||||||||||||||||||||||||||||.||.||::||.:.:|...|.:|.::..::.
Zfish  1316 RPRLETILALLVALQRLPVRLPEGEALQCLTERAINWQGRAKQALDTPEVQEALDRLQQVEDEMV 1380

Human  1335 A--KPRPEEASVYT---------SATACDPI----------REGSGNNISKVQGLLENGDSVTSP 1378
            :  :..|||...:.         |..|.|.:          ::...|.::..|...|||....|.
Zfish  1381 SIKEEEPEEKKKWNGDAVIVLSDSEEAEDGVIDLTEDGNSPKKNERNAVNGTQSGCENGIGRKSS 1445

Human  1379 ENMAPGKGSDLELLSSLLPQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQP 1443
            .:...|    :|.|.||:|.|.|||:||..::||.||||.:||||||||||:.|:|:::|||...
Zfish  1446 AHEVTG----VESLLSLVPSLKGPVVELNTSVRAQLEELQLEGDLLEVTLDQTHAIYRILQASSQ 1506

Human  1444 PDLDRIRTLLELEKFEHQ--GSRTRSRALERRRRRQKVD 1480
            |..|.:|||:::|..|.:  |...:|:..:|:|:.||.:
Zfish  1507 PPQDTLRTLIQIELQEQRSSGRGNKSKDSKRKRKSQKTE 1545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM5D	NP_001140177.1	JmjN	13..54	CDD:128818	37/40 (93%)
		ARID_KDM5C_5D	79..170	CDD:350639	74/90 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	192..228		30/54 (56%)
		PHD1_KDM5C_5D	316..361	CDD:277077	30/44 (68%)
		JmjC	522..638	CDD:396791	107/115 (93%)
		zf-C5HC2	728..780	CDD:460750	37/51 (73%)
		PLU-1	793..1118	CDD:462475	163/334 (49%)
		PHD2_KDM5C_5D	1205..1265	CDD:277081	29/59 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1460..1552		6/23 (26%)
kdm5c	NP_001116706.1	JmjN	13..54	CDD:128818	37/40 (93%)
		ARID_KDM5C_5D	79..170	CDD:350639	74/90 (82%)
		PHD1_KDM5C_5D	360..405	CDD:277077	30/44 (68%)
		JmjC	535..651	CDD:396791	107/115 (93%)
		zf-C5HC2	741..793	CDD:460750	37/51 (73%)
		PLU-1	806..1136	CDD:462475	163/334 (49%)
		PHD2_KDM5C_5D	1254..1311	CDD:277081	29/59 (49%)