Protein Alignment KDM5D and Kdm5d

DIOPT Version :10

• Sequence 1: NP_001140177.1
• Gene: KDM5D / 8284
• HGNCID: 11115
• Length: 1570
• Species: Homo sapiens
• Sequence 2: NP_035549.1
• Gene: Kdm5d / 20592
• MGIID: 99780
• Length: 1548
• Species: Mus musculus
• Alignment Length: 1586
• Identity: 1245/1586 - (78%)
• Similarity: 1365/1586 - (86%)
• Gaps: 54/1586 - (3%)

Human     1 MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRF 65
            |:||.|:|||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse     1 MKPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRF 65

Human    66 TPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICK 130
            |||:||||||||||||||||||||||||||||||||||||||||||||||:|||:||||||||||
Mouse    66 TPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLNKIVMEEGGYEAICK 130

Human   131 DRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSI 195
            |||||||||||:||.||||||||||||||||||||:||||||.|||||.|||:|.:|||||||||
Mouse   131 DRRWARVAQRLNYPSGKNIGSLLRSHYERIIYPYEIFQSGANLVQCNTDPFDSEERDKEYKPHSI 195

Human   196 PLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVH 260
            ||||||||||||.||||.|||||:||||||||||:||||||||||.||||:||||  |.|:||:.
Mouse   196 PLRQSVQPSKFSCYSRRGKRLQPEPEPTEEDIEKNPELKKLQIYGAGPKMIGLGL--KAKEKTLR 258

Human   261 KK---------VTCPPTVTVKDEQSGGGNVSSTLLKQHL--SLEPCTKTTMQLRKNHSSAQFIDS 314
            ||         ||||.|:.||.|.|..|.|:|....::|  |.|||.|.|||||.||||.||::|
Mouse   259 KKDSKQPDKEEVTCPATIVVKGEASEFGKVTSAFSDKNLNHSFEPCMKMTMQLRNNHSSTQFMNS 323

Human   315 YICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQAT 379
            |:|::||||||.||.|.||||.||||||||||||.|:|:|:||||||||||||.|||||||||||
Mouse   324 YVCRICSRGDEVDKFLLCDGCSDNYHIFCLLPPLSEVPKGVWRCPKCILAECKSPPEAFGFEQAT 388

Human   380 QEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFP 444
            |||:||||||||||||:|||||||||||||:||||||||||||||||||||||||||||||||||
Mouse   389 QEYTLQSFGEMADSFKADYFNMPVHMVPTEVVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFP 453

Human   445 VSNSKQNLSPEEKRQSLTVLTRLISSFWAQAVLPPWPPKVLGLQEYATSGWNLNVMPVLDQSVLC 509
            |:|||.:||||||                               |||..||||||||||||||||
Mouse   454 VNNSKWDLSPEEK-------------------------------EYAACGWNLNVMPVLDQSVLC 487

Human   510 HINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLT 574
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||.||
Mouse   488 HINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEDVMKRLT 552

Human   575 PELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFC 639
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   553 PELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFC 617

Human   640 TADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKA 704
            ||||||.|||||||||||||||||||||||||||||||.|||||||||||||||||||||||||.
Mouse   618 TADWLPVGRQCIEHYRRLRRYCVFSHEELICKMAAFPEKLDLNLAVAVHKEMFIMVQEERRLRKT 682

Human   705 LLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLR 769
            |||||:|||||||||||||||||||||||||||||||||||||.||||||||||||||.:|||||
Mouse   683 LLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDSLVCLSHINDLCKCSRNRQYLR 747

Human   770 YRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEARERRFPNSELLQ 834
            |||||||||.||.||||||||||.|||||:.|||||||||||||||||||||||:||||||||||
Mouse   748 YRYTLDELPAMLQKLKIRAESFDNWANKVQAALEVEDGRKRSFEELRALESEARDRRFPNSELLQ 812

Human   835 RLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVE 899
            |||.||:|.||||:|||||:|....|:.|||:|||||::||:|||:|||.||||.:|||||:|||
Mouse   813 RLKKCLTEAEACISQVLGLISNSEDRLQTPQITLTELQLLLKQMGTLPCTMHQIDEVKDVLQQVE 877

Human   900 AYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGS 964
            :||.|.||||.:||.|..:|:||:|:||||.|||||||||::.:|||||||:||||||||..|.|
Mouse   878 SYQIETREALTSLPYSLEILQSLMEKGQQLRVEVPEAHQLEELLEQAQWLDQVKQALAPSGQRHS 942

Human   965 LVIMQGLLVMGAKIASSPSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETEN 1029
            ||||:.|||||.|:||||||:||||||||||||||.|||||||||:|.|||.|||||.||||.||
Mouse   943 LVIMKKLLVMGTKVASSPSVNKARAELQELLTIAECWEEKAHFCLKASQKHSPATLEVIIREAEN 1007

Human  1030 IPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVL 1094
            |||:|||||:|||||||||||||||:||||||||||||||||||||||||||.||||||||.|||
Mouse  1008 IPVYLPNIQSLKEALTKAQAWIADVNEIQNGDHYPCLDDLEGLVAVGRDLPVELEELRQLENQVL 1072

Human  1095 TAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLR 1159
            |||||:||||||||||||||||||||||||||||.|||||||:||.:|||:.|||||||||||||
Mouse  1073 TAHSWKEKASKTFLKKNSCYTLLEVLCPCADAGSVSTKRSRWIEKEMGLYKYDTELLGLSAQDLR 1137

Human  1160 DPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQ 1224
            ||||||:||||||:|||||||.||..|||||||::.|:.||: ||||:||||.|||..||||||.
Mouse  1138 DPGSVIMAFKEGEEKEKEGILHLRHINSAKPSPMSSSMNASA-TSICICGQVCAGVESLQCDLCH 1201

Human  1225 DWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVR 1289
            ||||||||:|||||:|.:.|.|||.||||||||||||||||||||||||||||:|||.||||.||
Mouse  1202 DWFHGQCVTVPHLLSSVRASHTSSQLLAWWEWDTKFLCPLCMRSRRPRLETILSLLVGLQRLSVR 1266

Human  1290 LPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATACDPI 1354
            ||||||||||||||||||.|||:|||||||||||:||.:.|||||.:.|.::.....|..|.|.:
Mouse  1267 LPEGEALQCLTERAIGWQGRARQALASEDVTALLKQLEKSRQQLQDELRHKKPPTLPSGFAFDCL 1331

Human  1355 REGSGNNISK-VQGLLENGDSVTSPENMAPGKGS---DLELLSSLLPQLTGPVLELPEAIRAPLE 1415
            .|.||.:|.| .:.|:.|.:.:.|.|.:.|.:.|   |.|||.|||.||||||||||||.|||||
Mouse  1332 TENSGKDILKEEEELVLNEERIKSSEKIVPKESSCKGDKELLPSLLSQLTGPVLELPEATRAPLE 1396

Human  1416 ELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALERRR-RRQKV 1479
            ||||||||||||||||:||||||||||.|:|:||.|||||||.|:.|:.:..:..|||| |||||
Mouse  1397 ELMMEGDLLEVTLDENYSIWQLLQAGQNPNLERIHTLLELEKPENPGNWSEEQTPERRRQRRQKV 1461

Human  1480 DQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDHSPFLKGNQNSLQH 1544
            ...|..|:..|:||:|||.:|    |::..:||.:|:....:|:..|..|:|:..||.:.||:|.
Mouse  1462 VLSRKGEDFTQKELESKRVKS----SRIKPKEEKFQKPILGDNVLYTHHTEHTNILKEHINSVQG 1522

Human  1545 KDSGSSAACPSLMPLLQLSYSDEQQL 1570
            ||...|::.|||.|||.|||..:|:|
Mouse  1523 KDPSPSSSFPSLTPLLHLSYFHQQKL 1548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM5D	NP_001140177.1	JmjN	13..54	CDD:128818	39/40 (98%)
		ARID_KDM5C_5D	79..170	CDD:350639	85/90 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	192..228		32/35 (91%)
		PHD1_KDM5C_5D	316..361	CDD:277077	33/44 (75%)
		JmjC	522..638	CDD:396791	113/115 (98%)
		zf-C5HC2	728..780	CDD:460750	48/51 (94%)
		PLU-1	793..1118	CDD:462475	262/324 (81%)
		PHD2_KDM5C_5D	1205..1265	CDD:277081	47/59 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1460..1552		35/92 (38%)
Kdm5d	NP_035549.1	JmjN	13..54	CDD:128818	39/40 (98%)
		ARID_KDM5C_5D	79..170	CDD:350639	85/90 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..229		17/20 (85%)
		PHD1_KDM5C_5D	325..370	CDD:277077	33/44 (75%)
		JmjC	500..616	CDD:396791	113/115 (98%)
		zf-C5HC2	706..758	CDD:460750	48/51 (94%)
		PLU-1	771..1096	CDD:462475	262/324 (81%)
		PHD_SF	1182..1242	CDD:473978	47/59 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1438..1468		13/29 (45%)